Compile Data Set for Download or QSAR
Report error Found 1435 for UniProtKB: P22909
LigandPNGBDBM50027035(3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)-amino]-phe...)
Affinity DataEC50:  74nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50027036((4,5-Dihydro-1H-imidazol-2-ylmethyl)-methyl-p-toly...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50027032((4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-tolyl-amine...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50027033(Cyclohexyl-(4,5-dihydro-1H-imidazol-2-ylmethyl)-p-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50027034((4,5-Dihydro-1H-imidazol-2-ylmethyl)-phenyl-p-toly...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50027037((4,5-Dihydro-1H-imidazol-2-ylmethyl)-ethyl-p-tolyl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50027031((2-Chloro-phenyl)-(4,5-dihydro-1H-imidazol-2-ylmet...)
Affinity DataEC50:  53nMAssay Description:Agonistic activity against alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonistic activity against alpha alpha-2 adrenergic receptor in isolated, field -simulated vas deferens from ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50497037(CHEMBL3248387)
Affinity DataKd:  141nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50497038(CHEMBL3248388)
Affinity DataKd:  562nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50497039(CHEMBL3248383)
Affinity DataKd:  617nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50497040(CHEMBL3248386)
Affinity DataKd:  1.02E+3nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50497041(CHEMBL3248385)
Affinity DataKd:  309nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM35234(Noradrenaline,(+) | NOREPINEPHRINE | DL-[7-3H]nore...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50042998(5-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,2-d...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50042998(5-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,2-d...)
Affinity DataEC50:  1.50E+4nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataEC50:  3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM35234(Noradrenaline,(+) | NOREPINEPHRINE | DL-[7-3H]nore...)
Affinity DataEC50:  3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataEC50: >1.00E+5nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50470860(CHEMBL105328)
Affinity DataEC50:  156nMAssay Description:50% Molar effective concentration for agonistic activity against Alpha-1 adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(CHEMBL14376 | 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazo...)
Affinity DataIC50: 0.400nMAssay Description:Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225293(CHEBI:5553 | Guanabenz | WY-8678)
Affinity DataIC50: 1.70nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019646(CHEMBL17860 | lofexidine | 2-(alpha-(2,6-Dichlorop...)
Affinity DataIC50: 2.5nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50: 3.10nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50226153(CHEMBL545092)
Affinity DataIC50: 3.30nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50226942(CHEMBL39286)
Affinity DataIC50: 3.30nMAssay Description:Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataIC50: 3.60nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50295557(CHEMBL1732 | 7-Methyl-4,6,6a,7,8,9-hexahydro-indol...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50: 3.90nMAssay Description:The compound was evaluated for the alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001922(Naphazoline | Albalon | Opcon | CHEMBL1706 | Nafaz...)
Affinity DataIC50: 4.80nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM30712(SMR000059324 | Oxymetazoline | cid_66259 | 6-tert-...)
Affinity DataIC50: 5nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50225247(CHEMBL44558)
Affinity DataIC50: 7nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50070193(1-((6aR,9R,10aR)-2-tert-Butyl-7-methyl-4,6,6a,7,8,...)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50226155(CHEMBL543684)
Affinity DataIC50: 7nMAssay Description:The compound was evaluated for the inhibition of [3H]rauwolscine binding to alpha-2-adrenergic receptor from rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019646(CHEMBL17860 | lofexidine | 2-(alpha-(2,6-Dichlorop...)
Affinity DataIC50: 7.30nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2 adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50048608(Indol-1-yl-pyridin-4-yl-amine | CHEMBL154488)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM29568([3H]-Minipress | [3H]-Furazosin | PRAZOSIN HYDROCH...)
Affinity DataIC50: 8nMAssay Description:Ability to inhibit 50% specific binding of [3H]prazosin radioligand to alpha-1 adrenergic receptor in rat cerebrocortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataIC50: 9.10nMAssay Description:Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225292(HOE-440 | Symcor Base TTS | Tiamenidine)
Affinity DataIC50: 9.10nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 10nMAssay Description:Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225294(CHEMBL146100)
Affinity DataIC50: 14nMAssay Description:Binding affinity against alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225288(Tramazoline)
Affinity DataIC50: 16nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50029051(4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | ...)
Affinity DataIC50: 16nMAssay Description:Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225290(CHEMBL146419)
Affinity DataIC50: 17nMAssay Description:50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50: 17nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]-clonidine to alpha-2-adrenoceptor.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataIC50: 17nMAssay Description:Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50225235(CHEMBL42909)
Affinity DataIC50: 19nMAssay Description:Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]clonidine from specific binding sites on rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataIC50: 20nMAssay Description:Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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