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Report error Found 29 for UniProtKB: P17763
TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521550(Neopentyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f...)
Affinity DataEC50:  110nMAssay Description:The Dengue virus type 2 strain New Guniea C (NG-C) and the Dengue virus type 4 strain H241 were purchased from ATCC (Manassas, Va.; item numbers VR-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM648432(US20240033256, Compound 7 | US20240033256, Compoun...)
Affinity DataEC50:  296nMAssay Description:Vero E6 cells (BCRC #60476, Bioresource Collection and Research Center, Hsinchu, Taiwan) were treated with one of Compounds 1-9 at a predetermined co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM648433(US20240033256, Compound 8)
Affinity DataEC50:  247nMAssay Description:Vero E6 cells (BCRC #60476, Bioresource Collection and Research Center, Hsinchu, Taiwan) were treated with one of Compounds 1-9 at a predetermined co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM648432(US20240033256, Compound 7 | US20240033256, Compoun...)
Affinity DataEC50:  73.1nMAssay Description:Vero E6 cells (BCRC #60476, Bioresource Collection and Research Center, Hsinchu, Taiwan) were treated with one of Compounds 1-9 at a predetermined co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM648431(US20240033256, Compound 6)
Affinity DataEC50:  1.64E+3nMAssay Description:Vero E6 cells (BCRC #60476, Bioresource Collection and Research Center, Hsinchu, Taiwan) were treated with one of Compounds 1-9 at a predetermined co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM648430(US20240033256, Compound 5)
Affinity DataEC50:  131nMAssay Description:Vero E6 cells (BCRC #60476, Bioresource Collection and Research Center, Hsinchu, Taiwan) were treated with one of Compounds 1-9 at a predetermined co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM648429(US20240033256, Compound 4)
Affinity DataEC50:  7.60nMAssay Description:Vero E6 cells (BCRC #60476, Bioresource Collection and Research Center, Hsinchu, Taiwan) were treated with one of Compounds 1-9 at a predetermined co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM648428(US20240033256, Compound 3)
Affinity DataEC50:  19.6nMAssay Description:Vero E6 cells (BCRC #60476, Bioresource Collection and Research Center, Hsinchu, Taiwan) were treated with one of Compounds 1-9 at a predetermined co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM648427(US20240033256, Compound 2)
Affinity DataEC50:  4.30nMAssay Description:Vero E6 cells (BCRC #60476, Bioresource Collection and Research Center, Hsinchu, Taiwan) were treated with one of Compounds 1-9 at a predetermined co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM648426(US20240033256, Compound 1)
Affinity DataEC50:  18.4nMAssay Description:Vero E6 cells (BCRC #60476, Bioresource Collection and Research Center, Hsinchu, Taiwan) were treated with one of Compounds 1-9 at a predetermined co...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521551(2-Ethylbutyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,...)
Affinity DataEC50:  70nMAssay Description:The Dengue virus type 2 strain New Guniea C (NG-C) and the Dengue virus type 4 strain H241 were purchased from ATCC (Manassas, Va.; item numbers VR-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521549(Diisopentyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1...)
Affinity DataEC50:  1.40nMAssay Description:The Dengue virus type 2 strain New Guniea C (NG-C) and the Dengue virus type 4 strain H241 were purchased from ATCC (Manassas, Va.; item numbers VR-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521547(Isopropyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f...)
Affinity DataEC50:  7.37E+3nMAssay Description:The Dengue virus type 2 strain New Guniea C (NG-C) and the Dengue virus type 4 strain H241 were purchased from ATCC (Manassas, Va.; item numbers VR-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521548(Isopropyl ((((2S,3 S,4R,5R)-5-(4-aminopyrrolo[2, l...)
Affinity DataEC50:  250nMAssay Description:The Dengue virus type 2 strain New Guniea C (NG-C) and the Dengue virus type 4 strain H241 were purchased from ATCC (Manassas, Va.; item numbers VR-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521546(US11149049, No. C1)
Affinity DataEC50:  130nMAssay Description:The Dengue virus type 2 strain New Guniea C (NG-C) and the Dengue virus type 4 strain H241 were purchased from ATCC (Manassas, Va.; item numbers VR-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521557(((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50: 1.10E+3nMAssay Description:The enzyme activity of dengue virus NS5 polymerase domain (DENVpol, serotype 2, New Guinea C strain) was measured as an incorporation of tritiated NM...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521555(((2S,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50: 1.10E+3nMAssay Description:The enzyme activity of dengue virus NS5 polymerase domain (DENVpol, serotype 2, New Guinea C strain) was measured as an incorporation of tritiated NM...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33251(phthalazine-based compound, 2)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33256(phthalazine-based compound, 7)
Affinity DataIC50: 2.72E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2 | US20240140975...)
Affinity DataIC50: 3.60E+3nMAssay Description:The enzyme activity of dengue virus NS5 polymerase domain (DENVpol, serotype 2, New Guinea C strain) was measured as an incorporation of tritiated NM...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein(DENV-1)
Janssen Biopharma

US Patent
LigandPNGBDBM521556(((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]tria...)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzyme activity of dengue virus NS5 polymerase domain (DENVpol, serotype 2, New Guinea C strain) was measured as an incorporation of tritiated NM...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33252(phthalazine-based compound, 3)
Affinity DataIC50: 1.07E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33259(Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877 | Bz-NKRR-H)
Affinity DataIC50: 1.18E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50: 1.23E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33257(phthalazine-based compound, 8)
Affinity DataIC50: 2.14E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33250(phthalazine-based compound, 1)
Affinity DataIC50: 3.64E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33258(phthalazine-based compound, 9)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50: 1.70E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33253(phthalazine-based compound, 4)
Affinity DataIC50: 2.33E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails Article
PubMed