Compile Data Set for Download or QSAR
Report error Found 47 of affinity data for UniProtKB/TrEMBL: P15374
LigandPNGBDBM23423(5-({[5-(1H-indol-3-yl)-4-methyl-4H-1,2,4-triazol-3...)
Affinity DatapH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23431(N-{4-[5-(furan-2-yl)-1-(furan-2-ylcarbonyl)-4,5-di...)
Affinity DatapH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50590283(CHEMBL5169766 | US20230303547, Reference Example D...)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged recombinant UCHL3 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50590284(CHEMBL5192316)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST-tagged recombinant UCHL3 (unknown origin) using Ub-Lys-TAMRA as substrate incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50431630(KRX-0401 | PERIFOSINE)
Affinity DataIC50: 50nMAssay Description:Inhibition of UCHL3 (unknown origin) assessed as reduction in RAD51 deubiquitination incubated for 4 hrsMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM53421(4-Cyclohexyl-2-phenyl-quinazoline | 4-cyclohexyl-2...)
Affinity DataIC50: 600nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50594731(CHEMBL1241028)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human UCHL3 expressed in baculovirus infected Sf9 cells using ubiquitin-AMC as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50069764(CHEMBL3407501)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of UCHL3 (unknown origin) using ubiquitin-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50594730(CHEMBL5193983)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of UCHL3 (unknown origin) incubated for 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50594729(CHEBI:27485 | CHEMBL1397260)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of UCHL3 (unknown origin) using Ub-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50538571(CHEMBL4635160)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GST-tagged UCHL3 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM65518(LDN-57444 | 668467-91-2 | 5-Chloro-1-[(2,5-dichlor...)
Affinity DataIC50: 1.41E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50442907(CHEMBL3039433 | Acetyl Isogambogic Acid)
Affinity DataIC50: 1.54E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50326012(3-(acetoxyimino)-5-bromo-1-(3,4-dichlorobenzyl)ind...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50326014(3-(acetoxyimino)-1-(3,4-dichlorobenzyl)-5-iodoindo...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM200235(Rifampicin | cid_5381226)
Affinity DataIC50: 2.48E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50594733(CHEMBL4303698)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of UCHL3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50326013(3-(acetoxyimino)-5-bromo-1-(2,5-dichlorobenzyl)ind...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM205457(Celastrol | (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-...)
Affinity DataIC50: 3.21E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50594732(CHEMBL5195092)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of recombinant human UCHL3 expressed in baculovirus infected Sf9 cells using ubiquitin-AMC as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50326015(5-(4-butylphenyl)-4-(4-isopropylphenyl)-4H-1,2,4-t...)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50242207(Mangiferin | CHEMBL455364)
Affinity DataIC50: 5.26E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM24778(Vitamin K3 | cid_4055 | 2-methyl-1,4-dihydronaphth...)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of UCHL3 in human H1299 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM24778(Vitamin K3 | cid_4055 | 2-methyl-1,4-dihydronaphth...)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of recombinant human UCHL3 expressed in baculovirus infected Sf9 cells using ubiquitin-AMC as substrate preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50552483(CHEMBL4763594)
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of recombinant human UCHL3 assessed as reduction in cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine110-glycine using...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50538549(CHEMBL4641424)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human GST-tagged UCHL3 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50270667(CHEMBL4130194)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human GST-tagged UCHL3 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23421(1-benzyl-3-hydroxy-4-[(5-methylfuran-2-yl)carbonyl...)
Affinity DataIC50: 1.03E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM65524((-)-Aricine | Heterophylline (VAN) | Quinovatine)
Affinity DataIC50: 1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23427(5-(4-fluorophenyl)-3-hydroxy-4-[(5-methylfuran-2-y...)
Affinity DataIC50: 1.23E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23426(cid_2891549 | 3-hydroxy-5-(4-methoxyphenyl)-1-(1,3...)
Affinity DataIC50: 1.54E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50271098(CHEMBL4129140)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of UCH-L3 (unknown origin) using Ub-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by flu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50608424(CHEMBL5267683)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human his tagged UCH-L3 by Westernblot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50628578(CHEMBL5432902)
Affinity DataIC50: 2.82E+5nMAssay Description:Inhibition of human UCHL3 incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM23425(N-{3-[1-acetyl-5-(thiophen-2-yl)-4,5-dihydro-1H-py...)
Affinity DataIC50: 3.31E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23424(N-cyclopropyl-2-[(4-methoxyphenyl)(4-methylbenzene...)
Affinity DataIC50: 3.34E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23429(2-[benzene(3-methoxyphenyl)sulfonamido]-N-cyclopen...)
Affinity DataIC50: 3.86E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23430(4-({[5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl...)
Affinity DataIC50: 3.87E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23428(N-cyclopropyl-2-[(4-methoxybenzene)(4-methylphenyl...)
Affinity DataIC50: 4.01E+5nMpH: 7.8 T: 2°CAssay Description:Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50628580(CHEMBL5419755)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human UCHL3 incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50628579(CHEMBL5399329)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human UCHL3 incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50628581(CHEMBL5415929)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human UCHL3 incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50628577(CHEMBL5411555)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human UCHL3 incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50628576(CHEMBL5399291)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human UCHL3 incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50628575(CHEMBL5405239)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human UCHL3 incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50326016(CHEMBL1190585 | CHEMBL541136 | 3-amino-2-benzoyl-6...)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition of UCHL3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed