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Report error Found 50 for UniProtKB: P18505
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50503414(CHEMBL4560044)
Affinity DataEC50:  1.10E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1(S290N)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462451(CHEMBL4249205)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462452(CHEMBL4244940)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462453(CHEMBL4244933)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462446(CHEMBL4238634)
Affinity DataEC50:  1.94E+4nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462454(CHEMBL4250786)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462443(CHEMBL4238315)
Affinity DataEC50:  5.74E+4nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50503415(CHEMBL4540194)
Affinity DataEC50:  2.71E+5nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50503414(CHEMBL4560044)
Affinity DataEC50:  9.80E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50503421(CHEMBL4587325)
Affinity DataEC50:  1.00E+4nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1(S290N)gamma2S mutant receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50058046(propofol | CHEMBL526)
Affinity DataEC50:  4.40E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50503421(CHEMBL4587325)
Affinity DataEC50:  1.48E+5nMAssay Description:Positive allosteric modulation of GABA-A alpha1beta1gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as increase in GAB...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50581248(CHEMBL5090753)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GABAB1b receptor expressed in RBL cells by microplate analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50457445(CHEMBL4212818)
Affinity DataEC50:  980nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587075(CHEMBL5081682)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587076(CHEMBL5090382)
Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587077(CHEMBL5069550)
Affinity DataEC50:  1.92E+3nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587078(CHEMBL5088746)
Affinity DataEC50:  140nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587079(CHEMBL5072077)
Affinity DataEC50:  60nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462449(CHEMBL4247210)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50064417(4-Bromo-2,6-diisopropyl-phenol | CHEMBL54497)
Affinity DataEC50:  3.80E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50064420((4-Hydroxy-3,5-diisopropyl-phenyl)-phenyl-methanon...)
Affinity DataEC50:  4.70E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50064419(4-Chloro-2,6-diisopropyl-phenol | CHEMBL292402)
Affinity DataEC50:  1.00E+4nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50064424(4-Iodo-2,6-diisopropylphenol | 4-Iodo-2,6-diisopro...)
Affinity DataEC50:  1.20E+4nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50058046(propofol | CHEMBL526)
Affinity DataEC50:  8.00E+3nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50064417(4-Bromo-2,6-diisopropyl-phenol | CHEMBL54497)
Affinity DataEC50:  1.20E+4nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50064424(4-Iodo-2,6-diisopropylphenol | 4-Iodo-2,6-diisopro...)
Affinity DataEC50:  5.10E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50064420((4-Hydroxy-3,5-diisopropyl-phenyl)-phenyl-methanon...)
Affinity DataEC50:  9.00E+3nMAssay Description:Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50064419(4-Chloro-2,6-diisopropyl-phenol | CHEMBL292402)
Affinity DataEC50:  3.80E+4nMAssay Description:Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50459890(CHEBI:70620 | Bromophene)
Affinity DataEC50:  320nMAssay Description:Agonist activity at recombinant human GABAA receptor alpha1beta1gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462450(CHEMBL4238712)
Affinity DataEC50:  3.27E+4nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462448(CHEMBL4241188)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462447(CHEMBL4248377)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462445(CHEMBL4246158)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50427613(CHEMBL2322935)
Affinity DataEC50:  4.00E+4nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462444(CHEMBL4244129)
Affinity DataEC50:  9.10E+4nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1/beta-2(Human)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50462442(CHEMBL4245403)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GABA-B1/B2 receptor expressed in HEK293/Cre-luc cells assessed as inhibition of forskolin-stimulated cAMP accumulation afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588339(CHEMBL5187612)
Affinity DataIC50: 182nMAssay Description:Antagonist activity at human alpha4beta1delta GABAA receptor expressed in HEK293 Flp-In cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588336(CHEMBL5186739)
Affinity DataIC50: 1.02E+3nMAssay Description:Antagonist activity at recombinant human alpha4beta1delta GABAA receptor expressed in HEK293 Flp-In cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588337(CHEMBL5177970)
Affinity DataIC50: 1.02E+3nMAssay Description:Antagonist activity at recombinant human alpha4beta1delta GABAA receptor expressed in HEK293 Flp-In cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588340(CHEMBL5204910)
Affinity DataIC50: 1.26E+3nMAssay Description:Antagonist activity at human alpha4beta1delta GABAA receptor expressed in HEK293 Flp-In cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50580362(CHEMBL5086854)
Affinity DataIC50: 1.50E+3nMAssay Description:Negative allosteric modulation activity at human GABAA alpha1beta1gamma2 stably expressed in HEK cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50581248(CHEMBL5090753)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human GABAB1b receptor expressed in RBL cells preincubated for 5 mins followed by 3-APMPA addition by microplate analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588336(CHEMBL5186739)
Affinity DataKi:  88nMAssay Description:Antagonist activity at recombinant human alpha4beta1delta GABAA receptor expressed in HEK293 Flp-In cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588339(CHEMBL5187612)
Affinity DataKi:  195nMAssay Description:Antagonist activity at human alpha4beta1delta GABAA receptor expressed in HEK293 Flp-In cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588337(CHEMBL5177970)
Affinity DataKi:  1.03E+3nMAssay Description:Antagonist activity at recombinant human alpha4beta1delta GABAA receptor expressed in HEK293 Flp-In cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588340(CHEMBL5204910)
Affinity DataKi:  1.28E+3nMAssay Description:Antagonist activity at human alpha4beta1delta GABAA receptor expressed in HEK293 Flp-In cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGABA A receptor alpha-1/beta-1/gamma-2(Human)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50229594(N-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)aceta...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to GABA alpha-1-beta-1-gamma-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGamma-aminobutyric acid receptor subunit beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM707600(mdma)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetGamma-aminobutyric acid receptor subunit beta-1(Human)
University of Utah

Curated by ChEMBL
LigandPNGibogaine(CHEMBL1215855)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails