Compile Data Set for Download or QSAR
Report error Found 559 for UniProtKB: P62813
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273004(5-Piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione Hydr...)
Affinity DataEC50:  9.50E+6nMAssay Description:Agonist activity at rat wild type GABAA alpha-1-beta-2 receptor expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at rat wild type GABAA alpha-1-beta-2 receptor expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  2.80E+5nMAssay Description:Agonist activity at rat recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50459891(CHEMBL4229086)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at GABAA receptor in Sprague-Dawley rat forebrain membranes assessed as enhancement of [3H]muscimol binding after 2 hrs by radiometr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of C57BL/6 mouse GABAA receptor alpha1beta3gamma2 assessed as increase in GABA-induced current response at -60 mV hold...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataEC50:  2.01E+3nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha1beta3gamma2 expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/delta(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457445(CHEMBL4212818)
Affinity DataEC50:  860nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha1beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataEC50:  100nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha1beta3 expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/delta(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataEC50:  100nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha1beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50427613(CHEMBL2322935)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462443(CHEMBL4238315)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462444(CHEMBL4244129)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462446(CHEMBL4238634)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462450(CHEMBL4238712)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482687(CHEMBL426916)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540735(US11261211, Compound SA-2)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540736(US11261211, Compound SA-4)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540748(US11261211, Compound SA-11)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540753(US11261211, Compound SA-14)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540754(US11261211, Compound SA-15)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540759(US11261211, Compound SA-39)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540762(US11261211, Compound SA-55)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540766(US11261211, Compound SA-57)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540767(US11261211, Compound SA-58)
Affinity DataIC50: 10nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM705319(US20240376144, Example 1)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM705320(US20240376144, Example 2)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM705321(US20240376144, Example 4)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM705322(US20240376144, Example 5)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM705323(US20240376144, Example 6)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM705324(US20240376144, Example 7)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM705325(US20240376144, Example 8.2b)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM23183(CHEMBL273481 | Muscimol | 5-(aminomethyl)-1,2-oxaz...)
Affinity DataIC50: 16nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM520647(US11147877, Compound 2)
Affinity DataIC50: 20nMAssay Description:Briefly, cortices are rapidly removed following decapitation of carbon dioxide-anesthetized Sprague-Dawley rats (200-250 g). The cortices are homogen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482692(CHEMBL390326)
Affinity DataIC50: 20nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238234(US9388210, 14a | US9388210, 6a)
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238243(US9388210, 16a)
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482688(CHEMBL387958)
Affinity DataIC50: 30nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482694(CHEMBL229535)
Affinity DataIC50: 30nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540734(US11261211, Compound SA-1)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540737(US11261211, Compound SA-3)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540738(US11261211, Compound SA-7)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540739(US11261211, Compound SA-8)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540740(US11261211, Compound SA-6)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540741(US11261211, Compound SA-5)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540742(US11261211, Compound SA-16)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540743(US11261211, Compound SA-17)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540744(US11261211, Compound SA-18)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM540745(US11261211, Compound SA-19)
Affinity DataIC50: 30nMAssay Description:TBPS binding assays using rat brain cortical membranes in the presence of 5 μM GABA has been described (Gee et al, J. Pharmacol. Exp. Ther. 1987...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Displayed 1 to 50 (of 559 total ) | Next | Last >>
Jump to: