Compile Data Set for Download or QSAR
Report error Found 115 of affinity data for UniProtKB/TrEMBL: P09668
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167290((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)
Affinity DataKi:  0.460nMAssay Description:Inhibition constant against human cathepsin H using L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167289((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)
Affinity DataKi:  1.40nMAssay Description:Inhibition constant against human cathepsin H using L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148298(((S)-1-Formyl-pentyl)-carbamic acid (R)-1-benzyl-2...)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148296((S)-1-phenylpropan-2-yl (S)-1-oxohexan-2-ylcarbama...)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50163831((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM397464(US9988375, Compound 43 | US10676470, Compound 43 |...)
Affinity DataIC50: 110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM397464(US9988375, Compound 43 | US10676470, Compound 43 |...)
Affinity DataIC50: 110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM397464(US9988375, Compound 43 | US10676470, Compound 43 |...)
Affinity DataIC50: 110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM397464(US9988375, Compound 43 | US10676470, Compound 43 |...)
Affinity DataIC50: 110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50247192((S)-2-amino-N-((S)-5-phenyl-1-(phenylsulfonyl)pent...)
Affinity DataKi:  137nMAssay Description:Inhibition of human recombinant cathepsin H by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50250152(3-acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroq...)
Affinity DataIC50: 145nMAssay Description:Inhibition of human liver cathepsin H after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant cathepsin H after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50177501({(S)-1-[(morpholine-4-carbonyl)-hydrazonomethyl]-p...)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50177494({(S)-1-[(morpholine-4-carbonyl)-hydrazonomethyl]-p...)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152524([1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1...)
Affinity DataIC50: 500nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50165424((S)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl (S)-1,...)
Affinity DataIC50: 500nMAssay Description:Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50: 560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50163832((1S)-2-cyclohexyl-1-methylethyl (2S)-1-cyanopyrrol...)
Affinity DataIC50: 580nMAssay Description:Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50464764(CHEMBL4287663)
Affinity DataKi:  1.30E+3nMAssay Description:Reversible competitive inhibition of human cathepsin H using fluorogenic AMC-derived peptide substrate assessed as reduction in residual activity pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243232(N~2~-(MORPHOLIN-4-YLCARBONYL)-N~1~-[(1S,2E)-1-(2-P...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human recombinant cathepsin H by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50: 1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50: 1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50: 1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50: 1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152521((1-phenethylcyclobutyl)methyl(S)-1,2-dioxo-1-((R)-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50165425([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152526((1-(3-phenylpropyl)cyclobutyl)methyl(S)-1,2-dioxo-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50201701(cis-4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3....)
Affinity DataIC50: 2.65E+3nMAssay Description:Inhibition of human recombinant cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50186088((S)-2-amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human recombinant cathepsin H by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152522([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50165420([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152523([(S)-5-[(Morpholine-4-carbonyl)-amino]-1-((R)-1-ph...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152532([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152525([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152530(P2,P3 Ketoamide derivative | CHEMBL186650)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152527([(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-car...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50201700((1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-...)
Affinity DataIC50: 6.59E+3nMAssay Description:Inhibition of human recombinant cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50464766(CHEMBL4292287)
Affinity DataKi:  7.00E+3nMAssay Description:Reversible competitive inhibition of human cathepsin H using fluorogenic AMC-derived peptide substrate assessed as reduction in residual activity pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50163838(TCMDC-138496 | (1-Cyano-pyrrolidin-3-yl)-carbamic ...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of human liver cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of human liver cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50270029(2-Amino-N-[(S)-3-diazo-1-(4-iodo-benzyl)-2-oxo-pro...)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of human recombinant cathepsin H after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453329(BDBM553832 | US10730826, Compound 47a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453330(US10730826, Compound 50a | BDBM553833)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50201705((1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPro-cathepsin H(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453332(BDBM553835 | US10730826, Compound 69a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

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