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Report error Found 200 of affinity data for UniProtKB/TrEMBL: O95718
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50336730(4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-meth...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at ZFP-fused ERRbeta LBD expressed in HEK293 cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  4.60nMAssay Description:Agonist activity at ZFP-fused ERRbeta LBD expressed in HEK293 cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50455406(CHEMBL4211789)
Affinity DataEC50:  2.70E+3nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50455420(CHEMBL4217033)
Affinity DataEC50:  31nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50455417(CHEMBL4211016)
Affinity DataEC50:  45nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50455402(CHEMBL4204689)
Affinity DataEC50:  90nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50455427(CHEMBL4206963)
Affinity DataEC50:  20nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50455428(CHEMBL4205664)
Affinity DataEC50:  630nMAssay Description:Agonist activity at alphaHis-SUMO-tagged ERRbeta-LBD (unknown origin) assessed as decrease in RIP140 peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 8.70nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50233271(CHEMBL4071073)
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50427842(CHEMBL2326072)
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50427834(CHEMBL2326068)
Affinity DataIC50: 41nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50233269(CHEMBL4100590)
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50212173(7-bromo-6H-chromeno[4,3-b]quinoline-3,9-diol | CHE...)
Affinity DataIC50: 56nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM485072(US10934303, Example 87 | US10934303, Cmpd No. 27a)
Affinity DataIC50: 70nMAssay Description:ERRα/ERRβ/ERα : In an ERR beta binding assay, GST-bound ERR alpha LBD was used so that a final concentration was 10 nM and a fluoresce...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM544469(87 | US11285226, Compound 27a)
Affinity DataIC50: 70nMAssay Description:In an ERR alpha binding assay, GST-bound ERR alpha LBD was used, and all experiments other than that was the same as the ERR gamma binding assay.In a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50212166(7-chloro-6H-chromeno[4,3-b]quinoline-3,9-diol | CH...)
Affinity DataIC50: 88nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50212172(3,9-dihydroxy-6H-chromeno[4,3-b]quinoline-7-carbon...)
Affinity DataIC50: 98nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50427836(CHEMBL2326070)
Affinity DataIC50: 112nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50427841(CHEMBL2326073)
Affinity DataIC50: 121nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50427835(CHEMBL2326069)
Affinity DataIC50: 151nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50427838(CHEMBL2326076)
Affinity DataIC50: 185nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50233266(CHEMBL4092854)
Affinity DataIC50: 210nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50171724(4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol | 4-bro...)
Affinity DataIC50: 212nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50171726(4-chloro-2-(4-hydroxyphenyl)quinolin-6-ol | 4-Chlo...)
Affinity DataIC50: 213nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50233264(CHEMBL4085105)
Affinity DataIC50: 300nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50427840(CHEMBL2326074)
Affinity DataIC50: 331nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50233267(CHEMBL4084142)
Affinity DataIC50: 350nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM19459(Prunetol | Genisteol | CHEMBL44 | US8552057, 2 | c...)
Affinity DataIC50: 395nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50427839(CHEMBL2326075)
Affinity DataIC50: 436nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50171712(6-Hydroxy-2-(4-hydroxy-phenyl)-quinoline-4-carboni...)
Affinity DataIC50: 455nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50212165(7-(3-chlorophenyl)-6H-chromeno[4,3-b]quinoline-3,9...)
Affinity DataIC50: 504nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50171727(2-(4-Hydroxy-phenyl)-4-vinyl-quinolin-6-ol | 2-(4-...)
Affinity DataIC50: 504nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50212161(7-vinyl-6H-chromeno[4,3-b]quinoline-3,9-diol | CHE...)
Affinity DataIC50: 526nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50212163(7-(4-methoxyphenyl)-6H-chromeno[4,3-b]quinoline-3,...)
Affinity DataIC50: 549nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50233273(CHEMBL4064664)
Affinity DataIC50: 550nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50427837(CHEMBL2326071)
Affinity DataIC50: 566nMAssay Description:Displacement of [3H]E2 from human recombinant ERbeta receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50233265(CHEMBL4065193)
Affinity DataIC50: 600nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50212170(7-ethynyl-6H-chromeno[4,3-b]quinoline-3,9-diol | C...)
Affinity DataIC50: 624nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50171723(4-Ethyl-2-(4-hydroxy-phenyl)-quinolin-6-ol | 4-eth...)
Affinity DataIC50: 634nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50212162(7-ethyl-6H-chromeno[4,3-b]quinoline-3,9-diol | CHE...)
Affinity DataIC50: 641nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM20608([3H]4-OHT | cid_449459 | CHEMBL489 | AFIMOXIFENE |...)
Affinity DataIC50: 650nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50193253(CHEMBL3961676)
Affinity DataIC50: 722nMAssay Description:Inhibition of fluorescien-conjugated coactivator PGC1a binding to ERRbeta (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50233268(CHEMBL4073790)
Affinity DataIC50: 750nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50555949(CHEMBL4795846)
Affinity DataIC50: 774nMAssay Description:Binding affinity to ERRbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50212167(7-(3-methoxyphenyl)-6H-chromeno[4,3-b]quinoline-3,...)
Affinity DataIC50: 820nMAssay Description:Inhibition of human ERbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530064(CHEMBL4437929)
Affinity DataIC50: 861nMAssay Description:Binding affinity to ERRbeta (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50530064(CHEMBL4437929)
Affinity DataIC50: 861nMAssay Description:Binding affinity to ERRbeta (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM485053(US11285226, Compound 18b | US10934303, Cmpd No. 18...)
Affinity DataIC50: 861nMAssay Description:ERRα/ERRβ/ERα : In an ERR beta binding assay, GST-bound ERR alpha LBD was used so that a final concentration was 10 nM and a fluoresce...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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