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Report error Found 5080 of affinity data for UniProtKB/TrEMBL: Q01959
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  498nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299788(4-(2-(3-fluorophenoxy)phenyl)piperidine | CHEMBL58...)
Affinity DataEC50:  657nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299792(4-(3-fluoro-2-phenoxyphenyl)piperidine | CHEMBL583...)
Affinity DataEC50:  982nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299798(4-(2-(3-chlorophenoxy)phenyl)piperidine | CHEMBL57...)
Affinity DataEC50:  1.88E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299797(1-(2-(benzyloxy)phenyl)piperazine | CHEMBL582928)
Affinity DataEC50:  5.21E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  498nMAssay Description:Agonist activity at DATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309519(2-(2-chloro-6-fluorophenoxy)-3-(piperidin-4-yl)pyr...)
Affinity DataEC50:  6.88E+3nMAssay Description:Agonist activity at DATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50022723((2S)-1-phenylpropan-2-amine | (S)-amphetamine | (+...)
Affinity DataEC50:  24.8nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT cloned in rat brain synaptosome by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKd:  9.30E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069447(2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-e...)
Affinity DataKd:  360nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069446((1S,2R)-1-Cyclohexyl-3-dimethylamino-2-(4-methoxy-...)
Affinity DataKd:  3.50E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069452((1R,2R)-3-Dimethylamino-2-phenyl-1-(2,4,6-trimethy...)
Affinity DataKd:  4.20E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataKd:  25nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069449((2R,3R)-1-Dimethylamino-4,4-dimethyl-2-naphthalen-...)
Affinity DataKd:  340nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069453((1R,2R)-3-Dimethylamino-2-naphthalen-2-yl-1-phenyl...)
Affinity DataKd:  70nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069450((2R,3R)-1-Dimethylamino-4,4-dimethyl-2-phenyl-pent...)
Affinity DataKd:  2.14E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069445((1R,2R)-3-Dimethylamino-1,2-diphenyl-propan-1-ol; ...)
Affinity DataKd:  1.20E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter -hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50366567(ATOMOXETINE)
Affinity DataKd:  1.08E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50025691(2-(2-Ethoxy-phenoxymethyl)-morpholine(viloxazine) ...)
Affinity DataKd:  155nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069451((2R,3R)-1-Amino-4,4-dimethyl-2-phenyl-pentan-3-ol;...)
Affinity DataKd:  7.26E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataKd:  3.60E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069442((2R,3R)-1-Amino-4,4-dimethyl-2-naphthalen-2-yl-pen...)
Affinity DataKd:  2.70E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069443((1R,2R)-3-Amino-1,2-diphenyl-propan-1-ol; hydrochl...)
Affinity DataKd:  2.40E+4nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069444((1R,2R)-3-Amino-2-phenyl-1-(2,4,6-trimethyl-phenyl...)
Affinity DataKd:  340nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069454((1S,2R)-3-Amino-1-cyclohexyl-2-(4-methoxy-phenyl)-...)
Affinity DataKd:  4.31E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069448((1R,2R)-3-Amino-2-naphthalen-2-yl-1-phenyl-propan-...)
Affinity DataKd:  140nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataKd:  490nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287933(N-(2-(6-chloropyridin-2-yl)-2- phenylethyl)-2-(p-t...)
Affinity DataEC50:  380nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287934(N-(4-(4-((2-phenyl-2-(pyridin-2- yl)ethyl)amino)qu...)
Affinity DataEC50:  50nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287935(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyridi...)
Affinity DataEC50:  22nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287936(N-(4-(4-((2-hydroxy-2,2- diphenylethyl)amino)quina...)
Affinity DataEC50:  11nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287937(2-((2-(4- (dimethylamino)phenyl)quinazolin-4- yl)a...)
Affinity DataEC50:  6.70nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287938(N-(4-(4-((2-cyclohexyl-2- phenylethyl)amino)quinaz...)
Affinity DataEC50:  16nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287939(N-(2-cyclohexyl-2-phenylethyl)-2-(4- (dimethylamin...)
Affinity DataEC50:  46nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287940(N-(4-(4-((2-phenyl-2-(pyrimidin-2- yl)ethyl)amino)...)
Affinity DataEC50:  477nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287941(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyrimi...)
Affinity DataEC50:  117nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287942(N-(4-(4-((2-phenyl-2-(pyridin-4- yl)ethyl)amino)qu...)
Affinity DataEC50:  4.80nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287943(2-(4-dimethylamino)phenyl)-N-(2- phenyl-2-(pyridin...)
Affinity DataEC50:  13nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287944(N-(4-(4-((2-(1H-imidazol-1-yl)-2- phenylethyl)amin...)
Affinity DataEC50:  100nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287945(N-(2-(1H-imidazol-1-yl)-2- phenylethyl)-2-(4- (dim...)
Affinity DataEC50:  138nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287946(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(1H-pyr...)
Affinity DataEC50:  5.60nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287947(N-(4-(4-((2-phenyl-2-(1H-pyrrol-2- yl)ethyl)amino)...)
Affinity DataEC50:  43nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287948(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(piperi...)
Affinity DataEC50:  34nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287949(N-(4-(4-((2-phenyl-2-(piperidin-1- yl)ethyl)amino)...)
Affinity DataEC50:  62nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287950(2-(4-(dimethylamino)phenyl)-N-(2- morpholino-2-phe...)
Affinity DataEC50:  15nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287951(N-(4-(4-((2-morpholino-2- phenylethyl)amino)quinaz...)
Affinity DataEC50:  43nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287952(N-(4-(4-((2-phenyl-2-(pyrrolidin-1- yl)ethyl)amino...)
Affinity DataEC50:  160nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287953(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyrrol...)
Affinity DataEC50:  112nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287954(2-(4-(dimethylamino)phenyl)-N-(2-(4- methylpiperaz...)
Affinity DataEC50:  30nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM287955(N-(4-(4-((2-(4-methylpiperazin-1-yl)-2- phenylethy...)
Affinity DataEC50:  62nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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