Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50016927
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175387(2-[((2R)-3-{[1,1-Dimethyl-2-(2-naphthalenyl)ethyl]...)
Affinity DataIC50: 30nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50161093(CHEMBL2112075 | CHEMBL180672 | (R)-2-chloro-6-(2-h...)
Affinity DataIC50: 50nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175382((S)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthale...)
Affinity DataIC50: 50nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175375((S)-2-(3-(1-(benzo[b]thiophen-2-yl)-2-methylpropan...)
Affinity DataIC50: 60nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175360((S)-2-(3-(1-(1H-indol-2-yl)-2-methylpropan-2-ylami...)
Affinity DataIC50: 100nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175380((R)-1-((R)-1-(3-nitrobenzyl)pyrrolidin-2-yl)-2-(2-...)
Affinity DataIC50: 140nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175365(2-fluoro-6-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(n...)
Affinity DataIC50: 140nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175384(2-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 140nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175354((R)-1-((R)-1-(2-nitrobenzyl)pyrrolidin-2-yl)-2-(2-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175371(3-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 190nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175377(2-chloro-6-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(n...)
Affinity DataIC50: 240nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175362(4-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 250nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175363(3-(((R)-2-((R)-2-(1-(benzo[b]thiophen-2-yl)-2-meth...)
Affinity DataIC50: 270nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175374((R)-2-chloro-6-(2-hydroxy-3-(methyl(2-methyl-1-(na...)
Affinity DataIC50: 270nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175386(2-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 340nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175378((R)-1-((R)-1-(2,3-difluorobenzyl)pyrrolidin-2-yl)-...)
Affinity DataIC50: 360nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175370(3-(((R)-2-((R)-2-(1-(1H-indol-2-yl)-2-methylpropan...)
Affinity DataIC50: 440nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50161093(CHEMBL2112075 | CHEMBL180672 | (R)-2-chloro-6-(2-h...)
Affinity DataIC50: 530nMAssay Description:Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175357((R)-2-chloro-6-(3-(1-(4-fluorophenyl)-2-methylprop...)
Affinity DataIC50: 600nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175381((R)-1-((R)-1-(3-fluorobenzyl)pyrrolidin-2-yl)-2-(2...)
Affinity DataIC50: 750nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175368((R)-1-((R)-1-(4-nitrobenzyl)pyrrolidin-2-yl)-2-(2-...)
Affinity DataIC50: 790nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175352(2-chloro-6-(3-(2-methyl-1-(naphthalen-2-yl)propan-...)
Affinity DataIC50: 880nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175353(2-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 970nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175358(3-(((R)-2-((R)-2-(1-(benzo[b]thiophen-3-yl)-2-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175355(3-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175372((R)-1-((R)-1-(3-methoxybenzyl)pyrrolidin-2-yl)-2-(...)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175379(2-(((R)-2-((S)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175361(3-(((R)-2-((R)-2-(1-(benzo[d]thiazol-2-yl)-2-methy...)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175388((S)-1-(3-methoxyphenoxy)-3-(1-(4-methoxyphenyl)-2-...)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175359(2-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175376((R)-1-((R)-1-(3-bromobenzyl)pyrrolidin-2-yl)-2-(2-...)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175371(3-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175391((R)-1-((R)-1-Biphenyl-3-ylmethyl-pyrrolidin-2-yl)-...)
Affinity DataIC50: 2.47E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175365(2-fluoro-6-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(n...)
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175364(3-(((R)-2-((R)-1-hydroxy-2-(1-(4-methoxyphenyl)-2-...)
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175390(3-(((R)-2-((R)-2-(1-(1H-benzo[d]imidazol-2-yl)-2-m...)
Affinity DataIC50: 2.84E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175383((R)-1-(1-(4-fluorophenyl)-2-methylpropan-2-ylamino...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175366((R)-2-chloro-6-(2-hydroxy-3-(2-(naphthalen-2-yl)et...)
Affinity DataIC50: 3.86E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175385((R)-2-chloro-6-(2-hydroxy-3-(naphthalen-2-ylamino)...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175367((R)-1-(2,3-dichlorophenylthio)-3-(1-(4-fluoropheny...)
Affinity DataIC50: 6.18E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175373(3-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Affinity DataIC50: 6.84E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175369(3-((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen-...)
Affinity DataIC50: 8.43E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175389((S)-1-(2-methyl-1-phenylpropan-2-ylamino)-3-(2-(me...)
Affinity DataIC50: 9.43E+3nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175356(1-(1-(4-methoxyphenyl)-2-methylpropan-2-ylamino)-3...)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed