Affinity DataKd: 3nMAssay Description:Inhibition of rat Nav1.2 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
Affinity DataKd: 400nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 55nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 5.30nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 1.40E+3nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 290nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 500nMAssay Description:Binding affinity to rat voltage-gated sodium channel Nav1.2 expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3/4/5/8/9/10/11 subunit alpha(Rat)
Tohoku University
Curated by ChEMBL
Tohoku University
Curated by ChEMBL
Affinity DataKd: 1.80nMAssay Description:Displacement of [3H]saxitoxin from NaV in rat brain membranesMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataEC50: 360nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 98nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 138nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 134nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 156nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIAMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of rat NaV1.2 channelMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Displacement of [3H]batrachotoxinin from rat sodium channel type 2A subunit expressed in CHO-CNa2A cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 76nMAssay Description:Inhibitory concentration against [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in vitro in rat cerebral cortex membrane at 1...More data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Inhibitory concentration against [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in vitro in rat cerebral cortex membrane at 1...More data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 105nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
