Compile Data Set for Download or QSAR
Report error Found 18 for UniProtKB: P29846
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29330(benzenesulfonamide derivative, 2)
Affinity DatapH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
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PubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Astex Pharmaceuticals

LigandPNGBDBM92631((3R)-3-{[(1S)-1-(4-chloro-2-fluoro-3-phenoxyphenyl...)
Affinity DataKd:  2.40E+4nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
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PubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Astex Pharmaceuticals

LigandPNGBDBM92630((3S)-N-(2-aminoethyl)-3-{[(1R)-1-(4-chloro-2-fluor...)
Affinity DataKd:  22nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29339(triphenylmethane derivative, 11)
Affinity DatapH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29337(triphenylmethane derivative, 9 | US9688816, D)
Affinity DatapH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29336(triphenylmethane derivative, 8)
Affinity DatapH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29335(triphenylmethane derivative, 7)
Affinity DatapH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29333(triphenylmethane derivative, 5)
Affinity DatapH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Astex Pharmaceuticals

LigandPNGBDBM92629((3S)-3-{[(1R)-1-(4-chloro-2-fluoro-3-phenoxyphenyl...)
Affinity DataIC50: 100nM Kd:  62nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Astex Pharmaceuticals

LigandPNGBDBM92628((1R)-1-(2,4-difluoro-3-phenoxyphenyl)propan-1-amin...)
Affinity DataIC50: 1.30E+3nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29340(triphenylmethane derivative, 12)
Affinity DataIC50: 1.01E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29331(triphenylmethane derivative, 3)
Affinity DataIC50: 1.26E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29334(triphenylmethane derivative, 6)
Affinity DataIC50: 1.39E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Astex Pharmaceuticals

LigandPNGBDBM92627((2,4-difluoro-3-phenoxyphenyl)methanamine, 3)
Affinity DataIC50: 2.00E+4nM Kd:  2.90E+4nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29332(triphenylmethane derivative, 4)
Affinity DataIC50: 2.97E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29329(BHT, 1)
Affinity DataIC50: 4.00E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
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PubMed
TargetGenome polyprotein(HCV)
National Taiwan University

LigandPNGBDBM29338(diphenol | diphenol derivative, 10)
Affinity DataIC50: 6.07E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Astex Pharmaceuticals

LigandPNGBDBM50271275(1H-indazol-7-amine, 1 | CHEMBL463676 | 1H-Indazol-...)
Affinity DataIC50: 5.00E+6nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)