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TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514196(US11053196, Compound 4B)
Affinity DataEC50:  0.0570nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514148(US11053196, Compound 2B)
Affinity DataEC50:  0.0780nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514203(US11053196, Compound 7A-D)
Affinity DataEC50:  0.100nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514145(US11053196, Compound 1B)
Affinity DataEC50:  0.110nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514194(US11053196, Compound 4 | 4-(3-((1-(4-chlorophenyl)...)
Affinity DataEC50:  0.110nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514197(US11053196, Compound 5 | 4-(3-((1-(4-chlorophenyl)...)
Affinity DataEC50:  0.110nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514183(US11053196, Compound 3B)
Affinity DataEC50:  0.120nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514199(US11053196, Compound 5B)
Affinity DataEC50:  0.120nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514205(US11053196, Compound 8 | 4-(3-((1-(4-chloro-2-(2-h...)
Affinity DataEC50:  0.150nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514210(US11053196, Compound 11 | 4-(3-((1-(4-chlorophenyl...)
Affinity DataEC50:  0.280nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514208(US11053196, Compound 10A)
Affinity DataEC50:  0.300nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514146(US11053196, Compound 2 | 4-(3-((1-(4-chlorophenyl)...)
Affinity DataEC50:  0.380nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514202(US11053196, Compound 6B)
Affinity DataEC50:  0.390nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50588195(CHEMBL5188858)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of DENV NS2B/NS3 proMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514207(US11053196, Compound 10 | 4-(3-((1-(4-chlorophenyl...)
Affinity DataEC50:  0.520nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514178(US11053196, Compound 3 | 4-(3-((1-(4-chlorophenyl)...)
Affinity DataEC50:  0.560nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514200(US11053196, Compound 6 | 4-(3-((1-(4-fluoro-2-meth...)
Affinity DataEC50:  0.630nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514142(US11053196, Compound 1 | 4-(3-((1-(4-chlorophenyl)...)
Affinity DataEC50:  0.640nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514206(US11053196, Compound 9 | 4-(3-((1-(4-chlorophenyl)...)
Affinity DataEC50:  0.990nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514144(US11053196, Compound 1A)
Affinity DataEC50:  1.30nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514198(US11053196, Compound 5A)
Affinity DataEC50:  2.30nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50583557(CHEMBL5075993)
Affinity DataIC50: 6nMAssay Description:Inhibition of DENV NS2B-NS3 protease assessed as fluorescence emission using benzoyl-Nle-Lys-Arg-Arg-AMC as substrate preincubated with enzyme for 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50583558(CHEMBL5075008)
Affinity DataIC50: 9nMAssay Description:Inhibition of DENV NS2B-NS3 protease assessed as fluorescence emission using benzoyl-Nle-Lys-Arg-Arg-AMC as substrate preincubated with enzyme for 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514195(US11053196, Compound 4A)
Affinity DataEC50:  11nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50583559(CHEMBL5092085)
Affinity DataIC50: 12nMAssay Description:Inhibition of DENV NS2B-NS3 protease assessed as fluorescence emission using benzoyl-Nle-Lys-Arg-Arg-AMC as substrate preincubated with enzyme for 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514147(US11053196, Compound 2A)
Affinity DataEC50:  15nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50588184(CHEMBL5206054)
Affinity DataIC50: 15nMAssay Description:Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Arg-7-amino-4-methylcoumarin as substrate preincubated for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514204(US11053196, Compound 7B-D)
Affinity DataEC50:  16nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50588185(CHEMBL5205657)
Affinity DataIC50: 16nMAssay Description:Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Arg-7-amino-4-methylcoumarin as substrate preincubated for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514179(US11053196, Compound 3A)
Affinity DataEC50:  36nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514209(US11053196, Compound 10B)
Affinity DataEC50:  37nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50175864(Bz-Nle-Lys-Arg-Arg-B(OH)2 | CHEMBL199845)
Affinity DataKi:  43nMAssay Description:Inhibitory activity against CF40.NS3pro from Dengue virus type 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50185449(panduratin A | (-)-panduratin A | CHEMBL379110)
Affinity DataIC50: 57nMAssay Description:Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Arg-7-amino-4-methylcoumarin as substrate preincubated for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50583560(CHEMBL5081752)
Affinity DataIC50: 74nMAssay Description:Inhibition of DENV NS2B-NS3 protease assessed as fluorescence emission using benzoyl-Nle-Lys-Arg-Arg-AMC as substrate preincubated with enzyme for 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50623601(CHEMBL5413511)
Affinity DataKi:  78nMAssay Description:Competitive inhibition of DENV-2 NS2B-NS3 protease assessed as inhibition constant by Cheng-Prusoff plot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50623601(CHEMBL5413511)
Affinity DataIC50: 89nMAssay Description:Inhibition of DENV-2 NS2B-NS3 protease by biochemical enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50623598(CHEMBL5414400)
Affinity DataKi:  92nMAssay Description:Competitive inhibition of DENV-2 NS2B-NS3 protease assessed as inhibition constant by Cheng-Prusoff plot analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50623598(CHEMBL5414400)
Affinity DataIC50: 110nMAssay Description:Inhibition of DENV-2 NS2B-NS3 protease by biochemical enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50623600(CHEMBL5421971)
Affinity DataIC50: 120nMAssay Description:Inhibition of DENV-2 NS2B-NS3 protease by biochemical enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM60986(cid_16129778 | MLS001335996 | SMR000857330 | TANNI...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Dengue Virus 4 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM60986(cid_16129778 | MLS001335996 | SMR000857330 | TANNI...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Dengue Virus 1 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM60986(cid_16129778 | MLS001335996 | SMR000857330 | TANNI...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Dengue Virus 2 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM60986(cid_16129778 | MLS001335996 | SMR000857330 | TANNI...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Dengue Virus 3 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50603527(CHEMBL5177478)
Affinity DataIC50: 200nMAssay Description:Inhibition of 6-His tagged-G4SG4 fused DENV2 NS2B (1394 to 1440 residues) -NS3 (1476 to 1660 residue) expressed in Escherichia coli BL21 (DE3) using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50623599(CHEMBL5421390)
Affinity DataIC50: 200nMAssay Description:Inhibition of DENV-2 NS2B-NS3 protease by biochemical enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567466(CHEMBL4862682)
Affinity DataIC50: 210nMAssay Description:Inhibition Dengue serotype-2 NS3B/NS3 protease using 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50623596(CHEMBL5403309)
Affinity DataIC50: 210nMAssay Description:Inhibition of DENV-2 NS2B-NS3 protease by biochemical enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514201(US11053196, Compound 6A)
Affinity DataEC50:  250nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
Go to US Patent

TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567470(CHEMBL4862353)
Affinity DataIC50: 290nMAssay Description:Inhibition Dengue serotype-2 NS3B/NS3 protease using 7-amino-4-methylcoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50513886(CHEMBL4469970)
Affinity DataKi:  300nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
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