Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 50010189
TargetSerine palmitoyltransferase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50535847(CHEMBL4541898)
Affinity DataEC50:  4.22E+3nMAssay Description:Inhibition of SPT1 in human MCF7 cells assessed as suppression of 14C-serine incorporation into ceramide incubated for 2 hrs in presence of 4-HPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine palmitoyltransferase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50535848(CHEMBL4584997)
Affinity DataEC50:  977nMAssay Description:Inhibition of SPT1 in human MCF7 cells assessed as suppression of 14C-serine incorporation into ceramide incubated for 2 hrs in presence of 4-HPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine palmitoyltransferase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50461646(CHEBI:582124 | Myriocin)
Affinity DataEC50:  50nMAssay Description:Inhibition of SPT1 in human MCF7 cells assessed as suppression of 14C-serine incorporation into ceramide incubated for 2 hrs in presence of 4-HPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine palmitoyltransferase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50535848(CHEMBL4584997)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human SPT1 expressed in microsomes of HEK293 cells incubated for 1hr by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine palmitoyltransferase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50535847(CHEMBL4541898)
Affinity DataIC50: 64nMAssay Description:Inhibition of human SPT1 expressed in microsomes of HEK293 cells incubated for 1hr by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed