Compile Data Set for Download or QSAR
Report error Found 415 of affinity data for UniProtKB/TrEMBL: P14600
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50108639(CHEMBL3596448)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50442585(GW823296X | ORVEPITANT)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50498575(CHEMBL3608939)
Affinity DataKi:  0.0420nMAssay Description:Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataKi:  0.0420nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50108638(CHEMBL3596447)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50108631(CHEMBL3596446)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataKi:  0.0540nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50439329(CHEMBL2419542)
Affinity DataKi:  0.0890nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50220136(CHEMBL1471 | 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluo...)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50290861(5-{3-[1-(3,5-Dichloro-phenyl)-ethoxy]-2-phenyl-pip...)
Affinity DataIC50: 0.0900nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50009228(CHEMBL413846 | SP (substance P) | Spantide)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of Tachykinin receptor 1 of rat forebrain tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50290865(3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-ph...)
Affinity DataIC50: 0.150nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50498572(CHEMBL3609616)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50290856(3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-ph...)
Affinity DataIC50: 0.160nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50290859(5-{3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2...)
Affinity DataIC50: 0.160nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50052280((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50: 0.180nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50002462(1,3-Diethyl-2-[3-(1,3,3-trimethyl-1,3-dihydro-indo...)
Affinity DataKd:  0.180nMAssay Description:Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21022(H-Tyr-D-Ala-Gly-Phe-Met(O)-Pro-Leu-Trp-O-3,5-Bzl(C...)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50106366(CHEMBL3596493)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50498573(CHEMBL3609620)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21021(H-Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-O-3,5-Bzl(CF3)...)
Affinity DataKi:  0.290nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50106365(CHEMBL3596492)
Affinity DataIC50: 0.290nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21021(H-Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-O-3,5-Bzl(CF3)...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50439330(CHEMBL2419541)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21021(H-Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-O-3,5-Bzl(CF3)...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50436546(CHEMBL2397481)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50436546(CHEMBL2397481)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2020
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50106358(CHEMBL3596485)
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.370nMAssay Description:Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50106367(CHEMBL3596494)
Affinity DataIC50: 0.390nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.410nMAssay Description:Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50106356(CHEMBL3596483)
Affinity DataIC50: 0.450nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50071484(N-[(R)-4-(4-Acetylamino-4-phenyl-piperidin-1-yl)-2...)
Affinity DataKi:  0.510nMAssay Description:Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50498570(CHEMBL3608938)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21023([3,5-bis(trifluoromethyl)phenyl]methyl (2S)-2-[(2S...)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50407164(CHEMBL2115376)
Affinity DataIC50: 0.600nMAssay Description:Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614481(CHEMBL5269970)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50001450(Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2 | ...)
Affinity DataIC50: 0.640nMAssay Description:Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21024(H-Tyr-D-Ala-Gly-Phe-N-Me-Nle-Pro-Leu-Trp-O-3,5-Bzl...)
Affinity DataKi:  0.710nM ΔG°:  -52.2kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50229589(Arg-Pro-Lys-Pro-Ala-Gln-Phe-Phe-Gly-Leu-Met-NH2 | ...)
Affinity DataIC50: 0.740nMAssay Description:Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50049468((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50: 0.800nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21020(H-Tyr-D-Ala-Gly-Phe-Leu-Pro-Leu-Trp-O-3,5-Bzl(CF3)...)
Affinity DataKi:  0.800nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21017([3,5-bis(trifluoromethyl)phenyl]methyl (2S)-2-[(2S...)
Affinity DataKi:  0.880nM ΔG°:  -51.7kJ/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50106359(CHEMBL3596486)
Affinity DataIC50: 0.910nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50290863(3-[1-(3,5-Dichloro-phenyl)-ethoxy]-2-phenyl-piperi...)
Affinity DataIC50: 0.910nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50108630(CHEMBL3596482)
Affinity DataIC50: 0.930nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50002462(1,3-Diethyl-2-[3-(1,3,3-trimethyl-1,3-dihydro-indo...)
Affinity DataKd:  0.970nMAssay Description:Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
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