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TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  1.30E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  4.40E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataKd:  5.60E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataKd:  6.20E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  3.80E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  650nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  690nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  190nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  670nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  5.70E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM81377(FIIN-1)
Affinity DataKd:  1.00E+3nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM81378(FRIN-1)
Affinity DataKd:  1.40E+3nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM149701(US8975282, 8)
Affinity DataKd:  2.40nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 .mu.M KKKSPGEYVNIEFG, 10 mM MgAcetate and [.gamma.-.sup.33P-ATP] (specific activity appr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM149702(US8975282, 10)
Affinity DataKd:  200nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 .mu.M KKKSPGEYVNIEFG, 10 mM MgAcetate and [.gamma.-.sup.33P-ATP] (specific activity appr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM149703(US8975282, 11)
Affinity DataKd:  0.5nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 .mu.M KKKSPGEYVNIEFG, 10 mM MgAcetate and [.gamma.-.sup.33P-ATP] (specific activity appr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM149704(US8975282, 16)
Affinity DataKd:  0.210nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 .mu.M KKKSPGEYVNIEFG, 10 mM MgAcetate and [.gamma.-.sup.33P-ATP] (specific activity appr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  1.10E+3nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  690nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  812nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged MET (unknown origin) (956 to 1390 residues) expressed in baculovirus infec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  930nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged MET (unknown origin) (956 to 1390 residues) expressed in baculovirus infec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536471(CHEMBL4532610)
Affinity DataEC50:  5.20nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536472(CHEMBL4581168)
Affinity DataEC50:  1.90nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536473(CHEMBL4570217)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536474(CHEMBL4536783)
Affinity DataEC50:  38nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536475(CHEMBL4522638)
Affinity DataEC50:  18nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536476(CHEMBL4549233)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536477(CHEMBL4585798)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536478(CHEMBL4554813)
Affinity DataEC50:  4.90nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536480(CHEMBL4568802)
Affinity DataEC50:  12nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536481(CHEMBL4566100)
Affinity DataEC50:  3.40nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536482(CHEMBL4519755)
Affinity DataEC50:  17nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536483(CHEMBL4524262)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536484(CHEMBL4540942)
Affinity DataEC50:  4.90nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50396934(CHEMBL2170804 | CHEMBL2001019 | US9062045, Compara...)
Affinity DataEC50:  0.300nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536485(CHEMBL4519339)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536486(CHEMBL4559256)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536487(CHEMBL4557414)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536488(CHEMBL4556499)
Affinity DataEC50:  13nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536489(CHEMBL4541026)
Affinity DataEC50:  16nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536490(CHEMBL4565038)
Affinity DataEC50:  40nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536491(CHEMBL4554402)
Affinity DataEC50:  81nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536492(CHEMBL4551055)
Affinity DataEC50:  25nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536493(CHEMBL4558786)
Affinity DataEC50:  2.5nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536494(CHEMBL4564491)
Affinity DataEC50:  38nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536495(CHEMBL4567631)
Affinity DataEC50:  11nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536496(CHEMBL4541607)
Affinity DataEC50:  6.40nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536497(CHEMBL4560881)
Affinity DataEC50:  4nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536498(CHEMBL4591638)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536499(CHEMBL4524495)
Affinity DataEC50:  24nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50536500(CHEMBL4483635)
Affinity DataEC50:  92nMAssay Description:Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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