Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50010632
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540762(CHEMBL4638701)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540762(CHEMBL4638701)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM27497(2-Dimethylamino-N-(6-oxo-5,6-dihydro-phenanthridin...)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540757(CHEMBL4460557)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540759(CHEMBL4648016)
Affinity DataIC50: 12nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM27497(2-Dimethylamino-N-(6-oxo-5,6-dihydro-phenanthridin...)
Affinity DataIC50: 15nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 29nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540759(CHEMBL4648016)
Affinity DataIC50: 37nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540762(CHEMBL4638701)
Affinity DataIC50: 38nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM27497(2-Dimethylamino-N-(6-oxo-5,6-dihydro-phenanthridin...)
Affinity DataIC50: 39nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM27497(2-Dimethylamino-N-(6-oxo-5,6-dihydro-phenanthridin...)
Affinity DataIC50: 53nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540762(CHEMBL4638701)
Affinity DataIC50: 90nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540760(CHEMBL4632484)
Affinity DataIC50: 103nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540757(CHEMBL4460557)
Affinity DataIC50: 193nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540757(CHEMBL4460557)
Affinity DataIC50: 218nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 303nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540761(CHEMBL4641894)
Affinity DataIC50: 318nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540758(CHEMBL4642139)
Affinity DataIC50: 340nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540760(CHEMBL4632484)
Affinity DataIC50: 347nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540761(CHEMBL4641894)
Affinity DataIC50: 356nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540759(CHEMBL4648016)
Affinity DataIC50: 370nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540761(CHEMBL4641894)
Affinity DataIC50: 398nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540757(CHEMBL4460557)
Affinity DataIC50: 549nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540760(CHEMBL4632484)
Affinity DataIC50: 552nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540758(CHEMBL4642139)
Affinity DataIC50: 588nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540758(CHEMBL4642139)
Affinity DataIC50: 673nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540761(CHEMBL4641894)
Affinity DataIC50: 963nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540760(CHEMBL4632484)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540759(CHEMBL4648016)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540758(CHEMBL4642139)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of Naples

Curated by ChEMBL
LigandPNGBDBM50540763(CHEMBL4641161)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed