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TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  60nMAssay Description:Average Binding Constant for RPS6KA3 (Kin.Dom. 1); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  69nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  740nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  65nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  290nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  69nMAssay Description:Binding constant for RPS6KA3(Kin.Dom.1 - N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  740nMAssay Description:Binding constant for RPS6KA3(Kin.Dom.1 - N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  55nMAssay Description:Average Binding Constant for RPS6KA3 (Kin.Dom. 1); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  2.20E+3nMAssay Description:Average Binding Constant for RPS6KA3 (Kin.Dom. 1); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50248765(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)
Affinity DataEC50:  150nMAssay Description:Inhibition of PMA-stimulated RSK2 phosphorylation in HEK293 cells after 1 hr by Western blotting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50324684(3-(1-(4-amino-6-(2-fluoroacetyl)-5-p-tolyl-7H-pyrr...)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of PMA-stimulated RSK2 phosphorylation in HEK293 cells after 1 hr by Western blotting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50314070(pamapimod | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-...)
Affinity DataKd:  300nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50341342(6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-...)
Affinity DataKd:  150nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355495(CHEMBL1908391)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  280nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM15138(Biochemistry 469551 Compound 11 | 5-indazolyl pyri...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542)
Affinity DataKd:  8.00E+3nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM27817(2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...)
Affinity DataKd:  170nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKd:  3.00E+3nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataKd:  87nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  3.60E+3nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355494(CHEMBL1908396)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50309910(N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  17nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM60589(6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM24654(pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  2.10E+3nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM15244(cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM26300(cid_16007391 | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)a...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  200nMAssay Description:Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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