Compile Data Set for Download or QSAR
Report error Found 1548 of ic50 data for polymerid = 8047
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264020(2-[5-[(4- cyanophenyl)methoxy]pyrazol-1- yl]pyridi...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM263974(2-(5-(benzyloxy)-1H-pyrazol-1- yl)isonicotinic aci...)
Affinity DataIC50: 1nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264012(2-[5-[(4-chloro-2- methoxyphenyl)methoxy]pyrazol- ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264025(2-(4-[2-(dimethylamino)ethyl]- 5-[(4- fluorophenyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50532176(CHEMBL4542928 | US20240139197, Compound 13)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human N-terminal FLAG/His-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K4(Me3)-GGK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(US9714230, 89 | 2-(5-((4-chloro-2-methylbenzyl)oxy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM263992(2-{5-[(4-bromobenzyl)oxy]-1H- pyrazol-1-yl}pyridin...)
Affinity DataIC50: 2nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(US9714230, 89 | 2-(5-((4-chloro-2-methylbenzyl)oxy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length human KDM5B expressed in baculovirus expression system using (ARTK(me3)QTARKSTGGKAPRKQLA peptide substMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM191600(US9714230, 89 | 2-(5-((4-chloro-2-methylbenzyl)oxy...)
Affinity DataIC50: 2nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 3nMpH: 7.0Assay Description:Time-resolved fluorescence resonance energy transfer (TR-FRET) assays were carried out using full-length KDM5 enzymes in 384-well black ProxiPlates (...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM263991(2-{5-[(4-ethylbenzyl)oxy]- 1H-pyrazol-1-yl}pyridin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 3nMAssay Description:Inhibition of KDM5B (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 3nMAssay Description:Inhibition of KDM5B (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human KDM5B expressed in baculovirus expression system using (ARTK(me3)QTARKSTGGKAPRKQLA peptide substMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 3nMAssay Description:Inhibition of KDM5B (unknown origin ) by HTMS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 3nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264012(2-[5-[(4-chloro-2- methoxyphenyl)methoxy]pyrazol- ...)
Affinity DataIC50: 3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM191598(KDOAM-20 | KDM5-C49 | 2-(((2-((2-(dimethylamino)et...)
Affinity DataIC50: 4nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM263975(2-{5-[(4-fluorobenzyl)oxy]-1H- pyrazol-1-yl}pyridi...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264021(2-[5-[(4-chloro-2- phenylmethoxyphenyl)methoxy] py...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM263978(2-{5-[(4-methoxybenzyl)oxy]-1H- pyrazol-1-yl}pyrid...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50158703(US9714230, 53 | CHEMBL3785832 | US9604961, Example...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM263990(2-{5-[(4-methylbenzyl)oxy]-1H- pyrazol-1-yl}pyridi...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264001(2-{5-[(4-chloro-2- fluorobenzyl)oxy]-1H-pyrazol-1-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM191598(KDOAM-20 | KDM5-C49 | 2-(((2-((2-(dimethylamino)et...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM191598(KDOAM-20 | KDM5-C49 | 2-(((2-((2-(dimethylamino)et...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50481823(CHEMBL5285949)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM670388(US20240139197, Compound 21)
Affinity DataIC50: 4nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264001(2-{5-[(4-chloro-2- fluorobenzyl)oxy]-1H-pyrazol-1-...)
Affinity DataIC50: 4nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 4nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM670395(US20240139197, Compound 37)
Affinity DataIC50: 4nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of KDM5B (unknown origin ) by HTMS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50513343(CHEMBL4449500)
Affinity DataIC50: 5nMAssay Description:Inhibition of full length human KDM5B assessed as decrease in demethylation of substrate using peptide ARTK(me3)QTARKSTGGKAPRKQLA-GGK-biotin as subst...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492438(US10975084, Example 11-145 | 5-(1-tert-butyl-1H- p...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492449(US10975084, Example 11-12 | 6-(1-methylethyl)-5-[1...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492450(US10975084, Example 11-13 | 5-{1-[(1- fluorocyclop...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492451(US10975084, Example 11-14 | 5-[1- (cyclopropylmeth...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492457(US10975084, Example 11-20 | 6-(1-methylethyl)-5-[1...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492458(US10975084, Example 11-21 | 6-(1-methylethyl)-5-(1...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492544(US10975084, Example 11-107 | 5-[1-(2-hydroxy-1,1- ...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492545(US10975084, Example 11-108 | 6-(1-methylethyl)-5-[...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492546(US10975084, Example 11-109 | 5-(1-cyclobutyl-1H- p...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492571(US10975084, Example 11-134 | 5-(1-tert-butyl-1H-py...)
Affinity DataIC50: 5.08nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492439(US10975084, Example 11-146 | 5-[1-(3-methylbutyl)-...)
Affinity DataIC50: 5.22nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492529(US10975084, Example 11-92 | 5-[1-(2-methoxy-1,1- d...)
Affinity DataIC50: 5.29nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM492453(US10975084, Example 11-16 | 5-[1-(2-methoxyethyl)-...)
Affinity DataIC50: 5.73nMAssay Description:In this assay, the potency (IC50) of each compound was determined from a ten point (1:3 serial dilution; final compound concentration range in assay ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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