Compile Data Set for Download or QSAR
Report error Found 79 for UniProtKB: P62805
TargetHistone H4(Human)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397030(CHEMBL2171189)
Affinity DataKd:  2.38E+4nMAssay Description:Binding affinity to fluorescein-labeled Histone H4(1-20) by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209487(US9266891, III-28 | US10328074, Example III-28 | U...)
Affinity DataIC50: 1nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209474(US9266891, III-15 | US10328074, Example III-15 | U...)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209482(US9266891, III-23 | US10328074, Example III-23 | U...)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209481(US9266891, III-22 | US10328074, Example III-22 | U...)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209457(US9266891, II-1 | US10328074, Example II-1 | US110...)
Affinity DataIC50: 4nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209508(US9266891, III-49 | US10328074, Example III-49 | U...)
Affinity DataIC50: 4nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209475(US9266891, III-16 | US10328074, Example III-16 | U...)
Affinity DataIC50: 5nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209509(US9266891, III-50 | US10328074, Example III-50 | U...)
Affinity DataIC50: 5nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209485(US9266891, III-26 | US10328074, Example III-26 | U...)
Affinity DataIC50: 5nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209460(US9266891, III-1 | US10328074, Example III-1 | US1...)
Affinity DataIC50: 7nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209471(US9266891, III-12 | US10328074, Example III-12 | U...)
Affinity DataIC50: 7nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209491(US9266891, III-32 | US10328074, Example III-32 | U...)
Affinity DataIC50: 7nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209480(US9266891, III-21 | US10328074, Example III-21 | U...)
Affinity DataIC50: 8nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209507(US9266891, III-48 | US10328074, Example III-48 | U...)
Affinity DataIC50: 8nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209453(US9266891, I-5 | US10328074, Example I-5 | US11077...)
Affinity DataIC50: 8nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209463(US9266891, III-4 | US10328074, Example III-4 | US1...)
Affinity DataIC50: 8nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209465(US9266891, III-6 | US10328074, Example III-6 | US1...)
Affinity DataIC50: 9nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209488(US9266891, III-29 | US10328074, Example III-29 | U...)
Affinity DataIC50: 9nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209489(US9266891, III-30 | US10328074, Example III-30 | U...)
Affinity DataIC50: 9nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209464(US9266891, III-5 | US10328074, Example III-5 | US1...)
Affinity DataIC50: 9nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209467(US9266891, III-8 | US10328074, Example III-8 | US1...)
Affinity DataIC50: 9nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209470(US9266891, III-11 | US10328074, Example III-11 | U...)
Affinity DataIC50: 9nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209472(US9266891, III-13 | US10328074, Example III-13 | U...)
Affinity DataIC50: 9nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209473(US9266891, III-14 | US10328074, Example III-14 | U...)
Affinity DataIC50: 10nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209486(US9266891, III-27 | US10328074, Example III-27 | U...)
Affinity DataIC50: 10nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209484(US9266891, III-25 | US10328074, Example III-25 | U...)
Affinity DataIC50: 11nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209506(US9266891, III-47 | US11077107, Example III-47)
Affinity DataIC50: 12nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209512(US9266891, III-53 | US10328074, Example III-53 | U...)
Affinity DataIC50: 12nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4/Histone H4(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM179292(US9125915, compound 17)
Affinity DataIC50: 12.8nMT: 2°CAssay Description:An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209479(US9266891, III-20 | US10328074, Example III-20 | U...)
Affinity DataIC50: 13nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209490(US9266891, III-31 | US10328074, Example III-31 | U...)
Affinity DataIC50: 13nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209510(US9266891, III-51 | US10328074, Example III-51 | U...)
Affinity DataIC50: 13nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209468(US9266891, III-9 | US10328074, Example III-9 | US1...)
Affinity DataIC50: 14nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209496(US9266891, III-37 | US10328074, Example III-37 | U...)
Affinity DataIC50: 14nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209458(US9266891, II-2 | US10328074, Example II-2 | US110...)
Affinity DataIC50: 15nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209494(US9266891, III-35 | US10328074, Example III-35 | U...)
Affinity DataIC50: 15nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209476(US9266891, III-17 | US10328074, Example III-17 | U...)
Affinity DataIC50: 17nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209497(US9266891, III-38 | US10328074, Example III-38 | U...)
Affinity DataIC50: 17nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4/Histone H4(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM179288(US9125915, compound 13)
Affinity DataIC50: 17.3nMT: 2°CAssay Description:An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209469(US9266891, III-10 | US10328074, Example III-10 | U...)
Affinity DataIC50: 18nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209499(US9266891, III-40 | US10328074, Example III-40 | U...)
Affinity DataIC50: 18nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209452(US9266891, I-4 | US10328074, Example I-4)
Affinity DataIC50: 18nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4/Histone H4(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM179283(US9125915, compound 6)
Affinity DataIC50: 18.2nMT: 2°CAssay Description:An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209492(US9266891, III-33 | US10328074, Example III-33 | U...)
Affinity DataIC50: 20nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209483(US9266891, III-24 | US10328074, Example III-24 | U...)
Affinity DataIC50: 20nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4/Histone H4(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM179289(US9125915, compound 14)
Affinity DataIC50: 21nMT: 2°CAssay Description:An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209466(US9266891, III-7 | US10328074, Example III-7 | US1...)
Affinity DataIC50: 22nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209477(US9266891, III-18 | US10328074, Example III-18 | U...)
Affinity DataIC50: 26nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209495(US9266891, III-36 | US10328074, Example III-36 | U...)
Affinity DataIC50: 28nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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