Affinity DataKd: 1.30nM EC50: 27nMAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
Affinity DataKd: 0.25nMAssay Description:The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredMore data for this Ligand-Target Pair
Affinity DataKd: 8.10nMAssay Description:The equilibrium binding constant to pig cerebral cortex membranes was measuredMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeMore data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeMore data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeMore data for this Ligand-Target Pair
Affinity DataEC50: 265nMAssay Description:In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeMore data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 0.700nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 6.90nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 1.30nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 0.990nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 3.70nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 0.640nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 0.100nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 2.5nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 71nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 0.320nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 3.70nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 140nMAssay Description:Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissueMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 977nMAssay Description:Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human CCK2R T2.61N mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human CCK2R V3.28T, S3.29T mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 282nMAssay Description:Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 59nMAssay Description:Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 119nMAssay Description:Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRMore data for this Ligand-Target Pair
Affinity DataEC50: 2.66nMAssay Description:Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRMore data for this Ligand-Target Pair
Affinity DataEC50: 572nMAssay Description:Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRMore data for this Ligand-Target Pair
Affinity DataKd: 0.110nMAssay Description:The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredMore data for this Ligand-Target Pair
Affinity DataKd: 3.20nMAssay Description:Tested in vitro for gastrin binding to gastrin receptors from guinea pig gastric glandsMore data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsMore data for this Ligand-Target Pair
Affinity DataEC50: 517nMAssay Description:Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 2.37E+3nMAssay Description:Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 98nMAssay Description:Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0930nMAssay Description:Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 5.60E+3nMAssay Description:Concentration of compound that induced 50% of the maximal contraction in guinea pig gallbladder tissue when tested in vitroMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Human)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 1.60E+3nMAssay Description:Concentration of compound that induced 50% of the maximal contraction in guinea pig gallbladder tissue when tested in vitroMore data for this Ligand-Target Pair
