Compile Data Set for Download or QSAR
Report error Found 168 for UniProtKB: O60894
LigandPNGBDBM50541411(CHEMBL4643006)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human CLR/RAMP1 by cAMP assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50541409(CHEMBL4647045)
Affinity DataIC50: 0.0450nMAssay Description:Inhibition of human CLR/RAMP1 by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50541412(CHEMBL4644508)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50541404(CHEMBL4639133)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50047356(CHEMBL3334624)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217493(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50541403(CHEMBL4641806)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217485(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217495(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50184071((R)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(2-...)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50184072((R)-4-(2-oxo-1,2,4,5-tetrahydrobenzo[d][1,3]diazep...)
Affinity DataIC50: 43nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50047357(CHEMBL3334623)
Affinity DataIC50: 44nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217488(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217486((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-6-phe...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217486((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-6-phe...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217498((R,Z)-N-(1-isopropyl-2-oxo-5-phenyl-2,3-dihydro-1H...)
Affinity DataIC50: 65nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50184074((R)-N-(3-(3,5-dibromo-4-hydroxyphenyl)-1-oxo-1-(4-...)
Affinity DataIC50: 75nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217483((trans racemic)-N-(1-(cyclopropylmethyl)-2-oxo-5-p...)
Affinity DataIC50: 133nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217483((trans racemic)-N-(1-(cyclopropylmethyl)-2-oxo-5-p...)
Affinity DataIC50: 141nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50541402(CHEMBL4645875)
Affinity DataIC50: 250nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50217490(N-((3R,7R)-1-(cyclopropylmethyl)-2-oxo-7-phenylaze...)
Affinity DataIC50: 408nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217482(tert-butyl 2-((3S,7S)-2-oxo-3-(4-(2-oxo-1,2-dihydr...)
Affinity DataIC50: 471nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217491((trans racemic)-N-((3R)-1-(cyclopropylmethyl)-2-ox...)
Affinity DataIC50: 488nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217491((trans racemic)-N-((3R)-1-(cyclopropylmethyl)-2-ox...)
Affinity DataIC50: 488nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50184068((R)-N-(1-ethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo...)
Affinity DataIC50: 990nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50541401(CHEMBL4634626)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50184075((R)-4-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)-N-(...)
Affinity DataIC50: 1.58E+3nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50184076((R,S)-N-(1-isopropyl-2-oxo-5-phenyl-2,3-dihydro-1H...)
Affinity DataIC50: 1.81E+3nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217482(tert-butyl 2-((3S,7S)-2-oxo-3-(4-(2-oxo-1,2-dihydr...)
Affinity DataIC50: 2.12E+3nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217489((R)-N-(1-(cyclopropylmethyl)-2-oxoazepan-3-yl)-4-(...)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217492(N-(1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Affinity DataIC50: 3.10E+3nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50184070((R)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50: 3.64E+3nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50184067((S)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50: 4.45E+3nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50217496(N-((3S,6R)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 6.63E+3nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50173483((S)-6-Amino-2-[(R)-3-(3,5-dibromo-4-hydroxy-phenyl...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180775([Aib29,Asp31,Pro34,Phe35]CGRP(27-37) | FV-Aib-TDVG...)
Affinity DataKi:  0.00200nMAssay Description:Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50541408(CHEMBL4643140)
Affinity DataKi:  0.00400nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataKi:  0.00500nMAssay Description:Displacement of [125I]CGRP from human cloned CLR/RAMP1 receptor expressed in E10 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180778(FV-Hyp-TDVGPFAF | CHEMBL2371891)
Affinity DataKi:  0.00600nMAssay Description:Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50541406(CHEMBL4649325)
Affinity DataKi:  0.00700nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50385312(CHEMBL2035984)
Affinity DataKi:  0.0140nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM362044(US9833448, Example 4 | US10272077, Example 4)
Affinity DataKi:  0.0150nMAssay Description:Antagonist activity at human CLR/RAMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50385311(CHEMBL2035985)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180781(FV-Tic-TDVGPFAF | CHEMBL2371890)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50062162(FVPTDVGPFAF | CHEMBL264010)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391716(US10300056, Example 1 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0200nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391716(US10300056, Example 1 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0200nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM391716(US10300056, Example 1 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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