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Report error Found 799 of affinity data for UniProtKB/TrEMBL: Q04609
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50046829(CHEMBL3309679)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to human recombinant N-terminal Avi-tagged glutamate carboxypeptidase 2 extracellular domain (44 to 750 amino acids) using biotin-ta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265765(5-[((S)-3-{3-[5-tert-Butoxycarbonylamino-3,7-bis-(...)
Affinity DataKd:  0.800nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in phosphate-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265769(Boc-AdamGPI Trimer | CHEMBL507394)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in presence of 100% calf serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265768(2-({[(3S)-3-{3-[3-(6-{[(tert-butoxy)carbonyl]amino...)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in presence of 100% calf serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265765(5-[((S)-3-{3-[5-tert-Butoxycarbonylamino-3,7-bis-(...)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to PSMA in human PC3 cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265765(5-[((S)-3-{3-[5-tert-Butoxycarbonylamino-3,7-bis-(...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to PSMA in human PC3 cells assessed as cell surface binding in phosphate-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265765(5-[((S)-3-{3-[5-tert-Butoxycarbonylamino-3,7-bis-(...)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to PSMA in human PC3 cells assessed as cell surface binding in presence of 100% calf serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265763(2-((((S)-3-amino-3-carboxypropyl)(hydroxy)phosphor...)
Affinity DataKd:  10.5nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265769(Boc-AdamGPI Trimer | CHEMBL507394)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265768(2-({[(3S)-3-{3-[3-(6-{[(tert-butoxy)carbonyl]amino...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265767(2-[((S)-3-{3-[5-(6-tert-Butoxycarbonylamino-hexano...)
Affinity DataKd:  16.4nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265765(5-[((S)-3-{3-[5-tert-Butoxycarbonylamino-3,7-bis-(...)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265769(Boc-AdamGPI Trimer | CHEMBL507394)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in phosphate-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265768(2-({[(3S)-3-{3-[3-(6-{[(tert-butoxy)carbonyl]amino...)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in phosphate-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to PSMA in human PC3 cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50265377(CHEMBL496748 | CHEMBL2431335 | (S)-2-(3-((S)-1-Car...)
Affinity DataKd:  20nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50441243(CHEMBL2431334)
Affinity DataKd:  143nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50441241(CHEMBL2431333 | CHEMBL2431336)
Affinity DataKd:  7.80nMAssay Description:Binding affinity to PSMA in human LNCaP cells after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412695(CHEMBL2079731)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in phosphate-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412696(CHEMBL2021414)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in presence of 100% calf serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412695(CHEMBL2079731)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in presence of 100% calf serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412697(CHEMBL2079727)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412696(CHEMBL2021414)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412698(CHEMBL2079722)
Affinity DataKd:  5.40nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412695(CHEMBL2079731)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412699(CHEMBL2079726)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in Tris-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412697(CHEMBL2079727)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in phosphate-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50412696(CHEMBL2021414)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in phosphate-buffered saline bufferMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50129199(2-(3-Hydroxycarbamoyl-propyl)-pentanedioic acid | ...)
Affinity DataEC50:  1.10E+3nMAssay Description:Concentration required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM17779(2-[(hydroxycarbamoyl)methyl]pentanedioic acid | CH...)
Affinity DataEC50:  220nMAssay Description:Concentration required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataEC50:  0.620nMAssay Description:Concentration required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM17755(pentanedioic acid analogue, (RS)-3 | CHEMBL303352 ...)
Affinity DataEC50:  13nMAssay Description:Concentration required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM17752(CHEMBL64901 | 2-({hydroxy[(2,3,4,5,6-pentafluoroph...)
Affinity DataEC50:  9.5nMAssay Description:Concentration required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703001(US20240366813, Compound E2)
Affinity DataKd:  0.229nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703002(US20240366813, Compound E3)
Affinity DataKd:  0.550nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703003(US20240366813, Compound E4)
Affinity DataKd:  0.269nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703004(US20240366813, Compound E8)
Affinity DataKd:  0.324nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703005(US20240366813, Compound E9)
Affinity DataKd:  0.282nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703006(US20240366813, Compound E13)
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703007(US20240366813, Compound E18)
Affinity DataKd:  0.00100nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703008(US20240366813, Compound E20)
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703009(US20240366813, Compound E21)
Affinity DataKd:  0.151nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703010(US20240366813, Compound E22)
Affinity DataKd:  0.100nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703011(US20240366813, Compound E24)
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703012(US20240366813, Compound E25)
Affinity DataKd:  0.0710nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM703013(US20240366813, Compound E26)
Affinity DataKd:  0.363nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGUS20240366813, Compound PSMA-617(Vipivotide tetraxetan | PSMA-617)
Affinity DataKd:  0.00200nMMore data for this Ligand-Target Pair
In DepthDetails

TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50246899(N-{[(1S)-1-carboxy-5-{[(4-iodophenyl)carbonyl]amin...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50468173(CHEMBL4284995)
Affinity DataIC50: 0.0750nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
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