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Report error Found 417 of affinity data for UniProtKB/TrEMBL: Q05940
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459619(CHEMBL4206824)
Affinity DataKd:  71nMAssay Description:Binding affinity to human VMAT2 expressed in HEK293 cell membranes by scintillation counting method based saturation binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataKd:  8nMAssay Description:Binding affinity to human VMAT2 expressed in HEK293 cell membranes by scintillation counting method based saturation binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459629(CHEMBL4207838)
Affinity DataKd:  93nMAssay Description:Binding affinity to human VMAT2 expressed in HEK293 cell membranes by scintillation counting method based saturation binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataKd:  93nMAssay Description:Displacement of [3H](+)-syn-Ethyl 1-(2-(2,4-Dioxo-1,2-dihydroquinazolin-3(4H)-yl)ethyl)-4-(4-fluorophenyl)piperidine-3-carboxylate from human VMAT2 e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50: 16nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459625(CHEMBL4205254)
Affinity DataIC50: 16nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459630(CHEMBL4207658)
Affinity DataIC50: 20nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459619(CHEMBL4206824)
Affinity DataIC50: 28nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459621(CHEMBL4202787)
Affinity DataIC50: 39nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459626(CHEMBL4214975)
Affinity DataIC50: 86nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459628(CHEMBL4208250)
Affinity DataIC50: 101nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459627(CHEMBL4208779)
Affinity DataIC50: 125nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459617(CHEMBL4213176)
Affinity DataIC50: 142nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50192902(Ro-4-1284 | 2-ethyl-3-isobutyl-9,10-dimethoxy-2,3,...)
Affinity DataIC50: 154nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM291687(US9580437, Example 2 | N-((5-Fluoro-2,3-dihydroben...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of vesicular monoamine transporter 2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459618(CHEMBL4216117)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459624(CHEMBL4203894)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50009057(METHAMPHETAMINE (+) | Methyl-(1-methyl-2-phenyl-et...)
Affinity DataIC50: 3.62E+3nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50542723(CHEMBL4643449)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of VMAT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459620(CHEMBL4204449)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459623(CHEMBL4212633)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50459622(CHEMBL4217581)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to VMAT2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611939(US11718618, Compound 4-90 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  0.290nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611952(US11718618, Compound 4-119 | (2R,3R,11bR)-9- (cycl...)
Affinity DataKi:  0.290nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611867(US11718618, Compound 4-23 | 1-(2-{[(2R,3R,11bR)-3-...)
Affinity DataKi:  0.410nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611873(US11718618, Compound 4-28 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  0.480nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611905(US11718618, Compound 4-56 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  0.520nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611877(US11718618, Compound 4-32 | (2R,3R,11bR)-9-cyclobu...)
Affinity DataKi:  0.590nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611937(US11718618, Compound 4-88 | (2R,3R,11bR)-9- (cyclo...)
Affinity DataKi:  0.680nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611954(US11718618, Compound 4-121 | (2R,3R,11bR)-9-[(2,2-...)
Affinity DataKi:  0.820nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611906(US11718618, Compound 4-57 | (2R,3R,11bR)-9-{[1- (d...)
Affinity DataKi:  0.930nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611872(US11718618, Compound 4-27 | (2R,3R,11bR)-9-cyclopr...)
Affinity DataKi:  1nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611856(US11718618, Compound 4-15 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611858((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-ethoxy-10- ...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611900(US11718618, Compound 4-55 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611858((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-ethoxy-10- ...)
Affinity DataKi:  1.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611895(US11718618, Compound 4-50 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611908(US11718618, Compound 4-59 | 5-({[(2R,3R,11bR)-3-(2...)
Affinity DataKi:  1.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611953(US11718618, Compound 4-120 | (2R,3R,11bR)-3-(2,2- ...)
Affinity DataKi:  1.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611876(US11718618, Compound 4-31 | (2R,3R,11bR)-3-(2,2- d...)
Affinity DataKi:  1.60nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611854(US11718618, Compound 4-13 | (2R,3R,11bR)-9-(2,2- d...)
Affinity DataKi:  2.20nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611950(US11718618, Compound 4-117 | (2R,3R,11bR)-3-(2,2- ...)
Affinity DataKi:  2.20nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611842(US11718618, Compound 4-1 | (2R,3R,11bR)-3-(2,2- di...)
Affinity DataKi:  2.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611889(US11718618, Compound 4-44 | 2-(2-{[(2R,3R,11bR)-3-...)
Affinity DataKi:  2.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSynaptic vesicular amine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM611897((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-(methoxy- d...)
Affinity DataKi:  2.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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