Compile Data Set for Download or QSAR
Report error Found 18 of affinity data for UniProtKB/TrEMBL: P50578
LigandPNGBDBM50009832(CHEMBL269550 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydr...)
Affinity DataIC50: 0.480nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50009844(CHEMBL7480 | 2-fluorospiro[9H-fluorene-9,4'-(tetra...)
Affinity DataIC50: 27nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 40nMAssay Description:Inhibition of pig ALR1More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 540nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesMore data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory activity measured against pig kidney aldehyde reductase using 3-pyridinecarboxaldehyde as substrateMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50009777(Ponalrestat (statil) | CHEMBL7679 | [3-(4-Bromo-2-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of pig ALR1More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16512((2S,4S)-6-fluoro-2,5-dioxo-2,3-dihydrospiro[chrome...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50009832(CHEMBL269550 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydr...)
Affinity DataIC50: 3.65E+3nMAssay Description:Inhibitory activity was measured against pig kidney aldehyde reductase in the presence of 1 uM compound with 3-pyridine carboxaldehyde as substratesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16312(CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-be...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50213307([(5Z)-5-{[3-(carboxymethoxy)-4-methoxyphenyl]methy...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of pig ALR1 assessed as decrease in NADPH absorbance by spectrophotometryMore data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | CHEMBL449129 ...)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of pig ALR1More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50089423(6-fluoro-2',5'-dioxo-(2R,4'S)-spiro[3,4-dihydro-2H...)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehydeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50312535([5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxothiaz...)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of pig ALR1 assessed as decrease in NADPH absorbance by spectrophotometryMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 3.84E+4nMAssay Description:Inhibition of pig ALR1More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50009834(sodium valproate | CHEMBL433 | Epilim | sodium 2-p...)
Affinity DataIC50: 8.90E+4nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009839(2-Methyl-1,4-dioxo-1,2,3,4-tetrahydro-naphthalene-...)
Affinity DataIC50: 4.90E+5nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed