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Report error Found 314 for UniProtKB: P14644
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 0.310nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50220996(CHEMBL76635)
Affinity DataIC50: 0.580nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50221003(CHEMBL432348)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50229040(CHEMBL156140)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50220998(CHEMBL76382)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50221004(CHEMBL77999)
Affinity DataIC50: 1.60nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50220993(CHEMBL78238)
Affinity DataIC50: 1.60nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50220995(CHEMBL77788)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50229041(CHEMBL351567)
Affinity DataIC50: 2.5nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228824(CHEMBL2112408)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of [3H]- rolipram binding to rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228833(CHEMBL318836)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of [3H]- rolipram binding to rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50229038(CHEMBL345917)
Affinity DataIC50: 3.20nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50221001(CHEMBL76257)
Affinity DataIC50: 3.70nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50220999(CHEMBL77745)
Affinity DataIC50: 4.5nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50471096(CHEMBL414613 | RS-14491)
Affinity DataIC50: 4.80nMAssay Description:Affinity for the high affinity rolipram binding site of phosphodiesterase (PDE IV) by [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50471096(CHEMBL414613 | RS-14491)
Affinity DataIC50: 4.80nMAssay Description:Displacement of [3H]rolipram from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50221000(CHEMBL431962)
Affinity DataIC50: 4.90nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 5nMAssay Description:Binding affinity against high affinity rolipram binding site (HARBS) was determined by displacing radioactive [3H]rolipram from brain membrane suspen...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50472190(CHEMBL167638)
Affinity DataIC50: 5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50042058((4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrroli...)
Affinity DataIC50: 5nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of [3H]rolipram binding to Wistar rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 6nMAssay Description:Affinity for the high affinity rolipram binding site of phosphodiesterase (PDE IV) by [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]rolipram from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50218245(CHEMBL65799)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50114418(N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluor...)
Affinity DataIC50: 7nMAssay Description:Inhibition of rolipram binding to PDE4 of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]rolipram binding to rat cortexMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50228829(CHEMBL2111611)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50218257(CHEMBL69874)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50221002(CHEMBL306320)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50221006(CHEMBL77358)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50221005(CHEMBL75684)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50220994(CHEMBL77177)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228825(CHEMBL2112409)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]- rolipram binding to rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50218545(Nitraquazone)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50218545(Nitraquazone)
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50072197(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Affinity DataIC50: 15nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50218246(CHEMBL68323)
Affinity DataIC50: 19nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 20nMAssay Description:Inhibition of rolipram binding to rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 20nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 20nMAssay Description:Inhibition of rolipram binding in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50219815(CHEMBL43570)
Affinity DataIC50: 20nMAssay Description:Inhibition of rolipram binding in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50218255(CHEMBL290100)
Affinity DataIC50: 20nMAssay Description:Inhibition of rolipram binding in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228822(CHEMBL2112410)
Affinity DataIC50: 21nMAssay Description:Inhibition of [3H]- rolipram binding to rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50218259(CHEMBL67898)
Affinity DataIC50: 23nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228831(CHEMBL2111610)
Affinity DataIC50: 23nMAssay Description:Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50219014(CHEMBL149559)
Affinity DataIC50: 28nMAssay Description:Inhibition of rolipram binding to rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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