Compile Data Set for Download or QSAR
Report error Found 33 of ic50 data for polymerid = 774
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525229(WO2022043374, Example 71 | N-[(1S)-1-(1-bicyclo[1....)
Affinity DataIC50: 16nMAssay Description:For the MERS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant MERS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022043374

TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM448319(GC376 | GC-376)
Affinity DataIC50: 28nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525176(WO2022043374, Example 28 | N-[(1S)-1-[[(3-amino-3-...)
Affinity DataIC50: 50nMAssay Description:For the MERS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant MERS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022043374

TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525228(WO2022043374, Example 70 | N-[(1S)-2-[2-[(2R)-2-ch...)
Affinity DataIC50: 54nMAssay Description:For the MERS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant MERS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022043374

TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525203(WO2022043374, Example 51-A | N-[(1S)-1-[[(2-Chloro...)
Affinity DataIC50: 60nMAssay Description:For the MERS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant MERS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022043374

TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419129(3CLpro inhibitor 6h)
Affinity DataIC50: 70nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419130(3CLpro inhibitor 7h)
Affinity DataIC50: 80nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419131(3CLpro inhibitor 6j | 3CLpro inhibitor 7j)
Affinity DataIC50: 80nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525251(WO2022043374, Example 100 | N-[(1S)-2-[2-[(2R)-2-c...)
Affinity DataIC50: 94nMAssay Description:For the MERS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant MERS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022043374

TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419126(3CLpro inhibitor 7c)
Affinity DataIC50: 100nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419131(3CLpro inhibitor 6j | 3CLpro inhibitor 7j)
Affinity DataIC50: 100nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 110nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM484195(UAWJ9-36-3)
Affinity DataIC50: 110nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419128(3CLpro inhibitor 7e)
Affinity DataIC50: 130nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM430624(NHC | EIDD-1931 | N4-Hydroxycytidine | Uridine, 4-...)
Affinity DataIC50: 150nMAssay Description:At 48 hours prior to infection, Calu-3 2B4 cells were plated in a 96-well black-walled clear bottom plate at 5x104 cells/well. A 10 mM stock of NHC w...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419123(3CLpro inhibitor 7a)
Affinity DataIC50: 150nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419127(3CLpro inhibitor 6e)
Affinity DataIC50: 150nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419124(3CLpro inhibitor 6c)
Affinity DataIC50: 150nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525230(WO2022043374, Example 72)
Affinity DataIC50: 170nMAssay Description:For the MERS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant MERS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022043374

TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525253(WO2022043374, Example 73)
Affinity DataIC50: 220nMAssay Description:For the MERS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant MERS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022043374

TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525250(WO2022043374, Example 99 | N-[(1S)-1-(1-bicyclo[1....)
Affinity DataIC50: 230nMAssay Description:For the MERS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant MERS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022043374

TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525252(WO2022043374, Example 101 | N-[(1S)-1-[[[(2R)-2-ch...)
Affinity DataIC50: 320nMAssay Description:For the MERS-CoV 3CLpro assay, 2 μL of 0.02 μM recombinant MERS-CoV 3CL protease were mixed with serial dilutions of each compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022043374

TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419121(3CLpro inhibitor 6a)
Affinity DataIC50: 350nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM429387(med.21724, Compound 58)
Affinity DataIC50: 400nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM419133(GC376 | BDBM429386)
Affinity DataIC50: 410nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420295(med.21724, Compound 67 | alpha-ketoamide inhibitor...)
Affinity DataIC50: 580nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM429388(med.21724, Compound 59)
Affinity DataIC50: 700nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM429372(med.21724, Compound 43 | MPI2)
Affinity DataIC50: 1.70E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM429371(med.21724, Compound 42)
Affinity DataIC50: 2.40E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM429445(med.21724, Compound 118)
Affinity DataIC50: 5.80E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM429442(med.21724, Compound 115)
Affinity DataIC50: 7.30E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM429444(med.21724, Compound 117)
Affinity DataIC50: 7.70E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetOrf1a protein(MERS-CoV)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM429443(med.21724, Compound 116)
Affinity DataIC50: 3.03E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed