Compile Data Set for Download or QSAR
Report error Found 37 of affinity data for UniProtKB/TrEMBL: O15393
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataEC50:  1.00E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50424712(Camostat Mesilate | Foipan | CAMOSTAT)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of human TMPRSS2-mediated SARS-CoV-2 entry into human Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM513873(bioRxiv20220126.477782, Screening Hit 2)
Affinity DataEC50:  1.25E+4nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In DepthDetails

TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM513874(bioRxiv20220126.477782, Screening Hit 2 | bioRxiv2...)
Affinity DataEC50:  370nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In DepthDetails

TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM533518(jm2c00120, Compound 17)
Affinity DataEC50:  8.40E+4nMAssay Description:Ec50 of SARS-CoV-infected VeroE6 cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM525152(US10988505, Example 2 | N-0385 | Ms-QFR-kbt)
Affinity DataIC50: 1.90nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50032698(CHEMBL3354676 | N-0130)
Affinity DataIC50: 3.10nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM525153(US10988505, Example 3 | N-0386 | Ac-QFR-kbt)
Affinity DataIC50: 3.90nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM525256(N-0438 | (H)Arg-Glu-Phe-Arg-kbt)
Affinity DataIC50: 5.20nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50031706(4-Guanidino-benzoic acid 4-dimethylcarbamoylmethox...)
Affinity DataIC50: 18nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50239965(CHEBI:77032 | Bromhexine)
Affinity DataIC50: 750nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM420291(0591-5329 | 4-(Methoxycarbonyl)phenyl thiophene-2-...)
Affinity DataIC50: 930nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM45440(4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarbox...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of TMPRSS2 (247 to 492 residues) (unknown origin) peptidase domain expressed in Escherichia coli BL21 (DE3) incubated for 30 mins followed...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50022172(CHEMBL275000 | cid_5395514 | (7-Hydroxy-2-oxo-2H-c...)
Affinity DataIC50: 1.37E+3nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM420294(8008-1235 | N-[4-(4-chlorophenyl)-3-ethyl-1,3-thia...)
Affinity DataIC50: 2.64E+3nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM420292(4401-0077 | Antidepressant agent 1)
Affinity DataIC50: 2.68E+3nMAssay Description:To identify inhibitors of TMPRSS2 that may be used directly in clinical studies or as lead compounds to develop targeted drugs, we screened several c...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50613302(CHEMBL5285196)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of TMPRSS2 (106 to 492 residues) (unknown origin) using Boc-QAR-AMC as substrate measured for 20 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50613303(CHEMBL5266850)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of TMPRSS2 (106 to 492 residues) (unknown origin) using Boc-QAR-AMC as substrate measured for 20 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50613298(CHEMBL5270157)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of TMPRSS2 (106 to 492 residues) (unknown origin) using Boc-QAR-AMC as substrate measured for 20 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50613299(CHEMBL5271456)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of TMPRSS2 (106 to 492 residues) (unknown origin) using Boc-QAR-AMC as substrate measured for 20 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50368092(GNF-PF-3839 | PROPAMIDINE CHLORIDE)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of TMPRSS2 (247 to 492 residues) (unknown origin) peptidase domain expressed in Escherichia coli BL21 (DE3) incubated for 30 mins followed...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM525259(N-0385(OH) | Ms-Gln-Phe-Arg-kbt(OH))
Affinity DataIC50: 1.00E+4nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50613305(CHEMBL5287275)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of TMPRSS2 (106 to 492 residues) (unknown origin) using Boc-QAR-AMC as substrate measured for 20 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50613300(CHEMBL5275059)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of TMPRSS2 (106 to 492 residues) (unknown origin) using Boc-QAR-AMC as substrate measured for 20 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50613301(CHEMBL5270536)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of TMPRSS2 (106 to 492 residues) (unknown origin) using Boc-QAR-AMC as substrate measured for 20 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50613304(CHEMBL5275526)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of TMPRSS2 (106 to 492 residues) (unknown origin) using Boc-QAR-AMC as substrate measured for 20 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50122613(3,4-dihydroisoquinoline-2(1H)-carboximidamide | De...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of TMPRSS2 (106 to 492 residues) (unknown origin) using Boc-QAR-AMC as substrate measured for 20 mins by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50122613(3,4-dihydroisoquinoline-2(1H)-carboximidamide | De...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of TMPRSS2 (247 to 492 residues) (unknown origin) peptidase domain expressed in Escherichia coli BL21 (DE3) incubated for 30 mins followed...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50606675(CHEMBL3219079)
Affinity DataKi:  0.900nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50606676(CHEMBL3219087)
Affinity DataKi:  1nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50606674(CHEMBL3219103)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50606673(CHEMBL3219100)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50606672(CHEMBL3219101)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50606671(CHEMBL3219102)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50324475(CHEMBL1229259 | CHEMBL1215083 | Benzylsulfonyl-D-a...)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50349344(CHEMBL1809250)
Affinity DataKi:  53nMAssay Description:Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransmembrane protease serine 2(Human)
University of Bonn

LigandPNGBDBM50349345(CHEMBL1809251)
Affinity DataKi:  68nMAssay Description:Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed