Affinity DataEC50: 15nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Inhibition of rat Nav1.4 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3/4/5/8/9/10/11 subunit alpha(Rat)
Tohoku University
Curated by ChEMBL
Tohoku University
Curated by ChEMBL
Affinity DataKd: 1.80nMAssay Description:Displacement of [3H]saxitoxin from NaV in rat brain membranesMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataEC50: 146nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 1.15E+3nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 46nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 811nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 22.5nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [I757A](Rat)
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 30nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of rat Nav1.4 expressed in HEK293 cells at -80 mV holding potential by whole cell patch-clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inhibition of recombinant rat Nav1.4 expressed in CHO cells by whole cell voltage clamp electrophysiology recordingMore data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of rat Nav1.4 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [M1240A](Rat)
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 90nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [I757A](Rat)
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 100nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 135nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [I757A](Rat)
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 175nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [M1240A](Rat)
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 500nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [M1240A](Rat)
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 500nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of rat skeletal muscle Nav1.4 expressed in HEK293 cells by whole cell voltage clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [I757A](Rat)
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 700nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
TargetSodium channel protein type 4 subunit alpha [M1240A](Rat)
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 1.00E+3nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of rat Nav1.4 expressed in HEK293 cells at -80 mV holding potential by whole cell patch-clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of rat Nav1.4 expressed in HEK293 cells at -80 mV holding potential by whole cell patch-clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of rat Nav1.4 expressed in HEK293 cells at -80 mV holding potential by whole cell patch-clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.43E+4nMAssay Description:Inhibition of rat Nav1.4 expressed in Xenopus oocytes assessed as blockage of voltage-activated sodium current at holding potential of -100 mV by two...More data for this Ligand-Target Pair
Affinity DataIC50: 2.04E+5nMAssay Description:Inhibition of rat Nav1.4 expressed in Xenopus oocytes assessed as blockage of voltage-activated sodium current at holding potential of -100 mV by two...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+5nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
