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Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50017745
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604668(CHEMBL5180947)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604667(CHEMBL5198028)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604657(CHEMBL5204649)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604649(CHEMBL5202413)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604652(CHEMBL5190674)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604646(CHEMBL5200196)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604662(CHEMBL5173612)
Affinity DataIC50: 5nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604659(CHEMBL5188181)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604661(CHEMBL5206971)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604665(CHEMBL5204001)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604660(CHEMBL5199752)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604651(CHEMBL5186127)
Affinity DataIC50: 11nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604647(CHEMBL5187084)
Affinity DataIC50: 11nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604658(CHEMBL5201084)
Affinity DataIC50: 11nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604653(CHEMBL5182685)
Affinity DataIC50: 12nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604663(CHEMBL5179256)
Affinity DataIC50: 12nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604655(CHEMBL5174806)
Affinity DataIC50: 12nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604666(CHEMBL5205085)
Affinity DataIC50: 13nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604654(CHEMBL5174088)
Affinity DataIC50: 15nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604643(CHEMBL5209880)
Affinity DataIC50: 68nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604656(CHEMBL5169530)
Affinity DataIC50: 128nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604650(CHEMBL5190328)
Affinity DataIC50: 317nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604644(CHEMBL5208030)
Affinity DataIC50: 340nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604648(CHEMBL5197334)
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604664(CHEMBL5193449)
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604645(CHEMBL5173396)
Affinity DataIC50: 8.44E+3nMAssay Description:Inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604668(CHEMBL5180947)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604668(CHEMBL5180947)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition and measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604668(CHEMBL5180947)
Affinity DataKi:  0.400nMAssay Description:Mixed-type inhibition of AChE in mouse cerebral cortex using acetylthiocholine iodide as substrate by double reciprocal Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed