Compile Data Set for Download or QSAR
Report error Found 444 of affinity data for UniProtKB/TrEMBL: P16116
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50009777(Ponalrestat (statil) | CHEMBL7679 | [3-(4-Bromo-2-...)
Affinity DataIC50: 7nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068078({5-[1-(1-Methoxy-naphthalen-2-yl)-meth-(Z)-ylidene...)
Affinity DataIC50: 9nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 9nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038840((4R)-2-[(4-bromo-2-fluorophenyl)methyl]-2,3-dihydr...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068085({5-[1-(1-Bromo-naphthalen-2-yl)-meth-(Z)-ylidene]-...)
Affinity DataIC50: 11nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038843(2-(4-bromo-2-fluorobenzyl)-6-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068083({5-[1-(3-Bromo-naphthalen-2-yl)-meth-(Z)-ylidene]-...)
Affinity DataIC50: 15nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038858(2-(1,3-benzothiazol-2-ylmethyl)-1H,2'H,5'H-spiro[i...)
Affinity DataIC50: 15nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038851(2-[3-(trifluoromethyl)benzyl]-1H,2'H,5'H-spiro[iso...)
Affinity DataIC50: 17nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038842(2-(1,3-benzothiazol-2-ylmethyl)-6-fluoro-1H,2'H,5'...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068086({5-[1-(3-Methoxy-naphthalen-2-yl)-meth-(Z)-ylidene...)
Affinity DataIC50: 20nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038844(2-(4-bromo-2-fluorobenzyl)-7-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038856(2-(4-bromo-2-fluorobenzyl)-5-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 21nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038838(2-(3,4-dichlorobenzyl)-1H,2'H,5'H-spiro[isoquinoli...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038852(2-(4-bromobenzyl)-1H,2'H,5'H-spiro[isoquinoline-4,...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038853(2-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]meth...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038862(2-(4-chlorobenzyl)-1H,2'H,5'H-spiro[isoquinoline-4...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038839(2-(4-bromo-2-fluorobenzyl)spiro[1,2,3,4-tetrahydro...)
Affinity DataIC50: 23nMAssay Description:Compound was tested in vitro for inhibition of aldose reductase activity in partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038839(2-(4-bromo-2-fluorobenzyl)spiro[1,2,3,4-tetrahydro...)
Affinity DataIC50: 23nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038857(2-(4-bromo-2-fluorobenzyl)-8-fluoro-1H,2'H,5'H-spi...)
Affinity DataIC50: 23nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50010062(CHEMBL84152 | [(2-Fluoro-6-methoxy-5-trifluorometh...)
Affinity DataIC50: 25nMAssay Description:Inhibition of aldose reductase activity was measured on partially purified bovine lens preparations incubated in presence of 50 mM glucose.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038849(2-(3-methylbenzyl)-1H,2'H,5'H-spiro[isoquinoline-4...)
Affinity DataIC50: 25nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038854(2-(4-methoxybenzyl)-1H,2'H,5'H-spiro[isoquinoline-...)
Affinity DataIC50: 25nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038861(2-[4-(trifluoromethyl)benzyl]-1H,2'H,5'H-spiro[iso...)
Affinity DataIC50: 25nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038846(6-fluoro-2-(5-trifluoromethylbenzo[d][1,3]thiazol-...)
Affinity DataIC50: 26nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038863(6-bromo-2-(4-bromo-2-fluorobenzyl)-7-methoxy-1H,2'...)
Affinity DataIC50: 28nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038841(2-(4-bromo-2-fluorobenzyl)-6-chloro-1H,2'H,5'H-spi...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038845(2-(4-bromo-2-fluorobenzyl)-5-fluoro-6-methoxy-1H,2...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038859((4S)-2-[(4-bromo-2-fluorophenyl)methyl]-6-fluoro-2...)
Affinity DataIC50: 32nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 33nMAssay Description:In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 10e -8M.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 33nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038848(2-(4-bromo-2-fluorobenzyl)-7-chloro-1H,2'H,5'H-spi...)
Affinity DataIC50: 33nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 34nMAssay Description:In vitro % decrease of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-6 M concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 35nMAssay Description:In vitro inhibition of aldose reductase from the partially purified bovine lensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 35nMAssay Description:Inhibition of bovine lens aldose reductase with DL-glyceraldehyde as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 35nMAssay Description:In vitro inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50009777(Ponalrestat (statil) | CHEMBL7679 | [3-(4-Bromo-2-...)
Affinity DataIC50: 37nMAssay Description:In vitro Inhibition of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-7 M concentrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038860(2-(4-bromo-2-fluorobenzyl)-7-methoxy-1H,2'H,5'H-sp...)
Affinity DataIC50: 37nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50038855(2-(4-bromo-2-fluorobenzyl)-6-(trifluoromethyl)-1H,...)
Affinity DataIC50: 38nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068074({5-[1-(3-Chloro-naphthalen-2-yl)-meth-(Z)-ylidene]...)
Affinity DataIC50: 48nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068075({5-[1-(1-Bromo-naphthalen-2-yl)-meth-(Z)-ylidene]-...)
Affinity DataIC50: 51nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068073({5-[1-(6-Methoxy-naphthalen-2-yl)-meth-(Z)-ylidene...)
Affinity DataIC50: 67nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50334175(2-(2,4-dioxo-5-(4-phenoxybenzylidene)thiazolidin-3...)
Affinity DataIC50: 70nMAssay Description:Inhibition of bovine lens ALR2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068076({5-[1-(1-Nitro-naphthalen-2-yl)-meth-(Z)-ylidene]-...)
Affinity DataIC50: 79nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50068080({5-[1-Naphthalen-2-yl-meth-(Z)-ylidene]-4-oxo-2-th...)
Affinity DataIC50: 96nMAssay Description:Evaluated in vitro for the inhibition of Aldose reductase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 96nMAssay Description:Evaluated for inhibition of Aldose reductase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50437452(CHEMBL2409349)
Affinity DataIC50: 99nMAssay Description:Inhibition of bovine lens aldose reductase using DL-glyceraldehyde as substrate assessed as NADPH oxidation measured for 10 mins by spectrophotometri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50022424(6',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50022470(6',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Ep811-Cnrs

Curated by ChEMBL
LigandPNGBDBM50022480(c6-chlorospiro[3,4-dihydro-2H-chromene-4,4'-(tetra...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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