Compile Data Set for Download or QSAR
Report error Found 52 of ic50 data for polymerid = 8284,49000764,50002505
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)
Affinity DataIC50: 5.10nMAssay Description:Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataIC50: 5.70nMAssay Description:Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 170nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072169((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 340nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072170((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 380nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072177((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 490nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072173((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 750nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072176((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 990nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072171((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 1.23E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataIC50: 1.90E+3nMAssay Description:Antagonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as inhibition of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072168((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 2.25E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072172((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 2.52E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50372868(CHEMBL404886)
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of [3H]-L-AP4 from rat mGluR8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072174((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 5.18E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50523865(CHEMBL4476495)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of mGlu8 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGluR8 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50280374(CHEMBL4174742)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as decrease in glutamate-induced thallium...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50531687(CHEMBL4445682)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of mGlu8 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50280368(CHEMBL4176971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat mGlu8 expressed in HEK cells co-expressing Galpha15 assessed as reduction in L-AP4-induced intracellular calcium flux pret...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50301804(5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human mGluR8 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50301520(4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR8 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50278930(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu8 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50278924(N-methyl-5-(phenylethynyl)pyrimidin-2-amine | CHEM...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGlu8 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50121643(CHEMBL3616847)
Affinity DataIC50: 1.25E+4nMAssay Description:Antagonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataIC50: 1.25E+4nMAssay Description:Antagonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as inhibition of gl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataIC50: 2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu8 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as incr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50: 2.67E+4nMAssay Description:Binding affinity to mGluR8 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50526873(CHEMBL4461592)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mGluR8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of mGlu8R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu8 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50503456(CHEMBL4435396)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu8 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50547329(CHEMBL1527295)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of mGlu8 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50553603(CHEMBL1349403)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of mGlu8 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu8 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50339075(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mGluR8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50346073(cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mGluR8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50116512(CHEMBL3609741)
Affinity DataIC50: 3.00E+4nMAssay Description:Activity at mGlu8 receptor (unknown origin) expressed in HEK293 cells pre-treated for 15 mins before addition of EC80 concentration of reference agon...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50280371(CHEMBL4160779)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at rat mGlu8 expressed in HEK cells co-expressing Galpha15 assessed as reduction in L-AP4-induced intracellular calcium flux pret...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071151((2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071165((2R,4R)-4-Amino-1-(2-chloro-benzyl)-pyrrolidine-2,...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071150((2R,4R)-4-Amino-1-biphenyl-2-ylmethyl-pyrrolidine-...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071164((2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxy...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50049748(2-Amino-4-(4,4-diphenyl-butyl)-pentanedioic acid |...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071167((2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidin...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50049748(2-Amino-4-(4,4-diphenyl-butyl)-pentanedioic acid |...)
Affinity DataIC50: 3.00E+5nMAssay Description:Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 8 by measuring L-AP4 (0.3 uM of forskolin) (...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071168((2R,4R)-4-Amino-1-(3-chloro-benzyl)-pyrrolidine-2,...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071159((2R,4R)-4-Amino-1-naphthalen-1-ylmethyl-pyrrolidin...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071161(4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071155((2R,4R)-4-Amino-1-naphthalen-2-ylmethyl-pyrrolidin...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071156((2R,4R)-4-Amino-1-ethyl-pyrrolidine-2,4-dicarboxyl...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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