Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50014920
TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581147(CHEMBL5094242)
Affinity DataKd:  73nMAssay Description:Binding affinity to WDR5 (unknown origin) by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50428254(CHEMBL1609857)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to WDR5 (unknown origin) using GSARAEVHLRKS peptide substrate by fluorescence polarization assaysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581147(CHEMBL5094242)
Affinity DataIC50: 780nMAssay Description:Inhibition of MLL1 (unknown origin) histamine methyltransferase activity assessed as inhibition of H3K4 methylation incubated for 30 mins by Alphascr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581147(CHEMBL5094242)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of G9a (unknown origin) assessed as effect on H3K9 methylation incubated for 30 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581147(CHEMBL5094242)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DOT1L (unknown origin) assessed as effect on H3K79 methylation incubated for 30 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581147(CHEMBL5094242)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of EZH2 (unknown origin) assessed as effect on H3K27 methylation incubated for 30 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581147(CHEMBL5094242)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SET8 (unknown origin) assessed as effect on H4K20 methylation incubated for 30 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581147(CHEMBL5094242)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PRMT5 (unknown origin) assessed as effect on H3R8/H4R3 methylation incubated for 30 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed