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TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50294184(CHEMBL561640 | N-(4-chlorophenyl)-2-phenoxypropana...)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of human recombinant IMPDH2 expressed in Escherichia coli guaB assessed as NADH production by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM248094(VX-497 (2))
Affinity DataIC50: 3.5nMpH: 8.0 T: 2°CAssay Description:The assay was performed in a 100 μL final volume in 96-well UV plates (Costar, 3635) with a reaction buffer composed of 50 mM Tris-HCl (pH 8.0), 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50126275(Isoquinolin-6-yl-(5-phenyl-oxazol-2-yl)-amine | CH...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123321(7-Methoxy-6-oxazol-5-yl-2-m-tolyl-1H-quinolin-4-on...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against IMPDH II with respect to IMP and NADMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123333(2-(4-Bromo-phenyl)-7-methoxy-6-oxazol-5-yl-1H-quin...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against IMPDH II with respect to IMP and NADMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123358(7-Methoxy-2-(4-methyl-3-morpholin-4-yl-phenyl)-6-o...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123355(2-(3-Dimethylamino-indan-5-yl)-7-methoxy-6-oxazol-...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123335(2-(3,4-Dimethyl-phenyl)-7-methoxy-6-oxazol-5-yl-1H...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123332(7-Methoxy-2-(4-methoxy-phenyl)-6-oxazol-5-yl-1H-qu...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123317(7-Methoxy-6-oxazol-5-yl-2-p-tolyl-1H-quinolin-4-on...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50222633(CHEMBL356881)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50222630(CHEMBL153481)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123355(2-(3-Dimethylamino-indan-5-yl)-7-methoxy-6-oxazol-...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123353(2-(3-Azetidin-1-yl-indan-5-yl)-7-methoxy-6-oxazol-...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50133731({3-[3-(4-Cyano-3-methoxy-phenyl)-ureido]-benzyl}-c...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123355(2-(3-Dimethylamino-indan-5-yl)-7-methoxy-6-oxazol-...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50120529(Acetic acid (methyl-{2-[2-(3-oxazol-5-yl-1H-indol-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50120529(Acetic acid (methyl-{2-[2-(3-oxazol-5-yl-1H-indol-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM19284(N-{2-[3-(dimethylsulfamoyl)phenyl]propan-2-yl}-2-f...)
Affinity DataIC50: 7.90nM EC50:  380nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123324(7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one...)
Affinity DataIC50: 8nMAssay Description:Inhibition of 5'-inosine monophosphate dehydrogenase type II (IMPDH II)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123324(7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one...)
Affinity DataIC50: 8nMAssay Description:Inhibition of inosine-5'-monophosphate dehydrogenase 2.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123324(7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50054042((E)-6-(4-Hydroxy-7-methyl-3-oxo-6-vinyl-1,3-dihydr...)
Affinity DataIC50: 8.51nMAssay Description:Inhibition of human recombinant inosine monophosphate dehydrogenase type II. More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123320(7-Methoxy-6-oxazol-5-yl-2-thiophen-3-yl-1H-quinoli...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against IMPDH II with respect to IMP and NADMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM19283(N-{2-[4-(dimethylsulfamoyl)phenyl]propan-2-yl}-2-f...)
Affinity DataIC50: 10nM EC50:  660nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50112565(N-tert-Butyl-N'-(3-methoxy-4-oxazol-5-yl-phenyl)-o...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50102249({3-[3-(3-Methoxy-4-oxazol-5-yl-phenyl)-ureido]-ben...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50112565(N-tert-Butyl-N'-(3-methoxy-4-oxazol-5-yl-phenyl)-o...)
Affinity DataIC50: 10nMAssay Description:Inhibition of inosine-5'-monophosphate dehydrogenase 2.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50102249({3-[3-(3-Methoxy-4-oxazol-5-yl-phenyl)-ureido]-ben...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50222632(CHEMBL356236)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM19277(2-fluoro-9-oxo-N-(2-phenylpropan-2-yl)-9,10-dihydr...)
Affinity DataIC50: 11nM EC50:  830nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM19279(2-fluoro-9-oxo-N-[2-(pyridin-3-yl)propan-2-yl]-9,1...)
Affinity DataIC50: 11nM EC50:  420nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM19292(2-fluoro-N-{2-[5-methyl-6-(morpholin-4-yl)pyridin-...)
Affinity DataIC50: 11nM EC50:  870nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50120535(1-(3-Oxazol-5-yl-1H-indol-6-yl)-3-p-tolyl-urea | C...)
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123350(Dimethyl-carbamic acid 6-(7-methoxy-6-oxazol-5-yl-...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50120535(1-(3-Oxazol-5-yl-1H-indol-6-yl)-3-p-tolyl-urea | C...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50102249({3-[3-(3-Methoxy-4-oxazol-5-yl-phenyl)-ureido]-ben...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50113219(N-{2-[2-(3-Methoxy-4-oxazol-5-yl-phenylamino)-oxaz...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM19281(2-fluoro-N-[2-(4-methanesulfonylphenyl)propan-2-yl...)
Affinity DataIC50: 12nM EC50:  480nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM19282(2-fluoro-N-[2-(3-methanesulfonylphenyl)propan-2-yl...)
Affinity DataIC50: 12nM EC50:  580nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123348(2-Methoxy-N-[6-(7-methoxy-6-oxazol-5-yl-4-oxo-1,4-...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123376(7-Methoxy-2-(3-methylamino-indan-5-yl)-6-oxazol-5-...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human IMPDH2 expressed in Escherichia coli strain BL21(DE3) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50113230(BMS-337197 | N-{2-[2-(3-Methoxy-4-oxazol-5-yl-phen...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50054021((E)-6-(6-Ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydr...)
Affinity DataIC50: 12.6nMAssay Description:Inhibition of human recombinant inosine monophosphate dehydrogenase type II. More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50123361(7-Methoxy-6-oxazol-5-yl-2-(3-pyrrolidin-1-yl-indan...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against inosine monophosphate dehydrogenase IMPDH IIMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50160371(7-Methoxy-6-oxazol-5-yl-3-(2-pyridin-4-yl-ethyl)-2...)
Affinity DataIC50: 13nMAssay Description:In vitro inhibitory concentration against inosine-5'-monophosphate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50185589((E)-2-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Brandeis University

Curated by ChEMBL
LigandPNGBDBM50113215(N-{2-[2-(3-Methoxy-4-oxazol-5-yl-phenylamino)-oxaz...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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