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Report error Found 256 for UniProtKB: P04774
TargetSodium channel protein type 1 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50242400(CCNCSSKWCRDHSRCC | CHEMBL525818)
Affinity DataKd:  290nMAssay Description:Inhibition of rat Nav1.1 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]saxitoxin from NaV in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223720(CHEMBL332257)
Affinity DataIC50: 8nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223731(CHEMBL118603)
Affinity DataIC50: 16nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223721(CHEMBL331513)
Affinity DataIC50: 19nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223726(CHEMBL117331)
Affinity DataIC50: 25nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223735(CHEMBL119139)
Affinity DataIC50: 26nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223734(CHEMBL331942)
Affinity DataIC50: 28nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223733(CHEMBL120306)
Affinity DataIC50: 30nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223722(CHEMBL334104)
Affinity DataIC50: 70nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143966(2-Chloro-N-[2-{4-[3-(4-fluoro-phenoxy)-2-hydroxy-p...)
Affinity DataIC50: 76nMAssay Description:Inhibitory concentration against [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in vitro in rat cerebral cortex membrane at 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223723(CHEMBL119494)
Affinity DataIC50: 86nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143963(N-[2-{4-[3-(4-Bromo-phenoxy)-2-hydroxy-propyl]-pip...)
Affinity DataIC50: 95nMAssay Description:Inhibitory concentration against [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in vitro in rat cerebral cortex membrane at 1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223725(CHEMBL118682)
Affinity DataIC50: 100nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50082319((R)-1-Phenoxy-3-[4-(4-phenoxy-phenyl)-piperidin-1-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50082324((S)-1-Phenoxy-3-[4-(4-phenoxy-phenyl)-piperidin-1-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50473876(CHEMBL2112614)
Affinity DataIC50: 134nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223729(CHEMBL418863)
Affinity DataIC50: 146nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143950(N-Benzyl-2-{4-[3-(2,6-dimethyl-phenoxy)-2-hydroxy-...)
Affinity DataIC50: 149nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143952(N-{1-[2-Hydroxy-3-(4-methoxy-phenoxy)-propyl]-pipe...)
Affinity DataIC50: 183nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50082323(4-[4-(4-Fluoro-benzyl)-phenyl]-1-((E)-3-phenyl-all...)
Affinity DataIC50: 190nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143954(N-(4-Fluoro-phenyl)-N-{1-[2-hydroxy-3-(4-methoxy-p...)
Affinity DataIC50: 191nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143958(N-(4-Fluoro-phenyl)-N-{1-[2-hydroxy-3-(4-methoxy-p...)
Affinity DataIC50: 194nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143962(N-(2-{4-[3-(4-Chloro-phenoxy)-2-hydroxy-propyl]-pi...)
Affinity DataIC50: 208nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143975(2-(4-Fluoro-phenyl)-2-{4-[2-hydroxy-3-(4-methoxy-p...)
Affinity DataIC50: 214nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143964(4-Chloro-N-(4-fluoro-phenyl)-N-{1-[2-hydroxy-3-(4-...)
Affinity DataIC50: 214nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50082319((R)-1-Phenoxy-3-[4-(4-phenoxy-phenyl)-piperidin-1-...)
Affinity DataIC50: 220nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143945(4-Chloro-N-{1-[2-hydroxy-3-(4-methoxy-phenoxy)-pro...)
Affinity DataIC50: 228nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143970(N-(2-{4-[2-Hydroxy-3-(4-methoxy-phenoxy)-propyl]-p...)
Affinity DataIC50: 253nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143957(N-Benzyl-2-(4-fluoro-phenyl)-2-{4-[2-hydroxy-3-(4-...)
Affinity DataIC50: 254nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50473882(CHEMBL126206)
Affinity DataIC50: 255nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143961(N-{1-[2-Hydroxy-3-(4-methoxy-phenoxy)-propyl]-pipe...)
Affinity DataIC50: 261nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50017702(cid_6365505 | 1-(bis(4-fluorophenyl)methyl)-4-cinn...)
Affinity DataIC50: 290nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143949(N-Benzyl-2-{4-[3-(2,6-dimethyl-phenoxy)-2-hydroxy-...)
Affinity DataIC50: 296nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50082320(4-(4-Phenoxy-phenyl)-1-((E)-3-phenyl-allyl)-piperi...)
Affinity DataIC50: 320nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50223732(CHEMBL118626)
Affinity DataIC50: 322nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50473870(CHEMBL2112617)
Affinity DataIC50: 322nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143967(N-Benzyl-2-{4-[3-(2,6-dimethyl-phenoxy)-2-hydroxy-...)
Affinity DataIC50: 325nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143976(2-{4-[3-(2,6-Dimethyl-phenoxy)-2-hydroxy-propyl]-p...)
Affinity DataIC50: 343nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143956(2-{4-[3-(2,6-Dimethyl-phenoxy)-2-hydroxy-propyl]-p...)
Affinity DataIC50: 351nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143974(2-{4-[3-(2,6-Dimethyl-phenoxy)-2-hydroxy-propyl]-p...)
Affinity DataIC50: 355nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143955(2-{4-[2-Hydroxy-3-(4-methoxy-phenoxy)-propyl]-pipe...)
Affinity DataIC50: 359nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50082322(1-{4-[4-(4-Fluoro-benzyl)-phenyl]-piperidin-1-yl}-...)
Affinity DataIC50: 360nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143965(N-(2-{4-[3-(4-Chloro-phenoxy)-2-hydroxy-propyl]-pi...)
Affinity DataIC50: 363nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143947(4-Fluoro-N-{2-[4-(2-hydroxy-3-phenoxy-propyl)-pipe...)
Affinity DataIC50: 363nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50473868(CHEMBL339108)
Affinity DataIC50: 379nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143951(1-Allyloxy-3-{4-[(4-chloro-phenyl)-phenyl-methyl]-...)
Affinity DataIC50: 401nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50143971(N-Benzyl-2-{4-[2-hydroxy-3-(4-methoxy-phenoxy)-pro...)
Affinity DataIC50: 429nMAssay Description:In vitro inhibition of [3H]batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50473883(CHEMBL2111817)
Affinity DataIC50: 452nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Institut Henri Beaufour

Curated by ChEMBL
LigandPNGBDBM50473869(Lifarizine | RS-87476-000)
Affinity DataIC50: 494nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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