Compile Data Set for Download or QSAR
Report error Found 7538 of affinity data for UniProtKB/TrEMBL: P31645
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM22166(RTI 55, (exo,exo)-isomer, Iodine (125) labeled | R...)
Affinity DataKd:  2.82nMAssay Description:Displacement of [125I]beta-CIT from human SERT in human platelet membrane in presence of 5 uM ibogaineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM22166(RTI 55, (exo,exo)-isomer, Iodine (125) labeled | R...)
Affinity DataKd:  0.880nMAssay Description:Displacement of [125I]beta-CIT from human SERT in human platelet plasma membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50299783(4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  915nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50299788(4-(2-(3-fluorophenoxy)phenyl)piperidine | CHEMBL58...)
Affinity DataEC50:  1.02E+3nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50299798(4-(2-(3-chlorophenoxy)phenyl)piperidine | CHEMBL57...)
Affinity DataEC50:  186nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50299792(4-(3-fluoro-2-phenoxyphenyl)piperidine | CHEMBL583...)
Affinity DataEC50:  1.76E+3nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50299797(1-(2-(benzyloxy)phenyl)piperazine | CHEMBL582928)
Affinity DataEC50:  2.93E+3nMAssay Description:Inhibition of [3H]5-HT uptake at human 5HTT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataEC50:  915nMAssay Description:Agonist activity at SERTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50309519(2-(2-chloro-6-fluorophenoxy)-3-(piperidin-4-yl)pyr...)
Affinity DataEC50:  409nMAssay Description:Agonist activity at SERTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50310868(2-N-Methylamino-1-(4-ethylthiophenyl)butane | CHEM...)
Affinity DataEC50: >1.00E+5nMAssay Description:Induction of human SERT-dependent cytotoxicity in SERT expressing HEK293 cells after 48 hrs by neutral red assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50459929(CHEMBL4228171)
Affinity DataKd:  210nMAssay Description:Binding affinity to human SERT expressed in HEK293 cells after 60 mins in presence of [3H]imipramine by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50476261(CHEMBL224093 | 4-(1-Methylpyridinium)Phenylmethane...)
Affinity DataEC50:  3.16E+4nMAssay Description:Decrease in [3H]5-HT uptake at human SERT W103C mutant transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50476262(CHEMBL224476)
Affinity DataEC50:  3.16E+3nMAssay Description:Decrease in [3H]5-HT uptake at human SERT G498C mutant transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50476262(CHEMBL224476)
Affinity DataEC50:  2.00E+5nMAssay Description:Decrease in [3H]5-HT uptake at human SERT W103C mutant transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50476261(CHEMBL224093 | 4-(1-Methylpyridinium)Phenylmethane...)
Affinity DataEC50:  3.98E+3nMAssay Description:Decrease in [3H]5-HT uptake at human SERT G498C mutant transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474028(CHEMBL41974)
Affinity DataKd:  759nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474030(CHEMBL40396)
Affinity DataKd:  257nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474040(CHEMBL42150)
Affinity DataKd:  1.20E+3nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474025(CHEMBL38468)
Affinity DataKd:  282nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474045(CHEMBL40529)
Affinity DataKd:  661nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474034(CHEMBL440110)
Affinity DataKd:  59nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474046(CHEMBL41027)
Affinity DataKd:  204nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474048(CHEMBL40240)
Affinity DataKd:  525nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474049(CHEMBL40961)
Affinity DataKd:  2.29E+3nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474029(CHEMBL288823)
Affinity DataKd:  468nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474056(CHEMBL41797)
Affinity DataKd:  813nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474059(CHEMBL39282)
Affinity DataKd:  214nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474062(CHEMBL416433)
Affinity DataKd:  229nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474050(CHEMBL289860)
Affinity DataKd:  132nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474064(CHEMBL41237)
Affinity DataKd:  229nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474036(CHEMBL416800)
Affinity DataKd:  813nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474066(CHEMBL41222)
Affinity DataKd:  676nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474058(CHEMBL43524)
Affinity DataKd:  282nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM22199(CHEMBL286991 | GBR-13,069 | CHEMBL112280 | 1-{2-[b...)
Affinity DataKd:  954nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474067(CHEMBL38942)
Affinity DataKd:  331nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474044(CHEMBL39890)
Affinity DataKd:  200nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474041(CHEMBL288914)
Affinity DataKd:  1.82E+3nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474057(CHEMBL41796)
Affinity DataKd:  191nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM22199(CHEMBL286991 | GBR-13,069 | CHEMBL112280 | 1-{2-[b...)
Affinity DataKd:  363nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474047(CHEMBL290536)
Affinity DataKd:  234nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474063(CHEMBL41390)
Affinity DataKd:  741nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474061(CHEMBL41061)
Affinity DataKd:  603nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474042(CHEMBL290365)
Affinity DataKd:  269nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474068(CHEMBL37513)
Affinity DataKd:  2.88E+3nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474033(CHEMBL416245)
Affinity DataKd:  170nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474038(CHEMBL38773)
Affinity DataKd:  1.32E+3nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474069(CHEMBL41606)
Affinity DataKd:  617nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50083200(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-[(E)...)
Affinity DataKd:  372nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474027(CHEMBL40415)
Affinity DataKd:  72nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50474070(CHEMBL289554)
Affinity DataKd:  141nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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