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Report error Found 36 of ic50 data for polymerid = 8809
TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM210888(US9290477, 6)
Affinity DataIC50: 1.5nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM210887(US9290477, 5)
Affinity DataIC50: 1.5nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150700(US8981112, 7 | US9526727, 7 | US9949975, Example 7)
Affinity DataIC50: 2nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150705(US8981112, 12 | US9526727, 12 | US9949975, Example...)
Affinity DataIC50: 3nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM210884(US9290477, 2)
Affinity DataIC50: 3.5nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM210883(US9290477, 1)
Affinity DataIC50: 4nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150704(US8981112, 11 | US9526727, 11 | US9949975, Example...)
Affinity DataIC50: 4nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150717(US8981112, 24 | US9526727, 24 | US9949975, Example...)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150697(US8981112, 4 | US9526727, 4)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150714(US8981112, 21 | US9526727, 21 | US9949975, Example...)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150701(US8981112, 8 | US9526727, 8 | US9949975, Example 8)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150707(US8981112, 14 | US9526727, 14 | US9949975, Example...)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150720(US8981112, 27 | US9526727, 27 | US9949975, Example...)
Affinity DataIC50: 6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150712(US8981112, 19 | US9526727, 19 | US9949975, Example...)
Affinity DataIC50: 6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150695(US8981112, 2 | US9526727, 2 | US9949975, Example 2)
Affinity DataIC50: 8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150715(US8981112, 22 | US9526727, 22 | US9949975, Example...)
Affinity DataIC50: 8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM259489(US9526727, 5)
Affinity DataIC50: 8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM210889(US9290477, 7)
Affinity DataIC50: 8.20nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150706(US8981112, 13 | US9526727, 13 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150702(US8981112, 9 | US9526727, 9 | US9949975, Example 9)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150719(US8981112, 26 | US9526727, 26 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150703(US8981112, 10 | US9526727, 10 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150711(US8981112, 18 | US9526727, 18 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150696(US8981112, 3 | US9526727, 3 | US9949975, Example 3)
Affinity DataIC50: 10nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150699(US8981112, 6 | US9526727, 6 | US9949975, Example 6)
Affinity DataIC50: 11nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150709(US8981112, 16 | US9526727, 16 | US9949975, Example...)
Affinity DataIC50: 11nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM259488(US9526727, 1 | US9949975, Example 1)
Affinity DataIC50: 11nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150708(US8981112, 15 | US9526727, 15 | US9949975, Example...)
Affinity DataIC50: 11nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150716(US8981112, 23 | US9526727, 23 | US9949975, Example...)
Affinity DataIC50: 12nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM150710(US8981112, 17 | US9526727, 17 | US9949975, Example...)
Affinity DataIC50: 14nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM210886(US9290477, 4)
Affinity DataIC50: 16.3nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM259485(US9526727, Comparison Example Table 2, 2''-amino-4...)
Affinity DataIC50: 35nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM210885(US9290477, 3)
Affinity DataIC50: 37nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM259486(US9526727, Comparison Example Table 2, (1r,4r)-2''...)
Affinity DataIC50: 49nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195494(US9212153, 158,Ex. 121 | US9526727, Comparison Exa...)
Affinity DataIC50: 107nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM259487(US9526727, Comparison Example Table 2, (1r,1'R,4R)...)
Affinity DataIC50: 415nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent