Compile Data Set for Download or QSAR
Report error Found 45 of affinity data for UniProtKB/TrEMBL: P10398
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507707(CHEMBL4466555)
Affinity DataIC50: 1nMAssay Description:Inhibition of human ARAF using MEK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50096279(CHEMBL3577124)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM704179(US12139488, Example 353)
Affinity DataIC50: 5.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM704187(Example 524 (Iron Metal as Reducing Agent for Step...)
Affinity DataIC50: 5.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM704198((Table 4) | US12139488, Example 679)
Affinity DataIC50: 5.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM372967(US9895376, Compound 2.2a | US10576087, Compound 2....)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of ARAF (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507709(CHEMBL4438236)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGUS12139488, Example BGB283(US9895376, Compound 2.2b | US10576087, Compound 2....)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In DepthDetails

TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGUS12139488, Example LXH254(US9694016, 1156 | US10245267, Example 1156 | US107...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In DepthDetails

TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGUS12139488, Example Belvarafenib(US9156852, 116 | USRE47451, Example 116)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In DepthDetails

TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human ARAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50085415(G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...)
Affinity DataIC50: 14.6nMAssay Description:Inhibition of human ARAF using MEK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264689(CHEMBL4060057)
Affinity DataIC50: 18nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264719(CHEMBL4075036)
Affinity DataIC50: 25nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50469204(CHEMBL4282601)
Affinity DataIC50: 25nMAssay Description:Inhibition of ARAF (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50428286(GSK2118436A | DABRAFENIB)
Affinity DataIC50: 26nMAssay Description:Competitive binding affinity to ARAF in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50469203(CHEMBL4289810)
Affinity DataIC50: 30nMAssay Description:Inhibition of ARAF (unknown origin) after 20 mins in presence of 33P-gamma-ATP by hotspot kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM192503(US9187474, 18)
Affinity DataIC50: 31nMAssay Description:Sample preparation: A375 cells from ATCC are lysed by sonication in commercially available lysis buffer, cleared by centrifugation, and the resulting...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264716(CHEMBL4087837)
Affinity DataIC50: 34nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507705(CHEMBL4436132)
Affinity DataIC50: 36nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264730(CHEMBL4080362)
Affinity DataIC50: 38nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264691(CHEMBL4104590)
Affinity DataIC50: 41nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264718(CHEMBL4085294)
Affinity DataIC50: 42nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264690(CHEMBL4066939)
Affinity DataIC50: 43nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50096279(CHEMBL3577124)
Affinity DataIC50: 44nMAssay Description:Competitive binding affinity to ARAF in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50096279(CHEMBL3577124)
Affinity DataIC50: 44nMAssay Description:Inhibition of desthiobiotin-ATP acylphosphate probe binding to A-Raf in human A375 cells by MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264717(CHEMBL4082425)
Affinity DataIC50: 47nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507704(CHEMBL4586402)
Affinity DataIC50: 52nMAssay Description:Inhibition of ARaf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264731(CHEMBL4060531)
Affinity DataIC50: 57nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM192504(US9187474, 76)
Affinity DataIC50: 120nMAssay Description:Sample preparation: A375 cells from ATCC are lysed by sonication in commercially available lysis buffer, cleared by centrifugation, and the resulting...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50523706(CHEMBL4542639)
Affinity DataIC50: 183nMAssay Description:Inhibition of human ARAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50264729(CHEMBL4101882)
Affinity DataIC50: 194nMAssay Description:Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50523707(CHEMBL4447617)
Affinity DataIC50: 211nMAssay Description:Inhibition of human ARAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50507705(CHEMBL4436132)
Affinity DataIC50: 276nMAssay Description:Inhibition of desthiobiotin-ATP acylphosphate probe binding to A-Raf in human A375 cells by MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 950nMAssay Description:Competitive binding affinity to ARAF in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50571440(CHEMBL4873571)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human A-Raf (273 to end residues) using myelin basic protein as substrate incubated for 40 mins in presence of [gamma-33ATP...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of desthiobiotin-ATP acylphosphate probe binding to A-Raf in human A375 cells by MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574708(CHEMBL4866102)
Affinity DataIC50: 7.06E+3nMAssay Description:Inhibition of A-RAF (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant A-Raf (273 to end residues) using myelin as substrate incubated for 40 mins in presence of [gamma-33ATP] by radiometr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50401152(CHEMBL2205766)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ARAFMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase A-Raf(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ARAF using MEK1 as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed