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TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003740(CHEMBL134926 | amino{[4-(2-methylene-6-oxotetrahyd...)
Affinity DataKon:  0.0000330M-1s-1Assay Description:Decylation rate constant against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50230149(CHEMBL1161040)
Affinity DataKon:  0.000333M-1s-1Assay Description:Decylation rate constant against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003739(CHEMBL134927 | (Lactone3)N-[4-(4-Guanidino-phenyl)...)
Affinity DataKon:  0.000250M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against the enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003741(CHEMBL137269 | N-[4-(2-Iodomethylene-6-oxo-tetrahy...)
Affinity DataKon:  0.000330M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against the enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003740(CHEMBL134926 | amino{[4-(2-methylene-6-oxotetrahyd...)
Affinity DataKon:  0.0000330M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against the enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50511166(CHEMBL4513436)
Affinity DataKd:  43nMAssay Description:Binding affinity to bovine beta-trypsin in phosphate/HEPES/Tricine/Tris buffer by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50511169(CHEMBL4551377)
Affinity DataKd:  68nMAssay Description:Binding affinity to bovine beta-trypsin in phosphate/HEPES/Tricine/Tris buffer by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50511168(CHEMBL4465587)
Affinity DataKd:  757nMAssay Description:Displacement of (S)-1-((R)-2-amino-3-phenylpropanoyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide from bovine beta-trypsin in phosphate/HEPES/...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50511167(CHEMBL4563187)
Affinity DataKd:  38nMAssay Description:Binding affinity to bovine beta-trypsin in phosphate/HEPES/Tricine/Tris buffer by ITC methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 0.00800nMAssay Description:Concentration required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 0.0450nMAssay Description:Concentration required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50290996(3-tert-Butoxycarbonylamino-4-[2-(4-guanidino-1-phe...)
Affinity DataIC50: 0.760nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50291175(((R)-1-Benzyl-2-{(S)-2-[(R)-4-guanidino-1-(thiazol...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50291167(1-((S)-Oxo-3-(R)-2-amino-1-phenyl-propyl)-pyrrolid...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM14140((2S)-1-[(2S)-2-amino-3-phenylpropanoyl]-N-[1-(1,3-...)
Affinity DataIC50: 5.80nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029499(tert-butyloxy carbonyl-D-Phe-thiazolidine-4-carbox...)
Affinity DataIC50: 8.80nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50291173(1-((S)-2-Amino-3-(R)-phenyl-propionyl)-azetidine-2...)
Affinity DataIC50: 9nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029498(1N-[2-{2-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50: 9.60nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029515(tert-butyloxy carbonyl-D-Phe-azetidine-2-carboxyla...)
Affinity DataIC50: 9.70nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029506(tert-butyloxy carbonyl-D-ethylphenylglycine-Pro-Ar...)
Affinity DataIC50: 9.80nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM29388(Exanta | Melagatran | US11584714, Compound 999)
Affinity DataIC50: 11nMAssay Description:In vitro inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029514((S)-1-((R)-2-Acetylamino-2-phenyl-propionyl)-azeti...)
Affinity DataIC50: 11nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029510(1N-[2-{2-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50: 11nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 13nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029511({(R)-1-Benzyl-2-[(S)-2-((S)-1-formyl-4-guanidino-b...)
Affinity DataIC50: 14nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50129034(CHEMBL207129 | ((R)-2-{(S)-2-[(5-Carbamimidoyl-1H-...)
Affinity DataIC50: 16nMAssay Description:In vitro inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 17nMAssay Description:The compound was evaluated to inhibit trypsin and is expressed in IC50 (The concentration required to inhibit 50% of the enzyme).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50280654((S)-5-Guanidino-2-{[(S)-1-((S)-2-methylamino-2-phe...)
Affinity DataIC50: 20nMAssay Description:In vitro concentration of compound required to inhibit 50% of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50060000((S)-1-((R)-2-Methylamino-2-phenyl-acetyl)-pyrrolid...)
Affinity DataIC50: 20nMAssay Description:In vitro ability to inhibit the activity of TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM65488(MdnA6)
Affinity DataIC50: 21.5nMT: 2°CAssay Description:The inhibition assays were performed in 96-well microtiter plates as follows: 30 uL of the enzyme solution (trypsin [100 ug/mL] or elastase [1.5 U/mL...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029507({(R)-2-[2-((S)-1-Formyl-4-guanidino-butylcarbamoyl...)
Affinity DataIC50: 22nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029500((S)-1-((S)-1,2,3,4-Tetrahydro-isoquinoline-3-carbo...)
Affinity DataIC50: 23nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM65473(MdnA3)
Affinity DataIC50: 28.4nMT: 2°CAssay Description:The inhibition assays were performed in 96-well microtiter plates as follows: 30 uL of the enzyme solution (trypsin [100 ug/mL] or elastase [1.5 U/mL...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM14073((2S)-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimi...)
Affinity DataIC50: 30nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM14075((2S)-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamid...)
Affinity DataIC50: 32nMAssay Description:Thrombin-catalyzed hydrolysis rates were measured spectrophotometrically using human alpha-thrombin, a chromogenic substrate in aqueous buffer, and a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50101132(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Affinity DataIC50: 39nMAssay Description:Compound was evaluated for its inhibitory activity against bovine pancreatic trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029501(5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]...)
Affinity DataIC50: 53nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50120368((2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carb...)
Affinity DataIC50: 72nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50290019((3S,6S,9aS)-6-(3-Methyl-1,2,3,4-tetrahydro-quinoli...)
Affinity DataIC50: 100nMAssay Description:In vitro ability to inhibit the activity of TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50290993(2-(N'-Acetyl-N-benzyl-hydrazinocarbonyl)-cyclohexa...)
Affinity DataIC50: 108nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50144554((R)-1-[4-(Biphenyl-4-carbonyl)-piperazine-1-carbon...)
Affinity DataIC50: 120nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50144558((R)-1-[4-(4-Benzyloxy-benzoyl)-piperazine-1-carbon...)
Affinity DataIC50: 120nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50144553((R)-4-Oxo-1-[4-(4-phenoxy-benzoyl)-piperazine-1-ca...)
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50144580((R)-1-(4-{4-[3-(4-Chloro-phenyl)-[1,2,4]oxadiazol-...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against bovine trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50289433((S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50: 156nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM31459(CHEMBL224485 | substituted biphenyl derivative, 21)
Affinity DataIC50: 170nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029512(tert-butyloxy carbonyl-D-Phe-DL-Pro(5,5-methyl)-Ar...)
Affinity DataIC50: 170nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50029502(1N-[2-[5-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50: 180nMAssay Description:In vitro Enzyme Inhibitory activity measured against TrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50291166((R)-2-((R)-2-Amino-3-phenyl-propionylamino)-N-[(S)...)
Affinity DataIC50: 180nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine protease 1(Bovine)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50101131(1,3-Di-p-tolyl-[1,3]diazetidine-2,4-dione | CHEMBL...)
Affinity DataIC50: 200nMAssay Description:Compound was evaluated for its inhibitory activity against bovine pancreatic trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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