Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 4 [K6R,T557I]
Ligand
BDBM166629
Substrate
n/a
Meas. Tech.
In vitro Assay for Inhibition of DPP-4
IC50
>5.0e+4±n/a nM
Citation
 Li, Q; Zhou, M; Han, L; Cao, Q; Wang, X; Zhao, L; Zhou, J; Zhang, H Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors. Chem Biol Drug Des 86:849-56 (2015) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 4 [K6R,T557I]
Synonyms:
DPP4_HUMAN | DPP4 | ADCP2 | CD26 | Dipeptidyl peptidase-IV (DDP-4) | Dipeptidyl peptidase IV (DPP-IV) | Dipeptidyl peptidase-IV (DPP-IV)
Type:
Protein
Mol. Mass.:
88325.11
Organism:
Human
Description:
P27487[K6R,T557I]
Residue:
766
Sequence:
MKTPWRVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADIVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYESVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
  
Inhibitor
Name:
BDBM166629
Synonyms:
Methyl 3-(aminomethyl)-2-(p-tolyl)imidazo[1,2-a]pyridine-6-carboxylate hydrochloride (5n)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COC(=O)c1ccc2nc(c(CN)n2c1)-c1ccc(C)cc1
Structure:
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