Compile Data Set for Download or QSAR
Report error Found 33 of affinity data for UniProtKB/TrEMBL: O14980
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50617990(CHEMBL5401620)
Affinity DataKd:  5.90E+3nMAssay Description:Binding affinity to CRM1 (unknown origin) assessed as dissociation constant by microscale thermophoresis assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50581761(CHEMBL5093328)
Affinity DataKd:  24nMAssay Description:Binding affinity to Cy3 dye-labelled human CRM1 assessed as dissociation constant in absence of RanGTP at 10 uM incubated for 1 hr by micro-scale the...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50631671(CHEMBL5416145)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to CRM1 (unknown origin) assessed as inhibition of CRM1 binding to IAF-conjugated NES PKI by measuring dissociation constant in the ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50631672(CHEMBL5412563)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to CRM1 (unknown origin) assessed as inhibition of CRM1 binding to IAF-conjugated NES PKI by measuring dissociation constant in the ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50527779(CHEMBL4440028)
Affinity DataKd:  27nMAssay Description:Binding affinity to recombinant His-tagged CRM1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant His-tagged CRM1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50617989(CHEMBL5401589)
Affinity DataKd:  4.60E+3nMAssay Description:Binding affinity to CRM1 (unknown origin) assessed as dissociation constant by microscale thermophoresis assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50631673(CHEMBL5437336)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity to CRM1 (unknown origin) assessed as inhibition of CRM1 binding to IAF-conjugated NES PKI by measuring dissociation constant in the ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50631674(CHEMBL5399606)
Affinity DataKd:  1.20E+4nMAssay Description:Binding affinity to CRM1 (unknown origin) assessed as inhibition of CRM1 binding to IAF-conjugated NES PKI by measuring dissociation constant in the ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataKd:  1.00E+4nMAssay Description:Competitive inhibition of human CRM1 assessed as dissociation constant incubated in presence of RanGTP and IAF-conjugated protein kinase inhibitor pe...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50245464(CHEBI:52646 | LEPTOMYCIN B)
Affinity DataIC50: 1nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50245476(CHEMBL4088268)
Affinity DataIC50: 10nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619732(CHEMBL3898452)
Affinity DataIC50: 16nMAssay Description:Inhibition of XPO1 in human HPBALL cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50245473(CHEMBL4077955)
Affinity DataIC50: 25nMAssay Description:Inhibition of CRM1-mediated nucleocytoplasmic transport in human HeLa cells after 90 mins by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio)
Affinity DataIC50: 34nMAssay Description:Inhibition of XPO1 in human MOLT-16 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50527778(KPT-330 | Selinexor | Xpovio)
Affinity DataIC50: 55nMAssay Description:Inhibition of XPO1 in human HPBALL cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50619732(CHEMBL3898452)
Affinity DataIC50: 112nMAssay Description:Inhibition of XPO1 in human MOLT-16 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50527779(CHEMBL4440028)
Affinity DataIC50: 151nMAssay Description:Inhibition of CRM1 in human HCT-15 cells assessed as reduction in cell viability incubated for 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50245464(CHEBI:52646 | LEPTOMYCIN B)
Affinity DataIC50: 151nMAssay Description:Inhibition of fluorescently labeled PKI phi(0)Leu NES binding to human CRM1 expressed in Escherichia coli BL21 (DE3) by fluorescence polarization com...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50617989(CHEMBL5401589)
Affinity DataIC50: 270nMAssay Description:Inhibition of CRM1 nuclear export in human HeLa cells assessed as CRM1 depletion measured after 6 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50617989(CHEMBL5401589)
Affinity DataIC50: 280nMAssay Description:Inhibition of CRM1-mediated nuclear export in human HeLa cells expressing mCherry-tagged NES reporter incubated for 3 hrs by confocal microscopy anal...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50617991(CHEMBL5437643)
Affinity DataIC50: 340nMAssay Description:Inhibition of CRM1-mediated nuclear export in human HeLa cells expressing mCherry-tagged NES reporter incubated for 3 hrs by confocal microscopy anal...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50617991(CHEMBL5437643)
Affinity DataIC50: 550nMAssay Description:Inhibition of CRM1 nuclear export in human HeLa cells assessed as CRM1 depletion measured after 6 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50527777(CHEMBL4458289)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of nuclear CRM1 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50240512(osthole | 7-Methoxy-8-(3-methyl-but-2-enyl)-chrome...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50540955(CHEMBL1450050)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of fluorescently labeled PKI phi(0)Leu NES binding to human CRM1 expressed in Escherichia coli BL21 (DE3) by fluorescence polarization com...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50320332(8-(3-methylbut-2-enyl)-2H-chromen-2-one | CHEMBL10...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50320333(7-methoxy-8-(3-methylbut-2-enyl)-2H-chromen-2-one ...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303499(7-(methyloxy)-2H-chromen-2-one | 7-Methoxycoumarin...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50540956(CHEMBL4637077)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of fluorescently labeled PKI phi(0)Leu NES binding to human CRM1 expressed in Escherichia coli BL21 (DE3) by fluorescence polarization com...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50540954(CHEMBL4645904)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of fluorescently labeled PKI phi(0)Leu NES binding to human CRM1 expressed in Escherichia coli BL21 (DE3) by fluorescence polarization com...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExportin-1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50317384(ethyl 5-(4-nitrophenyl)-4,6-dioxo-1,4,5,6-tetrahyd...)
Affinity DataIC50: 6.30E+4nMAssay Description:Inhibition of fluorescently labeled PKI phi(0)Leu NES binding to human CRM1 expressed in Escherichia coli BL21 (DE3) by fluorescence polarization com...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed