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TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM195591(US9216974,Resorufin | US9333197, Resorufin)
Affinity DataKd:  225nMAssay Description:To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 uM methoxy-X34 in th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM195600(US9216974, WC-5-1)
Affinity DataKd:  828nMAssay Description:To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 uM methoxy-X34 in th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM195599(US9216974, WC-5-2)
Affinity DataKd:  800nMAssay Description:To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 uM methoxy-X34 in th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM195585(US9216974, WC-5-3)
Affinity DataKd:  2.38E+3nMAssay Description:To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 uM methoxy-X34 in th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM195598(US9216974, WC-5-4)
Affinity DataKd:  537nMAssay Description:To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 uM methoxy-X34 in th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM195595(US9216974, WC-5-9)
Affinity DataKd:  927nMAssay Description:To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 uM methoxy-X34 in th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM195588(US9216974, WC-5-31)
Affinity DataKd: >1.00E+4nMAssay Description:To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 uM methoxy-X34 in th...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50163996(ethyl 4-(4-chlorophenylsulfonyl)-4-(2-methoxypheny...)
Affinity DataEC50:  1.03E+3nMAssay Description:In vitro inhibition of amyloid precursor protein 695 activity in CHO cells expressing human APPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM28961(ethyl 4-[(4-chlorobenzene)sulfonyl]-4-phenylpiperi...)
Affinity DataEC50:  2.09E+4nMAssay Description:In vitro effective concentration against beta amyloid protein 42 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50163996(ethyl 4-(4-chlorophenylsulfonyl)-4-(2-methoxypheny...)
Affinity DataEC50:  530nMAssay Description:In vitro reduction of Swedish NL mutant amyloid precursor protein activity expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50163997(4-(4-Methoxy-benzenesulfonyl)-4-phenyl-piperidine-...)
Affinity DataEC50:  9.70E+4nMAssay Description:In vitro effective concentration against beta amyloid protein 40 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50163996(ethyl 4-(4-chlorophenylsulfonyl)-4-(2-methoxypheny...)
Affinity DataEC50:  5.00E+3nMAssay Description:In vitro effective concentration against beta amyloid protein 42 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM28960(BMCL18464 Compound 14 | (2R)-2-{[5-chloro-2-(hydro...)
Affinity DataEC50:  100nMAssay Description:In vitro effective concentration against beta amyloid protein 40 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50163998(4-(4-Methoxy-benzenesulfonyl)-4-o-tolyl-piperidine...)
Affinity DataEC50:  2.45E+4nMAssay Description:In vitro effective concentration against beta amyloid protein 40 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50163999(4-(4-Chloro-benzenesulfonyl)-4-o-tolyl-piperidine-...)
Affinity DataEC50:  3.70E+3nMAssay Description:In vitro effective concentration against beta amyloid protein 42 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50164000(4-(4-Methoxy-benzenesulfonyl)-4-(2-methoxy-phenyl)...)
Affinity DataEC50:  5.06E+4nMAssay Description:In vitro effective concentration against beta amyloid protein 40 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50163996(ethyl 4-(4-chlorophenylsulfonyl)-4-(2-methoxypheny...)
Affinity DataEC50:  3.50E+3nMAssay Description:In vitro effective concentration against beta amyloid protein 40 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM28961(ethyl 4-[(4-chlorobenzene)sulfonyl]-4-phenylpiperi...)
Affinity DataEC50:  1.22E+4nMAssay Description:In vitro effective concentration against beta amyloid protein 40 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50163999(4-(4-Chloro-benzenesulfonyl)-4-o-tolyl-piperidine-...)
Affinity DataEC50:  2.70E+3nMAssay Description:In vitro effective concentration against beta amyloid protein 40 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50163996(ethyl 4-(4-chlorophenylsulfonyl)-4-(2-methoxypheny...)
Affinity DataEC50:  640nMAssay Description:In vitro elevation of beta C-terminal fragment (Ct-99) in CHO cells expressing mutant Swedish NL human APPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50164001(4-Benzenesulfonyl-4-o-tolyl-piperidine-1-carboxyli...)
Affinity DataEC50:  4.86E+4nMAssay Description:In vitro effective concentration against beta amyloid protein 40 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50164002(4-Benzenesulfonyl-4-(2-methoxy-phenyl)-piperidine-...)
Affinity DataEC50:  6.27E+4nMAssay Description:In vitro effective concentration against beta amyloid protein 40 in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50103964(CHEMBL3593932)
Affinity DataKd:  271nMAssay Description:Binding affinity amyloid beta (1 to 42) (unknown origin) expressed in Escherichia coli after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50305469(N-(3-(2-amino-4-cyclohexyl-1-methyl-5-oxo-4,5-dihy...)
Affinity DataEC50:  180nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50300710(8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrim...)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50300229(2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-on...)
Affinity DataEC50:  4.17E+3nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50305467(2-amino-4-cyclohexyl-1-methyl-4-phenyl-1H-imidazol...)
Affinity DataEC50:  810nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50305483(2-amino-4,4-dicyclohexyl-1-methyl-1H-imidazol-5(4H...)
Affinity DataEC50:  1.03E+3nMAssay Description:Inhibition of human recombinant APP expressed in CHO-K1 cells assessed as reduction of amyloid beta level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50314993(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-...)
Affinity DataEC50:  190nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50314994(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-...)
Affinity DataEC50:  440nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50314995(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50314996(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataEC50:  1.36E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50314997(N-(4-(1-((6-aminopyridin-2-yl)methyl)-5-(2-chlorop...)
Affinity DataEC50:  8.60E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50314998(6-((2-(2-chlorophenyl)-5-(4-(thiophen-2-yloxy)phen...)
Affinity DataEC50:  1.18E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50314999(6-((2-(2-chlorophenyl)-5-(4-(pyrazin-2-yloxy)pheny...)
Affinity DataEC50:  1.33E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50315000(6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phe...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50315001(6-((2-(2-chlorophenyl)-5-(4-(pyridin-4-yloxy)pheny...)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50315002(6-((2-(2-chlorophenyl)-5-(4-phenoxyphenyl)-1H-pyrr...)
Affinity DataEC50:  9.20E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50315003(N-allyl-4-(1-((6-aminopyridin-2-yl)methyl)-5-pheny...)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50315004(4-(4-{1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorop...)
Affinity DataEC50:  5.20E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50315005(6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-...)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50315006(6-((2-(2-chlorophenyl)-5-(4-methoxyphenyl)-1H-pyrr...)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50315007(6-((2,5-diphenyl-1H-pyrrol-1-yl)methyl)pyridin-2-a...)
Affinity DataEC50:  1.54E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50276904(CHEMBL4167402)
Affinity DataEC50:  8.01E+4nMAssay Description:Inhibition of QD-labeled amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by inverted fluorescence microscopic methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50276905(CHEMBL4162421)
Affinity DataEC50:  4.54E+6nMAssay Description:Inhibition of QD-labeled amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by inverted fluorescence microscopic methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50276906(CHEMBL4166279)
Affinity DataEC50:  2.74E+5nMAssay Description:Inhibition of QD-labeled amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by inverted fluorescence microscopic methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50276907(CHEMBL4165903)
Affinity DataEC50:  2.82E+3nMAssay Description:Inhibition of QD-labeled amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by inverted fluorescence microscopic methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50276908(CHEMBL2088769 | Pentyl 3-(3,4-Dihydroxyphenyl)Acry...)
Affinity DataEC50:  2.58E+3nMAssay Description:Inhibition of QD-labeled amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by inverted fluorescence microscopic methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50276909(CHEMBL3357165)
Affinity DataEC50:  1.49E+4nMAssay Description:Inhibition of QD-labeled amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by inverted fluorescence microscopic methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Washington University

US Patent
LigandPNGBDBM50276910(CHEMBL4164790)
Affinity DataEC50:  3.95E+4nMAssay Description:Inhibition of QD-labeled amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by inverted fluorescence microscopic methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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