Compile Data Set for Download or QSAR
Report error Found 754 of ic50 data for polymerid = 7517,50003601,50007593
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278725(CHEMBL4172769)
Affinity DataIC50: 0.316nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278758(CHEMBL4167445)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278799(CHEMBL4162364)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278793(CHEMBL4160218)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50198429((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Dog)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at dog CCR4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.89nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380884(CHEMBL2018954)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278727(CHEMBL4173046)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278794(CHEMBL4175323)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278797(CHEMBL4160846)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278798(CHEMBL4172635)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380881(CHEMBL2018953)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50545768(CHEMBL4641127)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50490515(CHEMBL2326611)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50490519(CHEMBL2326625)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50490519(CHEMBL2326625)
Affinity DataIC50: 6.30nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50198429((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM236789(US9388149, 20 | US9580412, Example 20)
Affinity DataIC50: 7.20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278787(CHEMBL4173861)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278801(CHEMBL4165356)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500893(CHEMBL3797662)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50175665((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500894(CHEMBL3799578)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500901(CHEMBL3799266)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50545779(CHEMBL4642563)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM236788(US9388149, 19 | US9580412, Example 19)
Affinity DataIC50: 8.10nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50545782(CHEMBL4637695)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM236791(US9388149, 22 | US9580412, Example 22)
Affinity DataIC50: 9.40nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50175665((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...)
Affinity DataIC50: 10nMAssay Description:Calcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278785(CHEMBL4170431)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278724(CHEMBL4169247)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380879(CHEMBL2018968)
Affinity DataIC50: 12.6nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50244050(N-Cycloheptyl-2-[4-(cyclopentylamino)piperidine-1-...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50244126(N-cycloheptyl-7-methoxy-2-(4-(pyrrolidin-1-yl)pipe...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278723(CHEMBL4162097)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278786(CHEMBL4165939)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50278800(CHEMBL4175972)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50490524(CHEMBL2326630)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50490500(CHEMBL2321924)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183119(4-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50: 14nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50380880(CHEMBL2018969)
Affinity DataIC50: 14.8nMAssay Description:Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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