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Report error Found 296 of affinity data for UniProtKB/TrEMBL: P26433
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381804(US10272079, Compound 161)
Affinity DataIC50: 0.631nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381783(US10272079, Compound 140)
Affinity DataIC50: 1.26nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381691(US10272079, Compound 65 | US10272079, Compound 48)
Affinity DataIC50: 1.41nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381762(US10272079, Compound 119)
Affinity DataIC50: 2nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381826(US10272079, Compound 003)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381742(US10272079, Compound 99)
Affinity DataIC50: 2.51nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381793(US10272079, Compound 150)
Affinity DataIC50: 2.51nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381817(US10272079, Compound 174)
Affinity DataIC50: 2.51nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381826(US10272079, Compound 003)
Affinity DataIC50: 2.51nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM426615(N,N′-(10,17-dioxo-3,6,21,24-tetraoxa-9,11,16...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381741(US10272079, Compound 98)
Affinity DataIC50: 3.98nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381751(US10272079, Compound 108)
Affinity DataIC50: 3.98nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381791(US10272079, Compound 148)
Affinity DataIC50: 3.98nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381823(US10272079, Compound 002 | US10272079, Compound 18...)
Affinity DataIC50: 3.98nMAssay Description:The ability of compounds to inhibit Rat NHE3-mediated Na+-dependent H+ antiport after application and washout was measured using a modification of th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381648(US10272079, Compound 6)
Affinity DataIC50: 4.47nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381690(US10272079, Compound 66 | US10272079, Compound 47)
Affinity DataIC50: 4.47nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381715(US10272079, Compound 72)
Affinity DataIC50: 5.01nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381794(US10272079, Compound 151)
Affinity DataIC50: 5.01nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM50601178(CHEMBL5202545)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381770(US10272079, Compound 127)
Affinity DataIC50: 6.31nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381815(US10272079, Compound 172)
Affinity DataIC50: 6.31nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM426616(N,N′-(2,2′-(2,2′-(2,2′-(1,...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381743(US10272079, Compound 100)
Affinity DataIC50: 7.94nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381785(US10272079, Compound 142)
Affinity DataIC50: 7.94nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381792(US10272079, Compound 149)
Affinity DataIC50: 7.94nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381823(US10272079, Compound 002 | US10272079, Compound 18...)
Affinity DataIC50: 9.33nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM50196789(CHEMBL3892788)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat NHE3 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381678(US10272079, Compound 35)
Affinity DataIC50: 10nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381710(US10272079, Compound 67)
Affinity DataIC50: 10nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381822(US10272079, Compound 179)
Affinity DataIC50: 10nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381823(US10272079, Compound 002 | US10272079, Compound 18...)
Affinity DataIC50: 10nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM50601179(CHEMBL5202068)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM50601180(CHEMBL5170002)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381677(US10272079, Compound 34)
Affinity DataIC50: 12.6nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381684(US10272079, Compound 41)
Affinity DataIC50: 12.6nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381724(US10272079, Compound 81)
Affinity DataIC50: 12.6nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381806(US10272079, Compound 163)
Affinity DataIC50: 12.6nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM426507(N1,N4-bis(2-(2-(2-(2-(4-(6,8-dichloro-2-methyl-1,2...)
Affinity DataIC50: 13nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM50601181(CHEMBL5170188)
Affinity DataIC50: 13nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381673(US10272079, Compound 30)
Affinity DataIC50: 15.8nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381689(US10272079, Compound 46)
Affinity DataIC50: 15.8nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381763(US10272079, Compound 120)
Affinity DataIC50: 15.8nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381789(US10272079, Compound 146)
Affinity DataIC50: 15.8nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381818(US10272079, Compound 175)
Affinity DataIC50: 15.8nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381823(US10272079, Compound 002 | US10272079, Compound 18...)
Affinity DataIC50: 16nMAssay Description:Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-HEPES buffer-mediated pH recovery in presence of NEH1 inhibitor ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381674(US10272079, Compound 31)
Affinity DataIC50: 20nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381685(US10272079, Compound 42)
Affinity DataIC50: 20nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381687(US10272079, Compound 44)
Affinity DataIC50: 20nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381698(US10272079, Compound 55)
Affinity DataIC50: 20nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium/hydrogen exchanger 3(Rat)
Ardelyx

US Patent
LigandPNGBDBM381798(US10272079, Compound 155)
Affinity DataIC50: 20nMAssay Description:Cell-based activity under Prompt Conditions. Rat or human NHE3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensiti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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