Compile Data Set for Download or QSAR
Report error Found 2459 of affinity data for UniProtKB/TrEMBL: O15530
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM6866(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Affinity DataKd:  3.10E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  700nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  190nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  2.60E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  1.70nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  3.50E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataEC50:  1nMAssay Description:Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM92402(PDK1 inhibitor, 2)
Affinity DataEC50:  9nMAssay Description:Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataEC50:  26nMAssay Description:Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM92403(PDK1 inhibitor, 4)
Affinity DataEC50:  200nMAssay Description:Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM92404(CHEMBL250843 | PDK1 inhibitor, 5)
Affinity DataEC50:  9nMAssay Description:Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM92405(PDK1 inhibitor, 6)
Affinity DataEC50:  12nMAssay Description:Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM92406(PDK1 inhibitor, 7)
Affinity DataEC50:  1nMAssay Description:Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target3-phosphoinositide-dependent protein kinase 1 [50-359](Human)
Universitätsklinikum Frankfurt

LigandPNGBDBM199118(Adenosine | (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-...)
Affinity DataKd:  2.00E+4nMpH: 7.4Assay Description:Titrations were performed by a 0.4 µl injection followed by 19 successive injections (2 µl) of each compound(adenosine 500 µM, PS653 250 µM) into a 2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
Target3-phosphoinositide-dependent protein kinase 1 [50-359](Human)
Universitätsklinikum Frankfurt

LigandPNGBDBM50433916(SP-600125 | PS653 ('1,6-dihydrodibenzo[c,d,g]i...)
Affinity DataKd:  1.25E+3nMpH: 7.4Assay Description:Titrations were performed by a 0.4 µl injection followed by 19 successive injections (2 µl) of each compound(adenosine 500 µM, PS653 250 µM) into a 2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223477(US9320734, 316)
Affinity DataKd:  1.74E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223486(US9320734, 331)
Affinity DataKd:  2.60E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223488(US9320734, 332)
Affinity DataKd:  1.70E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223487(US9320734, 333)
Affinity DataKd:  2.20E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223489(US9320734, 360)
Affinity DataKd:  2.40E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223490(US9320734, 335)
Affinity DataKd:  1.45E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223477(US9320734, 316)
Affinity DataKd:  3.13E+4nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223486(US9320734, 331)
Affinity DataKd:  170nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223488(US9320734, 332)
Affinity DataKd:  3.57E+3nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223489(US9320734, 360)
Affinity DataKd:  420nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1 [409-556](Human)
The University of Texas System

US Patent
LigandPNGBDBM223490(US9320734, 335)
Affinity DataKd:  980nMAssay Description:KT1 PH domain small molecule inhibitors were identified using the crystal structure of the AKT1 PH domain bound by PtdIns(1,3,4,5)P4 as descried in T...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  110nMAssay Description:Binding affinity to PDPK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.40nMAssay Description:Binding affinity to PDPK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  190nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  1.70nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.40nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  2.80E+3nMAssay Description:Binding constant for PDPK1 kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  190nMAssay Description:Binding constant for full-length PDPK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  1.70nMAssay Description:Binding constant for full-length PDPK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50078259(CHEMBL3414669)
Affinity DataKd:  1.02E+4nMAssay Description:Binding affinity to GST-tagged PH domain of PDK1 (unknown origin) by surface Plasmon resonance spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50078209(CHEMBL3414686)
Affinity DataKd:  1.95E+4nMAssay Description:Binding affinity to GST-tagged PH domain of PDK1 (unknown origin) by surface Plasmon resonance spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50078207(CHEMBL3414688)
Affinity DataKd:  1.11E+4nMAssay Description:Binding affinity to GST-tagged PH domain of PDK1 (unknown origin) by surface Plasmon resonance spectroscopyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125790(CHEMBL3623846)
Affinity DataEC50:  5.00E+4nMAssay Description:Activation of human PDK1 catalytic activity using PIFtide as substrate after 1 hr by phosphor imager analysis in presence of [gamma-32P]-ATP relative...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125791(CHEMBL3623844)
Affinity DataEC50:  4.00E+4nMAssay Description:Activation of human PDK1 catalytic activity using PIFtide as substrate after 1 hr by phosphor imager analysis in presence of [gamma-32P]-ATP relative...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125792(CHEMBL3623853)
Affinity DataKd: >2.00E+5nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125794(CHEMBL3623852)
Affinity DataKd: >2.00E+5nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125795(CHEMBL3623851)
Affinity DataKd:  1.50E+5nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125797(CHEMBL3623850)
Affinity DataKd:  8.30E+4nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125798(CHEMBL1559959)
Affinity DataKd:  7.50E+4nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125800(CHEMBL3623849)
Affinity DataKd:  1.20E+5nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125804(CHEMBL1568528)
Affinity DataKd:  1.20E+5nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50387244(CHEMBL1549031)
Affinity DataKd: >2.00E+5nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125807(CHEMBL1382642)
Affinity DataKd:  7.40E+4nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125810(CHEMBL3623848)
Affinity DataKd:  1.10E+5nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM50125812(CHEMBL3623847)
Affinity DataKd:  5.00E+4nMAssay Description:Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Displayed 1 to 50 (of 2459 total ) | Next | Last >>
Jump to: