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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human full length CDK4/cyclinD3 (M1 to E303 residues) expressed in mammalian expression system measured after 1 hr by k...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538150(CHEMBL4647703)
Affinity DataKd:  71nMAssay Description:Binding affinity to recombinant full-length GFP-fused CDK6/His-tagged cyclin D3 (unknown origin) expressed in HEK293T cells measured after 30 mins by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM513484(4-(3,3-diethyl-7-fluoro-2-methyl-3H-indol-5-yl)-5-...)
Affinity DataIC50: 0.200nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464609(CHEMBL4289226 | US11091476, Example 20)
Affinity DataIC50: 0.240nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464633(CHEMBL4285830 | US11091476, Example 13)
Affinity DataIC50: 0.390nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464633(CHEMBL4285830 | US11091476, Example 13)
Affinity DataIC50: 0.390nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464633(CHEMBL4285830 | US11091476, Example 13)
Affinity DataIC50: 0.390nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464633(CHEMBL4285830 | US11091476, Example 13)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM601953(US11643416, Compound 55 | 2'-((4-(piperazine-1- ca...)
Affinity DataIC50: 0.400nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM601953(US11643416, Compound 55 | 2'-((4-(piperazine-1- ca...)
Affinity DataIC50: 0.400nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50: 0.420nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50: 0.420nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50: 0.420nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464632(CHEMBL4279832 | US11091476, Example 30)
Affinity DataIC50: 0.430nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464632(CHEMBL4279832 | US11091476, Example 30)
Affinity DataIC50: 0.490nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464632(CHEMBL4279832 | US11091476, Example 30)
Affinity DataIC50: 0.490nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464632(CHEMBL4279832 | US11091476, Example 30)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464636(CHEMBL4287693 | US11091476, Example 22)
Affinity DataIC50: 0.5nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444543(US10662186, Compound 63 | US10988476, Compound I-6...)
Affinity DataIC50: 0.710nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464606(CHEMBL4277900 | US11091476, Example 17)
Affinity DataIC50: 0.730nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464606(CHEMBL4277900 | US11091476, Example 17)
Affinity DataIC50: 0.730nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464606(CHEMBL4277900 | US11091476, Example 17)
Affinity DataIC50: 0.730nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464606(CHEMBL4277900 | US11091476, Example 17)
Affinity DataIC50: 0.730nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50564275(CHEMBL4778367)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-fused CDK4 (1 to 303 residues)/GST-tagged CyclinD3 (1 to 292 residues) expressed in baculo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM513489(5-Fluoro-4-(7′-fluoro-2′-methylspiro[c...)
Affinity DataIC50: 0.900nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444567(US10662186, Compound 86 | US10988476, Compound I-8...)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464623(CHEMBL4287743 | US11091476, Example 28)
Affinity DataIC50: 0.960nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444572(US10662186, Compound 91 | US10988476, Compound I-9...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464630(CHEMBL4281514 | US11091476, Example 18)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50464606(CHEMBL4277900 | US11091476, Example 17)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444580(US10662186, Compound 102 | US10988476, Compound I-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444578(US10662186, Compound 98)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464630(CHEMBL4281514 | US11091476, Example 18)
Affinity DataIC50: 1nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM642775(N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-4-(diflu...)
Affinity DataIC50: 1nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM642777(1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-4...)
Affinity DataIC50: 1nMAssay Description:Assay of Kinase Activity The inhibitory effect of compounds against the kinase CDK4/cyclin D3 was detected by Caliper Mobility Shift Assay method. Th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Human)
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464618(CHEMBL4294940 | US11091476, Example 25)
Affinity DataIC50: 1.09nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444564(US10662186, Compound 83 | US10988476, Compound I-8...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM444543(US10662186, Compound 63 | US10988476, Compound I-6...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK6 (1 to 326 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444551(US10662186, Compound 71 | US10988476, Compound I-7...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444598(US10662186, Compound 134 | US10988476, Compound I-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM444567(US10662186, Compound 86 | US10988476, Compound I-8...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK6 (1 to 326 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444597(US10662186, Compound 133 | US10988476, Compound I-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK4/Cyclin D3 expressed in Sf9 insect cells using 5-FAM-IPTSPITTTYFFFKKK as substr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human CDK6/Cyclin-D3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM444569(US10662186, Compound 88 | US10988476, Compound I-8...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK6 (1 to 326 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444591(US10662186, Compound 126 | US10988476, Compound I-...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444585(US10662186, Compound 108 | US10988476, Compound I-...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM444564(US10662186, Compound 83 | US10988476, Compound I-8...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK6 (1 to 326 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM444598(US10662186, Compound 134 | US10988476, Compound I-...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK6 (1 to 326 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM444584(US10662186, Compound 107 | US10988476, Compound I-...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CDK4 (1 to 303 residues)/cyclin D3 (1 to 292 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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