Compile Data Set for Download or QSAR
Report error Found 1348 of affinity data for UniProtKB/TrEMBL: O76083
LigandPNGBDBM711677(US12187729, Example 28)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711680(US12187729, Example 31)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711694(US12187729, Example 45)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711696(US12187729, Example 47)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711695(US12187729, Example 46)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711678(US12187729, Example 29)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711697(US12187729, Example 48)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711464(US12187729, Example 1)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711670(US12187729, Example 21)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711682(US12187729, Example 33)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711676(US12187729, Example 27)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM50034641(CHEMBL3360415)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PDE9A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM317140(US9617269, Compound WYQ-90-D)
Affinity DataIC50: 0.600nMAssay Description:Inhibition activities of all the N-substituted pyrazolo [3,4-d] pyrimidine ketone compounds according to the present invention to the phosphodiestera...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50034641(CHEMBL3360415)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50034641(CHEMBL3360415)
Affinity DataIC50: 0.600nMAssay Description:Displacement of [3H]-cGMP from PDE9A2 (unknown origin) incubated for 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM711668(US12187729, Example 19)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711681(US12187729, Example 32)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711685(US12187729, Example 36)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM50300099(6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50397844(CHEMBL2179099)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50397850(CHEMBL2179093)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM317136(US9617269, Compound WYQ-87-D | US9617269, Compound...)
Affinity DataIC50: 1nMAssay Description:Inhibition activities of all the N-substituted pyrazolo [3,4-d] pyrimidine ketone compounds according to the present invention to the phosphodiestera...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM711683(US12187729, Example 34)
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711684(US12187729, Example 35)
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711686(US12187729, Example 37)
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711688(US12187729, Example 39)
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM711691(US12187729, Example 42)
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM50034645(CHEMBL3360419)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PDE9A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50034648(CHEMBL3360421)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PDE9A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM131008(US8829000, 70)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:To 150 uL of buffer B (70 mmol/L Tris-HCl, pH7.5, 16.7 mmol/L MgCl2, 33.3 nmol/L [3H]-cGMP) solution containing [3H]-cGMP (specific activity=244.2 GB...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50397845(CHEMBL2177125)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50397848(CHEMBL2179096)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50300113(1-cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50300113(1-cyclopentyl-6-[(3S,4S)-4-methyl-1-(quinoxalin-6-...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50543967(CHEMBL4638644)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50300112(trans-1-cyclopentyl-6-(4-methyl-1-(quinoxalin-6-yl...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50300112(trans-1-cyclopentyl-6-(4-methyl-1-(quinoxalin-6-yl...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM111911(US8623901, 239)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM131013(US8829000, 185)
Affinity DataIC50: 2nMT: 2°CAssay Description:To 150 uL of buffer B (70 mmol/L Tris-HCl, pH7.5, 16.7 mmol/L MgCl2, 33.3 nmol/L [3H]-cGMP) solution containing [3H]-cGMP (specific activity=244.2 GB...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM131014(US8829000, 187)
Affinity DataIC50: 2nMT: 2°CAssay Description:To 150 uL of buffer B (70 mmol/L Tris-HCl, pH7.5, 16.7 mmol/L MgCl2, 33.3 nmol/L [3H]-cGMP) solution containing [3H]-cGMP (specific activity=244.2 GB...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50543966(CHEMBL4642683)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM712667(US12195469, Example 23)
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM50300099(6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50300099(6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50543965(CHEMBL4640285)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50462275(CHEMBL4249954)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant GST-tagged human PDE9A2 expressed in insect cells using cGMP as substrate after 1 hr by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM111910(US8623901, 234)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM131010(US8829000, 85)
Affinity DataIC50: 3nMT: 2°CAssay Description:To 150 uL of buffer B (70 mmol/L Tris-HCl, pH7.5, 16.7 mmol/L MgCl2, 33.3 nmol/L [3H]-cGMP) solution containing [3H]-cGMP (specific activity=244.2 GB...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM131012(US8829000, 180)
Affinity DataIC50: 3nMT: 2°CAssay Description:To 150 uL of buffer B (70 mmol/L Tris-HCl, pH7.5, 16.7 mmol/L MgCl2, 33.3 nmol/L [3H]-cGMP) solution containing [3H]-cGMP (specific activity=244.2 GB...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50034642(CHEMBL3360416)
Affinity DataIC50: 3nMAssay Description:Inhibition of PDE9A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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