Compile Data Set for Download or QSAR
Report error Found 76 for UniProtKB: P23576
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  1.82E+5nMAssay Description:Agonist activity at rat recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha2beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247432(US9453021, 39)
Affinity DataIC50: 0.700nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247431(US9453021, 38)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247439(US9453021, 113)
Affinity DataIC50: 2.60nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247427(US9453021, 11)
Affinity DataIC50: 2.60nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247426(US9453021, 10)
Affinity DataIC50: 2.60nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247424(US9453021, 7)
Affinity DataIC50: 2.70nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247436(US9453021, 71)
Affinity DataIC50: 3nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247437(US9453021, 97)
Affinity DataIC50: 3nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247438(US9453021, 112)
Affinity DataIC50: 3.60nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247434(US9453021, 65)
Affinity DataIC50: 3.80nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247429(US9453021, 15)
Affinity DataIC50: 3.90nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247428(US9453021, 14)
Affinity DataIC50: 4nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247435(US9453021, 68)
Affinity DataIC50: 4.10nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247425(US9453021, 8)
Affinity DataIC50: 4.70nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247433(US9453021, 59)
Affinity DataIC50: 4.80nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247430(US9453021, 17)
Affinity DataIC50: 5nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/delta(Rat)
Kyowa Hakko Kirin

US Patent
LigandPNGBDBM247423(US9453021, 3)
Affinity DataIC50: 5.20nMT: 2°CAssay Description:A test compound (20 μL) diluted to 5 times of the final concentration with Binding buffer, [3H]-gabapentin diluted to 100 nmol/L with binding buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 22nMAssay Description:Inhibitory effect was measured for [3H]GABA-uptake from rat synaptosomal membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  4.80nMMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  7.80nMMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM85806(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-flumazenil from rat recombinant alpha2 GABAA receptor assessed as inhibition constant in presence of zolpidemMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM85806(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)
Affinity DataKi:  12.3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50165326(8-Chloro-2-phenyl-5H-3,3a,5,9b-tetraaza-cyclopenta...)
Affinity DataKi:  13.9nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-2-beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50165325(2-(4-Methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclope...)
Affinity DataKi:  14.3nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-2-beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A alpha-2-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50293262(2-(5-benzyl-2-hydroxyphenyl)-6-methylquinolin-4(1H...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]flumazenil in rat GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50165329(8-Chloro-2-(4-methoxy-phenyl)-5H-3,3a,5,9b-tetraaz...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-2-beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50293263(2-(5-benzyl-2-hydroxyphenyl)-6-methyl-4H-chromen-4...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]flumazenil in rat GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha2 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  20nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha-2-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50165328(2-Phenyl-5H-3,3a,5,9b-tetraaza-cyclopenta[a]naphth...)
Affinity DataKi:  27.6nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-2-beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50045050(Allopregnanolone | CHEMBL435035 | 1-(3-Hydroxy-10,...)
Affinity DataKi:  41nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM85806(6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL...)
Affinity DataKi:  73nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50206941(N-(4-bromobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide...)
Affinity DataKi:  81nMAssay Description:Displacement of [3H]flumazenil from rat GABAA alpha-2-beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50268784((R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(5-nitro-1H-in...)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A alpha-2-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50055244(N-(4-Fluoro-benzyl)-2-(1H-indol-3-yl)-2-oxo-acetam...)
Affinity DataKi:  118nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A alpha-2-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50293264(2-(5-bromo-2-hydroxyphenyl)-6-methylquinolin-4(1H)...)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]flumazenil in rat GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50101427((R)-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenyleth...)
Affinity DataKi:  121nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A alpha-2-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185264(N-((1H-pyrrol-3-yl)methyl)-2-(5-nitro-1H-indol-3-y...)
Affinity DataKi:  154nMAssay Description:Displacement of [3H]flumazenil from rat GABA-Aalpha2 receptor plus beta-2-gamma-2 in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50370710(CHEMBL1162923)
Affinity DataKi:  155nMAssay Description:Displacement of [3H]flumazenil from rat GABA-Aalpha2 receptor plus beta-2-gamma-2 in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM26266(Ambien | CHEMBL911 | ZPM | N,N-dimethyl-2-[6-methy...)
Affinity DataKi:  156nMAssay Description:Displacement of [3H]RO15-1788 from recombinant rat GABAalpha2 receptor expressed in HEK293 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM26266(Ambien | CHEMBL911 | ZPM | N,N-dimethyl-2-[6-methy...)
Affinity DataKi:  156nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha-2-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50206936(N-isopropyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetami...)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]flumazenil from rat GABAA alpha-2-beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM85683(GMA-839 | WAY-141839 | Co-2-6749 | Co 2-6749)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50122841(3-(3H-1lambda*4*-Thiophen-3-yl)-6-thiophen-3-yl-4H...)
Affinity DataKi:  200nMAssay Description:Binding affinity for recombinant rat GABA-A receptor alpha-2-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50101429(2-(1H-Indol-3-yl)-N-(4-nitro-benzyl)-2-oxo-acetami...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A alpha-2-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50268893((R/S)-N-(5-methoxy-2,3-dihydro-1H-inden-1-yl)-2-(5...)
Affinity DataKi:  231nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A alpha-2-beta-2-gamma-2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50185269(N-(furan-3-ylmethyl)-2-(5-nitro-1H-indol-3-yl)-2-o...)
Affinity DataKi:  236nMAssay Description:Displacement of [3H]flumazenil from rat GABA-Aalpha2 receptor plus beta-2-gamma-2 in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Displayed 1 to 50 (of 76 total ) | Next | Last >>
Jump to: