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TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659822(N-Cyclopropyl-7-hydroxy-4-isobutyl-5-oxo-3-((pyrid...)
Affinity DataIC50: 0.180nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659957(N-Cyclopropyl-4-hydroxy-1-neopentyl-2,8-dioxo-1,2,...)
Affinity DataIC50: 0.390nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660316(3-((E)-3-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-...)
Affinity DataIC50: 0.480nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659933((R,E)-N-Cyclopropyl-7-hydroxy-4-((1-methylcyclopro...)
Affinity DataIC50: 0.540nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659935((R,E)-N-Cyclopropyl-7-hydroxy-3-(3-(3-(methoxymeth...)
Affinity DataIC50: 0.550nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660095((R,E)-N-Cyclopropyl-7-hydroxy-4-isobutyl-3-(3-(3-(...)
Affinity DataIC50: 0.550nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659964(N-Cyclopropyl-9-hydroxy-6-neopentyl-2,7-dioxo-1,2,...)
Affinity DataIC50: 0.560nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660080((E)-N-Cyclopropyl-7-hydroxy-4-isobutyl-3-(3-((2-me...)
Affinity DataIC50: 0.570nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659932((S,E)-N-Cyclopropyl-7-hydroxy-4-((1-methylcyclopro...)
Affinity DataIC50: 0.580nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660019((E)-3-(3-(8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)-3-o...)
Affinity DataIC50: 0.580nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660077((E)-N-Cyclopropyl-3-(3-(1,1-dioxidothiomorpholino)...)
Affinity DataIC50: 0.580nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659979((E)-2-Amino-N-cyclopropyl-7-hydroxy-4-isobutyl-3-(...)
Affinity DataIC50: 0.590nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659980((S,E)-2-Amino-N-cyclopropyl-7-hydroxy-4-isobutyl-3...)
Affinity DataIC50: 0.590nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660060((E)-N-Cyclopropyl-3-(3-(cyclopropyl(methyl)amino)-...)
Affinity DataIC50: 0.590nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660084((S,E)-N-Cyclopropyl-7-hydroxy-3-(3-(2-(hydroxymeth...)
Affinity DataIC50: 0.590nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659949((E)-N-Cyclopropyl-7-hydroxy-4-((4-methyltetrahydro...)
Affinity DataIC50: 0.600nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660013((E)-N6-Cyclopropyl-7-hydroxy-4-isobutyl-3-(3-morph...)
Affinity DataIC50: 0.600nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659931((E)-3-(3-(8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)-3-o...)
Affinity DataIC50: 0.610nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659934((S,E)-N-Cyclopropyl-7-hydroxy-3-(3-(3-(methoxymeth...)
Affinity DataIC50: 0.610nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659966(N-Cyclopropyl-4-hydroxy-1-neopentyl-2,8-dioxo-1,2,...)
Affinity DataIC50: 0.610nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659981((R,E)-2-Amino-N-cyclopropyl-7-hydroxy-4-isobutyl-3...)
Affinity DataIC50: 0.610nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660079((E)-N-Cyclopropyl-7-hydroxy-4-isobutyl-5-oxo-3-(3-...)
Affinity DataIC50: 0.610nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660318(N-Cyclopropyl-3-((E)-3-(trans-3,4-difluoropyrrolid...)
Affinity DataIC50: 0.610nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659930((E)-3-(3-(3-Oxa-8-azabicyclo[3.2.1]octan-8-yl)-3-o...)
Affinity DataIC50: 0.620nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660119(N-Cyclopropyl-3-((E)-3-((3R,5R)-3,5-dimethylmorpho...)
Affinity DataIC50: 0.620nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659927((E)-N-Cyclopropyl-4-((1-fluorocyclopropyl)methyl)-...)
Affinity DataIC50: 0.630nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659965(N-Cyclopropyl-7-hydroxy-4-neopentyl-2,5-dioxo-2,3,...)
Affinity DataIC50: 0.630nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659967(N-Cyclopropyl-4-hydroxy-1-isobutyl-2,8-dioxo-1,2,7...)
Affinity DataIC50: 0.630nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660145((E)-N-Cyclopropyl-7-hydroxy-2-methyl-3-(3-morpholi...)
Affinity DataIC50: 0.630nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659784(N6-Cyclopropyl-7-hydroxy-4-isobutyl-5-oxo-N3-((tet...)
Affinity DataIC50: 0.640nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660040((E)-3-(3-(4-Carbamoylpiperidin-1-yl)-3-oxoprop-1-e...)
Affinity DataIC50: 0.640nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660096((E)-3-(3-(3-Oxa-8-azabicyclo[3.2.1]octan-8-yl)-3-o...)
Affinity DataIC50: 0.640nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660102(3-((E)-3-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-...)
Affinity DataIC50: 0.640nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660244((E)-3-(3-((Cyanomethyl)(methyl)amino)-3-oxoprop-1-...)
Affinity DataIC50: 0.640nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659771(N6-Cyclopropyl-7-hydroxy-4-neopentyl-5-oxo-4,5-dih...)
Affinity DataIC50: 0.650nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659790(N-Cyclopropyl-7-hydroxy-4-isobutyl-3-(morpholine-4...)
Affinity DataIC50: 0.650nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659794(N6-Cyclopropyl-7-hydroxy-4-isobutyl-5-oxo-N3-(pyri...)
Affinity DataIC50: 0.650nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659928((E)-N-Cyclopropyl-7-hydroxy-4-(2-methoxy-2-methylp...)
Affinity DataIC50: 0.650nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659937(3-((E)-3-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-...)
Affinity DataIC50: 0.650nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659938(3-((E)-3-((1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-...)
Affinity DataIC50: 0.650nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659974((E)-2-Amino-N-cyclopropyl-7-hydroxy-3-(3-morpholin...)
Affinity DataIC50: 0.650nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660006((E)-2-Amino-N-cyclopropyl-7-hydroxy-5-oxo-4-((tetr...)
Affinity DataIC50: 0.650nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660088((S,E)-N-Cyclopropyl-7-hydroxy-3-(3-(3-(hydroxymeth...)
Affinity DataIC50: 0.650nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659995(N-Cyclopropyl-3-((E)-3-((3S,5S)-3,5-dimethylmorpho...)
Affinity DataIC50: 0.660nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660008((E)-2-Amino-N-cyclopropyl-7-hydroxy-4-((4-methylte...)
Affinity DataIC50: 0.660nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660081((E)-N-Cyclopropyl-7-hydroxy-3-(3-((2-hydroxy-2-met...)
Affinity DataIC50: 0.660nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660103((R,E)-N-Cyclopropyl-3-(3-(3-ethylmorpholino)-3-oxo...)
Affinity DataIC50: 0.660nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660108((S,E)-7-Hydroxy-4-isobutyl-3-(3-morpholino-3-oxopr...)
Affinity DataIC50: 0.660nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM660194((E)-N-Cyclopropyl-7-hydroxy-4-isobutyl-2-methyl-5-...)
Affinity DataIC50: 0.660nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSepiapterin reductase(Human)
Nissan Chemical

US Patent
LigandPNGBDBM659987((E)-N-Cyclopropyl-7-hydroxy-3-(3-morpholino-3-oxop...)
Affinity DataIC50: 0.670nMAssay Description:Human SPR inhibitory activity was measured by using a 384-well low adsorption clear plate (Greiner) with buffer D containing 100 mM Tris-HCl (pH 7.5)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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