Compile Data Set for Download or QSAR
Report error Found 49 of affinity data for UniProtKB/TrEMBL: O00754
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataIC50: 10nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataIC50: 50nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50016706(CHEMBL63139 | Octahydro-indolizine-1,2,8-triol | S...)
Affinity DataIC50: 80nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50525018(CHEMBL4465842)
Affinity DataIC50: 440nMAssay Description:Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50: 500nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50: 500nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM688738(US20240190866, Compound ACK903)
Affinity DataIC50: 650nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263091((R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyr...)
Affinity DataIC50: 750nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM688739(US20240190866, Compound ACK904)
Affinity DataIC50: 950nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM688740(US20240190866, Compound ACK905)
Affinity DataIC50: 1.50E+3nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50525017(CHEMBL4462117)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM688737(US20240190866, Compound ACK902)
Affinity DataIC50: 6.80E+3nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263091((R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyr...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM688735(US20240190866, Compound ACK900)
Affinity DataIC50: 1.40E+4nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50525014(CHEMBL4475419)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50525016(CHEMBL4457217)
Affinity DataIC50: 1.93E+4nMAssay Description:Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM688736(US20240190866, Compound ACK901)
Affinity DataIC50: 2.15E+4nMAssay Description:Compounds were diluted to give the final concentration of 100 μM and mixed with 4-MU-α-D-mannopyranoside as substrate and human Golgi α...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50525019(CHEMBL4471561)
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50525020(CHEMBL4518572)
Affinity DataIC50: 3.07E+4nMAssay Description:Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263048((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50163438((2S,3S,4R,5R)-2-Hydroxymethyl-piperidine-3,4,5-tri...)
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibitory concentration against human alpha-mannosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263048((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263091((R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyr...)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263050((R)-2-(((2R,3R,4R)-3,4-dihydroxy-5-oxopyrrolidin-2...)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263047((R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)me...)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263047((R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)me...)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50030374(CHEMBL3344206)
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50525015(CHEMBL4435118)
Affinity DataIC50: 1.16E+5nMAssay Description:Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50030343(CHEMBL3344205)
Affinity DataIC50: 1.43E+5nMAssay Description:Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263050((R)-2-(((2R,3R,4R)-3,4-dihydroxy-5-oxopyrrolidin-2...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50030342(CHEMBL3344204)
Affinity DataIC50: 1.83E+5nMAssay Description:Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263047((R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)me...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50030340(CHEMBL3344203)
Affinity DataIC50: 2.52E+5nMAssay Description:Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263048((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50: 3.50E+5nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50242271(Glyset | N-Hydroxyethyl-1-deoxynojirimycin | CHEMB...)
Affinity DataIC50: 3.79E+5nMAssay Description:Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263050((R)-2-(((2R,3R,4R)-3,4-dihydroxy-5-oxopyrrolidin-2...)
Affinity DataIC50: 7.50E+5nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50030341(CHEMBL3344207)
Affinity DataIC50: 8.73E+5nMAssay Description:Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50030339(CHEMBL3344202)
Affinity DataIC50: 1.83E+6nMAssay Description:Inhibition of alpha-mannosidase (unknown origin) using p-nitrophenyl-alpha-D-mannopyranoside substrate incubated for 10 mins by UV spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataKi:  550nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataKi:  670nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataKi:  2.33E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataKi:  3.25E+4nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataKi:  4.15E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed