Compile Data Set for Download or QSAR
Report error Found 489 of ic50 data for polymerid = 7505
LigandPNGBDBM552703((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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WIPO WO2022103411

LigandPNGBDBM552704((2S,4R)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropy...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552705((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l ,2,3-triazol-...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552708((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552729(WO2022103411, Compound 52 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 10nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552702((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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WIPO WO2022103411

LigandPNGBDBM552706((2S,4R)-N-(l-(2-chloro-4-(4-methylthia7,ol-5-yl)ph...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552711((2S,4R)-l-((S)-3,3-dimethyl-2-(4-(l-methylcyclopro...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552726(WO2022103411, Compound 47 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552731(WO2022103411, Compound 54 | (2S, 4R)-N-((S)-l-(2'-...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM454848(US10730870, Example 11 | US11512083, Example 11)
Affinity DataIC50: 16.3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM552687((2S,4R)-l-((S)-2-(4-benzyl-lH-l,2,3-triazol-l-yl)-...)
Affinity DataIC50: 20nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552707((2S,4R)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropy...)
Affinity DataIC50: 20nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552709((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 20nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552687((2S,4R)-l-((S)-2-(4-benzyl-lH-l,2,3-triazol-l-yl)-...)
Affinity DataIC50: 20nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552712(WO2022103411, Compound 30 | WO2022103411, Example ...)
Affinity DataIC50: 20nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM50615679(CHEMBL4449823)
Affinity DataIC50: 27nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 60 mins by FP based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50615681(CHEMBL5277721)
Affinity DataIC50: 29nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 60 mins by FP based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM552728(WO2022103411, Compound 49 | (2S, 4R)-l-((S)-2-(4-c...)
Affinity DataIC50: 30nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552710((2S,4R)-l-((S)-3,3-dimethyl-2-(4-(l-(trifluorometh...)
Affinity DataIC50: 40nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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WIPO WO2022103411

LigandPNGBDBM536252(BDBM536273 | (2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-...)
Affinity DataIC50: 67.8nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM454972(US10730870, Example 141 | US11512083, Example 141)
Affinity DataIC50: 70.9nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50615683(CHEMBL5274336)
Affinity DataIC50: 78nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 60 mins by FP based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM552685((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50: 80nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552725(WO2022103411, Compound 46 | (2S, 4R)-l-((S)-2-(4-c...)
Affinity DataIC50: 80nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataIC50: 88nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM454969(US10730870, Example 138 | US10730870, Example 145 ...)
Affinity DataIC50: 100nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM552691((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50: 100nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552683((2S,4R)-N-((R)-3-([1,1'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50: 110nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552692((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50: 110nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552724(WO2022103411, Compound 43 | (2S,4R)-N-((R)-3-([l,l...)
Affinity DataIC50: 110nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552693((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50: 120nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM50628964(CHEMBL5425778)
Affinity DataIC50: 120nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in permeabilized HEK293 cells using NanoGlo substrate incubated for 30 mins by tracer ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50628961(CHEMBL5421220)
Affinity DataIC50: 122nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in permeabilized HEK293 cells using NanoGlo substrate incubated for 30 mins by tracer ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM552690((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50: 130nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM50615678(CHEMBL5285978)
Affinity DataIC50: 130nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 60 mins by FP based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM552684((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50: 150nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552684((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50: 150nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552696(WO2022103411, Example S11)
Affinity DataIC50: 150nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM50615684(CHEMBL4565531)
Affinity DataIC50: 164nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 60 mins by FP based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50628961(CHEMBL5421220)
Affinity DataIC50: 164nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo substrate incubated for 30 mins by tracer based NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM454909(US10730870, Example 76 | US11512083, Example 76)
Affinity DataIC50: 169nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM454884(US10730870, Example 47 | US11512083, Example 47)
Affinity DataIC50: 178nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50615682(CHEMBL5269644)
Affinity DataIC50: 179nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 60 mins by FP based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM171824(US9085572, 34)
Affinity DataIC50: 180nMpH: 7.5Assay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50099062(CHEMBL3344081 | US10730870, Example 3 | US11512083...)
Affinity DataIC50: 185nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM552689((2S,4R)-N-((R)-3-([l,l'-biphenyl]-4-yl)-l-amino-l-...)
Affinity DataIC50: 190nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

LigandPNGBDBM552723(WO2022103411, Compound 42 | (2S,4R)-N-((R)-3-([l,l...)
Affinity DataIC50: 190nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
WIPO WO2022103411

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